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  3. Canthaxanthin

Canthaxanthin (Synonyms: E 161g; all-trans-Canthaxanthin)

Cat. No.: HY-B1960 Purity: >95.0%
Handling Instructions

Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

For research use only. We do not sell to patients.

Canthaxanthin Chemical Structure

Canthaxanthin Chemical Structure

CAS No. : 514-78-3

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Based on 2 publication(s) in Google Scholar

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Description

Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

In Vitro

Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. In addition to its free radical scavenging and antioxidant properties (e.g., the induction of catalase and superoxide dismutase), canthaxanthin shows immunomodulatory activity (e.g. enhancing the proliferation and function of immune competent cells) and plays important role in gap junction communication (e.g. induction of the transmembrane protein connexin)[1]. At concentrations of 0.1 to 1 x 1000 μM, canthaxanthin significantly reduces the overall number of tumor cells. The greatest inhibition is observed at a canthaxanthin concentration of 1000 after 72 h and 96 h of incubation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Canthaxanthin alters the protective ability of tissues against oxidative stress. Canthaxanthin treatment for 15 d at the dose of 14 μg/kg body weight results in hepatic incorporation of the carotenoid, which is maximum in liver and reaches 0.52 ± 0.05 nmol/g liver. Glutathione peroxidase activity is 35% lower and catalase (59%) and manganese superoxide dismutase (28%) activities are higher in canthaxanthin-treated mice than in controls[3]. Canthaxanthin inhibit the growth of mammary tumors in mice and the anti-tumor activity is also influenced by the supplemental dose[4]. Diet supplementation with canthaxanthin for 3 weeks prior to the carcinogen results in a 65% reduction in the number of mammary cancers by a mechanism not involving pro-vitamin A activity[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

564.84

Formula

C₄₀H₅₂O₂

CAS No.

514-78-3

SMILES

CC(/C=C/C(C(C)(CCC1=O)C)=C1C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(CCC2=O)C)=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (1.77 mM; ultrasonic and warming and heat to 80°C)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7704 mL 8.8521 mL 17.7041 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[3]

Mice: Female 6-wk-old Balb/c mice are randomly divided into two groups (n = 10/group). The control group receives olive oil alone (vehicle) and the canthaxanthin-treated group receives canthaxanthin at a dose of 14 μg/kg body weight per day. At the end of the treatment, mice are killed by cervical dislocation and liver is excised, frozen in liquid nitrogen and stored at −80°C[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >95.0%

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Keywords:

CanthaxanthinE 161g all-trans-CanthaxanthinReactive Oxygen SpeciesInhibitorinhibitorinhibit

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