PqsR/LasR-IN-1
Based on 1 Customer Validation
PqsR/LasR-IN-1 (compound 2a) is a potent PqsR and LasR systems inhibitor. PqsR/LasR-IN-1 has anti-virulence activity against Pseudomonas aeruginosa. PqsR/LasR-IN-1 can reduce production of biofilm, pyocyanin, and rhamnolipids in PA.
For research use only. We do not sell to patients.
- Purity: 98.13%
- CAS No.: 924818-33-7
- Formula: C24H20ClNO3
- Molecular Weight:405.87
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Pseudomonas aeruginosa[1]
Chemical Information
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CAS No. 924818-33-7
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Appearance Solid
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Molecular Weight 405.87
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Formula C24H20ClNO3
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Color White to off-white
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SMILES
CC1=C(C=C(C=C1)NC(C2=CC3=C(C(OC(C3)C4=CC=C(C=C4)Cl)=O)C=C2)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (246.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4638 mL | 12.3192 mL | 24.6384 mL | 61.5961 mL |
| 5 mM | 0.4928 mL | 2.4638 mL | 4.9277 mL | 12.3192 mL | |
| 10 mM | 0.2464 mL | 1.2319 mL | 2.4638 mL | 6.1596 mL | |
| 15 mM | 0.1643 mL | 0.8213 mL | 1.6426 mL | 4.1064 mL | |
| 20 mM | 0.1232 mL | 0.6160 mL | 1.2319 mL | 3.0798 mL | |
| 25 mM | 0.0986 mL | 0.4928 mL | 0.9855 mL | 2.4638 mL | |
| 30 mM | 0.0821 mL | 0.4106 mL | 0.8213 mL | 2.0532 mL | |
| 40 mM | 0.0616 mL | 0.3080 mL | 0.6160 mL | 1.5399 mL | |
| 50 mM | 0.0493 mL | 0.2464 mL | 0.4928 mL | 1.2319 mL | |
| 60 mM | 0.0411 mL | 0.2053 mL | 0.4106 mL | 1.0266 mL | |
| 80 mM | 0.0308 mL | 0.1540 mL | 0.3080 mL | 0.7700 mL | |
| 100 mM | 0.0246 mL | 0.1232 mL | 0.2464 mL | 0.6160 mL |
PqsR/LasR-IN-1 Related Classifications
HY-146327 Related Classifications
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