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Cat. No.: HY-151459

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VEGFR-2/DHFR-IN-2

VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC₅₀s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC₅₀ values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2831498-09-8
Formula: C₂₁H₂₁NO₄
Molecular Weight:351.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

VEGFR-2/DHFR-IN-2 Chemical Structure

CAS No.: 2831498-09-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

VEGFR2

0.623 μM (IC₅₀)

DHFR

9.085 μM (IC₅₀)

All VEGFR Isoforms :

In Vitro

VEGFR-2/DHFR-IN-2 (2-1024 μg/mL; 18-72 h) shows antibacterial and antifungal activities with MIC values of 64, 64, 32, 32, 16, 32, 64 and 256 μg/mL for Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Salmonella enterica, MSSA, MRSA, Candida albicans and Aspergillus niger, respectively^[1].
VEGFR-2/DHFR-IN-2 (0.5-100 μM; 48 h) exhibits anticancer activities^[1].
VEGFR-2/DHFR-IN-2 (0-100 μM; 30 min) shows DHFR and VEGFR-2 inhibitory activities with IC₅₀s of 9.085 and 0.623 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

C26, HepG2, MCF7 and H69PR cell lines
Concentration:

0.5, 1, 5, 10, 25, 50, 80 and 100 μM
Incubation Time:

48 hours
Result:

Showed anticancer activities to C26, HepG2, MCF7 and H69PR cells with IC₅₀s of 3.59, 8.38, 6.75 and 28.45 μM, respectively.

Chemical Information

CAS No. 2831498-09-8
Molecular Weight 351.40
Formula C₂₁H₂₁NO₄
SMILES

O=C(NCC1=CC=C(C)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pham EC, et al. Design, Microwave-Assisted Synthesis, Antimicrobial and Anticancer Evaluation, and In Silico Studies of Some 2-Naphthamide Derivatives as DHFR and VEGFR-2 Inhibitors. ACS. 2022.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VEGFR-2/DHFR-IN-2

All VEGFR Isoforms