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ciprofloxacin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (22) Apoptosis (15) Bacterial (53) Beta-lactamase (1) Biochemical Assay Reagents (2) Dihydrofolate reductase (DHFR) (2) DNA/RNA Synthesis (3) Drug Derivative (1) Drug Intermediate (11) Drug Metabolite (1) Endogenous Metabolite (2) Fungal (3) G-quadruplex (1) Heme Oxygenase (HO) (1) Isotope-Labeled Compounds (7) Mitochondrial Metabolism (10) Necroptosis (1) Nucleoside Antimetabolite/Analog (1) Potassium Channel (1) Reactive Oxygen Species (ROS) (12) Reference Standards (8) Topoisomerase (11) VEGFR (2) β-catenin (1)
By Research Areas:	Cancer (18) Infection (51) Inflammation/Immunology (4)

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Akt (1)

Antibiotic (22)

Apoptosis (15)

Bacterial (53)

Beta-lactamase (1)

Biochemical Assay Reagents (2)

Dihydrofolate reductase (DHFR) (2)

DNA/RNA Synthesis (3)

Drug Derivative (1)

Drug Intermediate (11)

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Endogenous Metabolite (2)

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Necroptosis (1)

Nucleoside Antimetabolite/Analog (1)

Potassium Channel (1)

Reactive Oxygen Species (ROS) (12)

Reference Standards (8)

Topoisomerase (11)

VEGFR (2)

β-catenin (1)

By Research Areas:

Cancer (18)

Infection (51)

Inflammation/Immunology (4)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0356

*Ciprofloxacin* Maximum Cited Publications 53 Publications Verification Bay-09867	Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection Cancer
Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .

HY-B0356B

Ciprofloxacin hydrochloride monohydrate 50+ Cited Publications Bay-09867 hydrochloride monohydrate	Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection Cancer
Ciprofloxacin (Bay-09867) hydrochloride monohydrate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin hydrochloride monohydrate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin hydrochloride monohydrate has anti-proliferative activity and induces apoptosis. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .

HY-B0356A

Ciprofloxacin monohydrochloride 50+ Cited Publications Bay-09867 monohydrochloride	Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection Cancer
Ciprofloxacin (Bay-09867) monohydrochloride is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin monohydrochloride induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin monohydrochloride has anti-proliferative activity and induces apoptosis. Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .

HY-B0356S1

Ciprofloxacin-d8 Bay-09867-d₈	Bacterial Antibiotic	Infection
Ciprofloxacin-d₈ is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-Y1718

Tridecanoic acid 1 Publications Verification N-Tridecanoic acid	Endogenous Metabolite Bacterial	Infection
Tridecanoic acid (N-Tridecanoic acid) is a medium-chain saturated fatty acid and inhibitor with no antibacterial activity against enterohemorrhagic E. coli (EHEC). When used in combination with Ciprofloxacin (HY-B0356) or Ampicillin (HY-B0522), Tridecanoic acid suppresses persister formation in exponentially growing E. coli and EHEC, but exerts no inhibitory effect on persister formation induced by Kanamycin (HY-16566) or in stationary-phase cells. Tridecanoic acid inhibits biofilm formation in EHEC. It can be used in the research of bacterial infections .

HY-P5589

Plantaricin A PlnA	Bacterial Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. Plantaricin A shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells ^[1][2].

HY-B0356S

Ciprofloxacin-d8 hydrochloride Bay-09867-d8 hydrochloride	Bacterial Antibiotic	Infection
Ciprofloxacin-d₈ (hydrochloride) is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-B0356R

Ciprofloxacin (Standard) Bay-09867 (Standard)	Reference Standards Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection Cancer
Ciprofloxacin (Standard) is the analytical standard of Ciprofloxacin. This product is intended for research and analytical applications. Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .

HY-B0356BR

Ciprofloxacin hydrochloride monohydrate (Standard) Bay-09867 hydrochloride monohydrate (Standard)	Reference Standards Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection Cancer
Ciprofloxacin (hydrochloride monohydrate) (Standard) is the analytical standard of Ciprofloxacin (hydrochloride monohydrate). This product is intended for research and analytical applications. Ciprofloxacin (Bay-09867) hydrochloride monohydrate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin hydrochloride monohydrate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin hydrochloride monohydrate has anti-proliferative activity and induces apoptosis. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .

HY-177716

Ciprofloxacin prodrug-1	Beta-lactamase Bacterial	Infection
Ciprofloxacin prodrug-1 (Compound 35) is an activated prodrug of β-lactase. Ciprofloxacin prodrug-1 exhibits good antibacterial activity against bacteria containing β-lactase (MIC = 63 nM). After being hydrolyzed by β-lactase, Ciprofloxacin prodrug-1 can release Ciprofloxacin (HY-B0356), thereby inhibiting the activity of DNA gyrase. Ciprofloxacin prodrug-1 can be used to study infections caused by enzyme-producing drug-resistant bacteria (such as uropathogenic Escherichia coli) .

HY-B0356AS1

Ciprofloxacin-13C3,15N monohydrochloride Bay-09867-13C3,15N monohydrochloride	Antibiotic Topoisomerase Reactive Oxygen Species (ROS) Bacterial Apoptosis Mitochondrial Metabolism Isotope-Labeled Compounds	Infection
Ciprofloxacin- ¹³C₃, ¹⁵N (Bay-09867- ¹³C₃, ¹⁵N) monohydrochloride is ¹³C- and ¹⁵N-labeled Ciprofloxacin (monohydrochloride) (HY-B0356A) .

HY-122139

*Desethylene Ciprofloxacin* hydrochloride**	Bacterial	Infection
Desethylene Ciprofloxacin hydrochloride is a major metabolite of Ciprofloxacin (HY-B0356). Ciprofloxacin is an orally active topoisomerase IV inhibitor. Desethylene Ciprofloxacin hydrochloride has antibacterial activity .

HY-W040298

Ciprofloxacin lactate Bay-09867 lactate	Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection Cancer
Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .

HY-146328

PqsR/LasR-IN-2	Bacterial Antibiotic	Infection
PqsR/LasR-IN-2 (Compound 3) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-2 also inhibits hERG with the IC₅₀ of 1.408 µM .

HY-146329

PqsR/LasR-IN-3	Bacterial Antibiotic	Infection
PqsR/LasR-IN-3 (Compound 7a) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-3 also inhibits hERG with the IC₅₀ of 109.01 µM .

HY-W040298R

Ciprofloxacin lactate (Standard) Bay-09867 lactate (Standard)	Reference Standards Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection Cancer
Ciprofloxacin (lactate) (Standard) is the analytical standard of Ciprofloxacin (lactate). This product is intended for research and analytical applications. Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity [4].

HY-122139R

*Desethylene Ciprofloxacin* hydrochloride (Standard)**	Bacterial Reference Standards	Infection
Desethylene Ciprofloxacin (hydrochloride) (Standard) is the analytical standard of Desethylene Ciprofloxacin (hydrochloride). This product is intended for research and analytical applications. Desethylene Ciprofloxacin hydrochloride is a major metabolite of Ciprofloxacin (HY-B0356). Ciprofloxacin is an orally active topoisomerase IV inhibitor. Desethylene Ciprofloxacin hydrochloride has antibacterial activity .

HY-141789S

*Desethylene Ciprofloxacin-d4 hydrochloride*	Isotope-Labeled Compounds	Others
Desethylene Ciprofloxacin-d₄ (hydrochloride) is the deuterium labeled Desethylene Ciprofloxacin hydrochloride .

HY-B0356AS

Ciprofloxacin-d8 hydrochloride hydrate Bay-09867-d8 hydrochloride hydrate	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Ciprofloxacin-d₈ (hydrochloride hydrate) is the deuterium labeled Ciprofloxacin hydrochloride monohydrate. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-B0356BS

Ciprofloxacin-d8 hydrochloride monohydrate Bay-09867-d8 hydrochloride monohydrate	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Ciprofloxacin-d₈ (hydrochloride monohydrate) is the deuterium labeled Ciprofloxacin (hydrochloride monohydrate). Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-154768S

Ciprofloxacin-piperazinyl-N-sulfate-d8	Isotope-Labeled Compounds	Others
Ciprofloxacin-piperazinyl-N-sulfate-d₈ is deuterated labeled Ciprofloxacin-piperazinyl-N-sulfate.

HY-B0356AR

Ciprofloxacin monohydrochloride (Standard) Bay-09867 monohydrochloride (Standard)	Reference Standards Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection Cancer
Ciprofloxacin (monohydrochloride) (Standard) is the analytical standard of Ciprofloxacin (monohydrochloride). This product is intended for research and analytical applications. Ciprofloxacin (Bay-09867) monohydrochloride is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin monohydrochloride induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin monohydrochloride has anti-proliferative activity and induces apoptosis. Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity [4].

HY-NP0248

Ciprofloxacin-BSA	Biochemical Assay Reagents	Inflammation/Immunology
Ciprofloxacin-BSA is a conjugate of Ciprofloxacin (HY-B0356) and BSA. By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells .

HY-N8606

N-Acetylciprofloxacin	Endogenous Metabolite	Others
N-Acetylciprofloxacin is the metabolite of Ciprofloxacin (HY-B0356) .

HY-B0356S2

Ciprofloxacin-d4 Bay-09867-d₄	Isotope-Labeled Compounds Antibiotic Bacterial Apoptosis Topoisomerase Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Infection Cancer
Ciprofloxacin-d₄ (Bay-09867-d₄) is deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .

HY-W097867

3-Desmethyl Gatifloxacin 8-Methoxy ciprofloxacin; 8-Methoxy-cipro	Bacterial	Infection
3-Desmethyl Gatifloxacin (8-Methoxy Ciprofloxacin) induces DNA cleavage mediated by wild-type gyrase and Quinolone-resistant mutants. 3-Desmethyl Gatifloxacin can be used for research of drug resistance .

HY-147782

Anticancer agent 67	Apoptosis	Cancer
Anticancer agent 67 (Compound 13g) is an anti-cancer agent. Anticancer agent 67 induces apoptosis and increases sub-G1 cell population in MCF-7 cells. Anticancer agent 67 is a ciprofloxacin analog .

HY-147781

Anticancer agent 66	Apoptosis	Cancer
Anticancer agent 66 (Compound 13e) is an anti-cancer agent. Anticancer agent 66 induces apoptosis and increases sub-G1 cell population in MCF-7 cells. Anticancer agent 66 is a ciprofloxacin analog .

HY-161258

Antibacterial agent 181	Bacterial	Infection
Antibacterial agent 181 (Compound 3f) is a potent ciprofloxacin cationic antibacterial agent with low cytotoxicity. The MIC values of Antibacterial agent 181 against Staphylococcus aureus and Escherichia coli are both 2 μg/mL .

HY-151944

Antibacterial agent 128	Bacterial Antibiotic	Infection
Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (HY-B0356) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against *P. aeruginosa* (MIC values of 0.25-64 μg/mL) and *B. pseudomallei* (MIC values of 1-32 μg/mL) .

HY-W753945

N‐Nitrosociprofloxacin	Drug Intermediate	Others
N‐Nitrosociprofloxacin is a Ciprofloxacin (HY-B0356) impurity.

HY-19895

DS-8587	Bacterial	Infection
DS-8587 is a new fluoroquinolone with significant antibacterial activity. The MIC value of DS-8587 against clinically isolated amoxicillin-resistant Bacillus strains is superior to ciprofloxacin and levofloxacin. The antibacterial activity of DS-8587 is less affected by adeA/adeB/adeC or abeM efflux pumps, and has more advantages than ciprofloxacin. DS-8587 has a lower single-step mutation frequency than ciprofloxacin. DS-8587 may be an effective drug for inhibiting amoxicillin-resistant Bacillus infections .

HY-132925

Antifungal agent 16	Fungal	Infection
Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively.

HY-149997

Anticancer agent 120	Bacterial Reactive Oxygen Species (ROS) Apoptosis	Cancer
Anticancer agent 120 (compound 21) is an N-acylated ciprofloxacin derivative, which has certain antibacterial activity and induces ROS to promote cancer cell apoptosis .

HY-154862

Anticancer agent 119	Apoptosis	Infection Cancer
Anticancer agent 119 (compound 15) is an N-acylated ciprofloxacin derivative, which has certain antibacterial activity and induces ROS production to promote cancer cell apoptosis .

HY-120011

Ro 24-6392	Bacterial	Others
Ro 24-6392 is an ester-linked co-drug combining Ciprofloxacin (HY-B0356) and Desacetylcefotaxime (HY-126129) with inhibitory activity against a variety of aerobic bacteria in vitro.

HY-147969

Antiangiogenic agent 2	Nucleoside Antimetabolite/Analog	Cancer
Antiangiogenic agent 2 (compound 3b) is a potent thymidine phosphorylase inhibitor, with an IC₅₀ of 39.71 μM. Antiangiogenic agent 2 shows anti-angiogenic activity .

HY-154861

Anticancer agent 118	Bacterial Apoptosis Necroptosis	Cancer
Anticancer agent 118, a N‑acylated ciprofloxacin derivative, has anti-bacterial and anticancer activities. Anticancer agent 118 shows high activity against Gram-positive strains and antiproliferative activities against prostate PC3 cells. Anticancer agent 118 can be used for antitumor research .

HY-146327

PqsR/LasR-IN-1	Bacterial Antibiotic	Infection
PqsR/LasR-IN-1 (compound 2a) is a potent PqsR and LasR systems inhibitor. PqsR/LasR-IN-1 has anti-virulence activity against Pseudomonas aeruginosa. PqsR/LasR-IN-1 can reduce production of biofilm, pyocyanin, and rhamnolipids in PA .

HY-146329R

PqsR/LasR-IN-3 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Ganoderic acid C2 (Standard) is the analytical standard of Ganoderic acid C2. This product is intended for research and analytical applications. Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (RLAR) with an IC50 of 3.8 µM .

HY-146328R

PqsR/LasR-IN-2 (Standard)	Reference Standards Bacterial Antibiotic	Infection
PqsR/LasR-IN-2 (Standard) is the analytical standard of PqsR/LasR-IN-2. This product is intended for research and analytical applications. PqsR/LasR-IN-2 (Compound 3) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-2 also inhibits hERG with the IC50 of 1.408 µM[1].

HY-146327R

PqsR/LasR-IN-1 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Scopolamine butylbromide (Standard) is the analytical standard of Scopolamine butylbromide. This product is intended for research and analytical applications. 0

HY-149333

BO-1	Bacterial	Infection
BO-1 is a benzoate ester with antibacterial activity. BO-1 inhibits multidrug-resistant Staphylococcus aureus, and acts function synergistically with antibiotic, such as Ciprofloxacin (HY-B0356). BO-1 can reverse the resistance of antibiotic-resistant S. aureus strains, and decreases the level of inflammatory factors IL-6 and C-reactive protein in vivo in mice .

HY-149881

Quorum sensing-IN-2	Bacterial	Infection
Quorum sensing-IN-2 (compound 23e) is a quorum sensing inhibitor, which can reduce the pathogenicity of bacteria without affecting bacterial growth. Quorum sensing-IN-2 inhibits bacterial infections with little hemolytic activity. Quorum sensing-IN-2 shows synergistic effect with Ciprofloxacin (HY-B0356) in the bacteremia model infected with P. aeruginosa PAO1 .

HY-168631

Antibacterial agent 254	Bacterial	Infection
Antibacterial agent 254 (Compound 2) is a dispersion sensor (DspS) activator that disperses Pseudomonas aeruginosa biofilms. Antibacterial agent 254 can dislodge 7-day P. aeruginosa biofilms at 50 μM. Antibacterial agent 254 also enhances the effects of Ciprofloxacin (HY-B0356) against P. aeruginosa and increases the expression of matrix-degrading enzyme genes pelA, pslG and eddA .

HY-123508

PD 131628	Drug Metabolite Bacterial	Infection
PD 131628 is an antimicrobial agent and active PD 131112 metabolite. PD 131628 is two- to four-fold more active than Ciprofloxacin (HY-B0356), inhibiting all strains of Staphylococcus aureus and Streptococcus pneumoniae. PD 131628 is very active against Neisseria spp., Haemophilus influenzae and Moraxella catarrhalis, with MIC₉₀s ranging from 0.004 to 0.008 mg/L .

HY-155479

PqsR-IN-3	Bacterial	Infection
PqsR-IN-3 (compound 16e) is a selective inhibitor of the pqs system (IC₅₀=3.7 μM) and its associated virulence factor pyocyanin (IC₅₀=2.7 μM). PqsR-IN-3 inhibits bacterial biofilm synthesis and is significantly cytotoxic against Pseudomonas aeruginosa. PqsR-IN-3 has synergistic effects with several antibiotics, such as Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441) .

HY-W285163

Ciprofloxacin impurity 9 Formyl ciprofloxacin	Drug Intermediate	Others
Ciprofloxacin impurity 9 (Formyl Ciprofloxacin) is an impurity of Ciprofloxacin.

HY-151458

VEGFR-2/DHFR-IN-1	VEGFR Bacterial Dihydrofolate reductase (DHFR) Fungal	Infection Cancer
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC₅₀s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC₅₀ values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer .

HY-151459

VEGFR-2/DHFR-IN-2	VEGFR Bacterial Dihydrofolate reductase (DHFR) Fungal	Infection Cancer
VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC₅₀s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC₅₀ values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer .

Cat. No.	Product Name	Type

HY-B0356G

Ciprofloxacin

Bay-09867

Fluorescent Dyes

Ciprofloxacin GMP is Ciprofloxacin (HY-B0356) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Ciprofloxacin (Bay-09867) is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin exerts bactericidal effects primarily by inhibiting topoisomerase II and IV. Ciprofloxacin inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity .

Cat. No.	Product Name	Type

HY-NP0248

Ciprofloxacin-BSA	Biochemical Assay Reagents
Ciprofloxacin-BSA is a conjugate of Ciprofloxacin (HY-B0356) and BSA. By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells .

HY-B0356G

Ciprofloxacin

Bay-09867

Biochemical Assay Reagents

HY-NP0248A

Ciprofloxacin-OVA	Biochemical Assay Reagents
Ciprofloxacin-OVA is a conjugate of Ciprofloxacin (HY-B0356) and Ovalbumin (OVA). By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells .

Cat. No.	Product Name	Target	Research Area

HY-P5589

Plantaricin A PlnA	Bacterial Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. Plantaricin A shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells ^[1][2].

HY-P11615

FuK	Bacterial	Infection
FuK is a WK₂-analog antimicrobial peptide modified with fluorinated unnatural amino acids. FuK has an LD₅₀ of 72.34 mg/kg in mice, shows no hemolytic activity, with high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing the permeability of bacterial outer membranes, inducing depolarization of cytoplasmic membranes, and disrupting membrane potential balance against bacterias such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK exhibits synergistic antimicrobial activity with polymyxin B (HY-149179), vancomycin (HY-B0671), and ciprofloxacin (HY-B0356), and also inhibits Ciprofloxacin-induced bacterial drug resistance. FuK has in vivo safety, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y1718

Tridecanoic acid 1 Publications Verification N-Tridecanoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Bacterial
Tridecanoic acid (N-Tridecanoic acid) is a medium-chain saturated fatty acid and inhibitor with no antibacterial activity against enterohemorrhagic E. coli (EHEC). When used in combination with Ciprofloxacin (HY-B0356) or Ampicillin (HY-B0522), Tridecanoic acid suppresses persister formation in exponentially growing E. coli and EHEC, but exerts no inhibitory effect on persister formation induced by Kanamycin (HY-16566) or in stationary-phase cells. Tridecanoic acid inhibits biofilm formation in EHEC. It can be used in the research of bacterial infections .

HY-N8606

N-Acetylciprofloxacin	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
N-Acetylciprofloxacin is the metabolite of Ciprofloxacin (HY-B0356) .

HY-N18102

3,4-Seco-mansumbinoic acid	Structural Classification Commiphora myrrha (Nees) Engl. Ketones, Aldehydes, Acids Plants Burseraceae Source Classification	Bacterial
3,4-Seco-mansumbinoic acid (Compound 2) is an Antibacterial agent. 3,4-Seco-mansumbinoic acid can be isolated from the oleo-resin of Commiphora molmol. 3,4-Seco-mansumbinoic acid exhibits in vitro anti-staphylococcal activity, with the strongest activity against the multidrug-resistant Staphylococcus aureus strain SA-1199B (MIC 4 μg/mL) 3,4-Seco-mansumbinoic acid displays weak potentiation of Ciprofloxacin (HY-B0356) and Tetracycline (HY-A0107) activity against strains of Salmonella enterica serovar Typhimurium SL1344 and L10. 3,4-Seco-mansumbinoic acid can be used for the research of multidrug-resistant bacterial infection (Staphylococcus aureus, Salmonella enterica serovar Typhimurium) .

Cat. No.	Product Name	Chemical Structure

HY-B0356S1

Ciprofloxacin-d8
Ciprofloxacin-d₈ is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-B0356S

Ciprofloxacin-d8 hydrochloride
Ciprofloxacin-d₈ (hydrochloride) is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-B0356AS1

Ciprofloxacin-13C3,15N monohydrochloride
Ciprofloxacin- ¹³C₃, ¹⁵N (Bay-09867- ¹³C₃, ¹⁵N) monohydrochloride is ¹³C- and ¹⁵N-labeled Ciprofloxacin (monohydrochloride) (HY-B0356A) .

HY-141789S

*Desethylene Ciprofloxacin-d4 hydrochloride*
Desethylene Ciprofloxacin-d₄ (hydrochloride) is the deuterium labeled Desethylene Ciprofloxacin hydrochloride .

HY-B0356AS

Ciprofloxacin-d8 hydrochloride hydrate
Ciprofloxacin-d₈ (hydrochloride hydrate) is the deuterium labeled Ciprofloxacin hydrochloride monohydrate. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-B0356BS

Ciprofloxacin-d8 hydrochloride monohydrate
Ciprofloxacin-d₈ (hydrochloride monohydrate) is the deuterium labeled Ciprofloxacin (hydrochloride monohydrate). Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-154768S

Ciprofloxacin-piperazinyl-N-sulfate-d8
Ciprofloxacin-piperazinyl-N-sulfate-d₈ is deuterated labeled Ciprofloxacin-piperazinyl-N-sulfate.

HY-B0356S2

Ciprofloxacin-d4

Ciprofloxacin-d₄ (Bay-09867-d₄) is deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .

HY-W285163S

1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d₈ is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0356G

Ciprofloxacin Bay-09867	Bacterial Topoisomerase Akt β-catenin	Inflammation/Immunology
Ciprofloxacin GMP is Ciprofloxacin (HY-B0356) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Ciprofloxacin (Bay-09867) is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin exerts bactericidal effects primarily by inhibiting topoisomerase II and IV. Ciprofloxacin inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity .

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ciprofloxacin

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