Antibacterial agent 128 

Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (Ciprofloxacin (HY-B0356)) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against P. aeruginosa (MIC values of 0.25-64 μg/mL) and B. pseudomallei (MIC values of 1-32 μg/mL)^[1].

MIC: 0.25-64 μg/mL (P. aeruginosa), 1-32 μg/mL (B. pseudomallei), 4-128 μg/mL (B. thailandensis)^[1]

Antibacterial agent 128 (compound 2d), bearing an hydroxypyridinone moiety with a cleavable linker, active on a large panel of strains of P. aeruginosa (MIC = 0.25-64 μg/mL), B. pseudomallei (MIC = 1-32 μg/mL) and B. thailandensis (MIC = 4-128 μg/mL). Moreover, Antibacterial agent 128 is active on the P. aeruginosa Ciprofloxacin-resistant strain AM85 without cytotoxicity^[1].
Using iron transport systems is a promising strategy to bypass the bacteria cell membrane and restore the activity of conventional antibiotics such as Ciprofloxacin. The siderophore analogs correspond to a mono-catechol or a hydroxypyridinone moiety recognized by both Pseudomonas and Burkholderia species. Physico-chemical studies show that (i) conjugates were unable to interact or cross the membrane by passive diffusion and (ii) conjugates with cleavable linker are stable in physiologic environment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

556.50

C₂₆H₂₅FN₄O₉

CC(OC(N1CCN(CC1)C2=CC3=C(C(C(C(O)=O)=CN3C4CC4)=O)C=C2F)=O)OC(C5=CC(C(O)=CN5)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. P Loupias, et al. Synthesis and study of new siderophore analog-ciprofloxacin conjugates with antibiotic activities against Pseudomonas aeruginosa and Burkholderia spp. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114921.  [Content Brief]