Antibacterial agent 345

Antibacterial agent 345 (Compound 9) inhibits Staphylococcus aureus (ATCC 29213) with a MIC of 0.06 μg/mL and inhibits Pseudomonas aeruginosa (PAO1 ATCC 15692) with a MIC of 32 μg/mL^[1].
Antibacterial agent 345 (0.5-32 μg/mL; 24 h) inhibits Staphylococcus aureus (ATCC 29213) biofilm formation by 50% at 0.5 μg/mL and Pseudomonas aeruginosa (PAO1 ATCC 15692) biofilm formation by 50% at 32 μg/mL^[1].
Antibacterial agent 345 (0.06-0.24 μg/mL; 2-24 h) exhibits concentration- and time-dependent bactericidal activity against Staphylococcus aureus (ATCC 29213), achieving a 3 log reduction in CFU at 4×MIC (0.24 μg/mL) after 24 h of incubation^[1].
Antibacterial agent 345 (0.125-0.5 μg/mL; 90 min) inhibits DNA gyrase activity in Escherichia coli DH5α pUC19 in a concentration-dependent manner^[1].
Antibacterial agent 345 (0-100 μg/mL; 24 h) exhibits no cytotoxicity against HepG2 and J774A cells, with a selectivity index >1666.67 for both cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.