2831498-09-8
2831498-09-8
Chemical Structure
VEGFR-2/DHFR-IN-2
- CAS No.: 2831498-09-8
- Formula:C21H21NO4
- Molecular Weight:351.40
IUPAC Name: 4-hydroxy-5,7-dimethoxy-N-(4-methylbenzyl)-2-naphthamide
InChIKey: HNROAMNVJXQCMU-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=C(C)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2
Biological Activity: VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer[1].
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VEGFR-2/DHFR-IN-2 | VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer. | |||||||||||||||||||||
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References
Keywords
