Canthaxanthin (Synonyms: E 161g; all-trans-Canthaxanthin)

Name: Canthaxanthin
Brand: MedChemExpress
SKU: HY-B1960
Rating: 4.5 (2 reviews)

Cat. No.: HY-B1960 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

For research use only. We do not sell to patients.

Canthaxanthin Chemical Structure

CAS No. : 514-78-3

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1 mg	USD 57	In-stock	Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE Canthaxanthin

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Description

Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. In addition to its free radical scavenging and antioxidant properties (e.g., the induction of catalase and superoxide dismutase), canthaxanthin shows immunomodulatory activity (e.g. enhancing the proliferation and function of immune competent cells) and plays important role in gap junction communication (e.g. induction of the transmembrane protein connexin)^[1]. At concentrations of 0.1 to 1 x 1000 μM, canthaxanthin significantly reduces the overall number of tumor cells. The greatest inhibition is observed at a canthaxanthin concentration of 1000 after 72 h and 96 h of incubation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Canthaxanthin alters the protective ability of tissues against oxidative stress. Canthaxanthin treatment for 15 d at the dose of 14 μg/kg body weight results in hepatic incorporation of the carotenoid, which is maximum in liver and reaches 0.52 ± 0.05 nmol/g liver. Glutathione peroxidase activity is 35% lower and catalase (59%) and manganese superoxide dismutase (28%) activities are higher in canthaxanthin-treated mice than in controls^[3]. Canthaxanthin? inhibit the growth of mammary tumors in mice and the anti-tumor activity is also influenced by the supplemental dose^[4]. Diet supplementation with canthaxanthin for 3 weeks prior to the carcinogen results in a 65% reduction in the number of mammary cancers by a mechanism not involving pro-vitamin A activity^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

564.84

Formula

C₄₀H₅₂O₂

CAS No.

514-78-3

Appearance

Solid

Color

Reddish brown to black

SMILES

CC(/C=C/C(C(C)(CCC1=O)C)=C1C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(CCC2=O)C)=C2C

Structure Classification

Initial Source

Animals

Microorganisms

extremely halophilic bacteria

Shipping

Shipping with dry ice.

Storage

-20°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (269 KB) SDS (393 KB)

COA (240 KB) HNMR (228 KB)

Handling Instructions (2659 KB)

References

[1]. Esatbeyoglu T, et al. Canthaxanthin: From molecule to function. Mol Nutr Food Res. 2017 Jun;61(6). [Content Brief]

[2]. Huang DS, et al. Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells. Cancer Lett. 1992 Aug 31;65(3):209-13. [Content Brief]

[3]. Palozza P, et al. Canthaxanthin supplementation alters antioxidant enzymes and iron concentration in liver of Balb/c mice. J Nutr. 2000 May;130(5):1303-8. [Content Brief]

[4]. Chew BP, et al. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res. 1999 May-Jun;19(3A):1849-53. [Content Brief]

[5]. Grubbs CJ, et al. Effect of canthaxanthin on chemically induced mammary carcinogenesis. Oncology. 1991;48(3):239-45. [Content Brief]

Animal Administration
^[3]

Mice: Female 6-wk-old Balb/c mice are randomly divided into two groups (n = 10/group). The control group receives olive oil alone (vehicle) and the canthaxanthin-treated group receives canthaxanthin at a dose of 14 μg/kg body weight per day. At the end of the treatment, mice are killed by cervical dislocation and liver is excised, frozen in liquid nitrogen and stored at −80°C^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Esatbeyoglu T, et al. Canthaxanthin: From molecule to function. Mol Nutr Food Res. 2017 Jun;61(6). [Content Brief]

[2]. Huang DS, et al. Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells. Cancer Lett. 1992 Aug 31;65(3):209-13. [Content Brief]

[3]. Palozza P, et al. Canthaxanthin supplementation alters antioxidant enzymes and iron concentration in liver of Balb/c mice. J Nutr. 2000 May;130(5):1303-8. [Content Brief]

[4]. Chew BP, et al. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res. 1999 May-Jun;19(3A):1849-53. [Content Brief]

[5]. Grubbs CJ, et al. Effect of canthaxanthin on chemically induced mammary carcinogenesis. Oncology. 1991;48(3):239-45. [Content Brief]

Canthaxanthin Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canthaxanthin514-78-3E 161g all-trans-CanthaxanthinReactive Oxygen SpeciesEndogenous MetaboliteInhibitorinhibitorinhibit

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Canthaxanthin (Synonyms: E 161g; all-trans-Canthaxanthin)

Customer Review

Canthaxanthin Related Antibodies

2 Publications Citing Use of MCE Canthaxanthin

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•Related Screening Libraries:

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Biological Activity

Protocol

Purity & Documentation

References

Customer Review

Canthaxanthin Related Antibodies

Canthaxanthin Related Classifications

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