1. Protein Tyrosine Kinase/RTK
    Anti-infection
    Metabolic Enzyme/Protease
  2. VEGFR
    Bacterial
    Dihydrofolate reductase (DHFR)
    Fungal
  3. VEGFR-2/DHFR-IN-2

VEGFR-2/DHFR-IN-2 

Cat. No.: HY-151459
Handling Instructions

VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer.

For research use only. We do not sell to patients.

VEGFR-2/DHFR-IN-2 Chemical Structure

VEGFR-2/DHFR-IN-2 Chemical Structure

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Description

VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer[1].

IC50 & Target

VEGFR2

0.623 μM (IC50)

DHFR

9.085 μM (IC50)

In Vitro

VEGFR-2/DHFR-IN-2 (2-1024 μg/mL; 18-72 h) shows antibacterial and antifungal activities with MIC values of 64, 64, 32, 32, 16, 32, 64 and 256 μg/mL for Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Salmonella enterica, MSSA, MRSA, Candida albicans and Aspergillus niger, respectively[1].
VEGFR-2/DHFR-IN-2 (0.5-100 μM; 48 h) exhibits anticancer activities[1].
VEGFR-2/DHFR-IN-2 (0-100 μM; 30 min) shows DHFR and VEGFR-2 inhibitory activities with IC50s of 9.085 and 0.623 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: C26, HepG2, MCF7 and H69PR cell lines
Concentration: 0.5, 1, 5, 10, 25, 50, 80 and 100 μM
Incubation Time: 48 hours
Result: Showed anticancer activities to C26, HepG2, MCF7 and H69PR cells with IC50s of 3.59, 8.38, 6.75 and 28.45 μM, respectively.
Molecular Weight

351.40

Formula

C21H21NO4

SMILES

O=C(NCC1=CC=C(C)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
VEGFR-2/DHFR-IN-2
Cat. No.:
HY-151459
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