OBI-992 drug-linker
Based on 1 Customer Validation
OBI-992 drug-linker is a drug-linker conjugate composed of the TOP I inhibitor Exatecan (HY-13631) and a linker. OBI-992 drug-linker can be used for the synthesis of the ADC OBI-992.
For research use only. We do not sell to patients.
- Purity: 96.64%
- CAS No.: 3039487-10-7
- Formula: C106H162FN9O37
- Molecular Weight:2173.46
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
OBI-992 is a TROP2-targeting ADC consisting of an anti-TROP2 human monoclonal antibody (R4702), a hydrophilic enzyme-cleavable linker (MCCa-PEG24-VA-PAB), and the payload Exatecan[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3039487-10-7
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Appearance Solid
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Molecular Weight 2173.46
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Formula C106H162FN9O37
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Color White to yellow
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SMILES
O=C(C=CC1=O)N1CC2CCC(C(N[C@@H](CCC(N[C@H](C(N[C@H](C(NC3=CC=C(COC(N[C@H]4CCC5=C6C4=C7C(C(N8C7)=CC([C@](CC)(O)C(OC9)=O)=C9C8=O)=NC6=CC(F)=C5C)=O)C=C3)=O)C)=O)C(C)C)=O)C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (46.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4601 mL | 2.3005 mL | 4.6010 mL | 11.5024 mL |
| 5 mM | 0.0920 mL | 0.4601 mL | 0.9202 mL | 2.3005 mL | |
| 10 mM | 0.0460 mL | 0.2300 mL | 0.4601 mL | 1.1502 mL | |
| 15 mM | 0.0307 mL | 0.1534 mL | 0.3067 mL | 0.7668 mL | |
| 20 mM | 0.0230 mL | 0.1150 mL | 0.2300 mL | 0.5751 mL | |
| 25 mM | 0.0184 mL | 0.0920 mL | 0.1840 mL | 0.4601 mL | |
| 30 mM | 0.0153 mL | 0.0767 mL | 0.1534 mL | 0.3834 mL | |
| 40 mM | 0.0115 mL | 0.0575 mL | 0.1150 mL | 0.2876 mL |
OBI-992 drug-linker Related Classifications
HY-168489 Related Classifications
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