2. Anti-infection
  3. Bacterial Antibiotic
  4. PqsR/LasR-IN-3

PqsR/LasR-IN-3 (Compound 7a) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-3 also inhibits hERG with the IC50 of 109.01 µM.

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PqsR/LasR-IN-3 Chemical Structure

PqsR/LasR-IN-3 Chemical Structure

CAS No. : 2581109-51-3

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Based on 1 publication(s) in Google Scholar

PqsR/LasR-IN-3 Related Antibodies

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Description

PqsR/LasR-IN-3 (Compound 7a) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-3 also inhibits hERG with the IC50 of 109.01 µM[1].

IC50 & Target

PqsR, LasR[1]
Molecular Weight

311.35

Formula

C14H17NO5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1CCOC1=O)CCCS(=O)(C2=CC=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (321.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2118 mL 16.0591 mL 32.1182 mL
5 mM 0.6424 mL 3.2118 mL 6.4236 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2118 mL 16.0591 mL 32.1182 mL 80.2955 mL
5 mM 0.6424 mL 3.2118 mL 6.4236 mL 16.0591 mL
10 mM 0.3212 mL 1.6059 mL 3.2118 mL 8.0295 mL
15 mM 0.2141 mL 1.0706 mL 2.1412 mL 5.3530 mL
20 mM 0.1606 mL 0.8030 mL 1.6059 mL 4.0148 mL
25 mM 0.1285 mL 0.6424 mL 1.2847 mL 3.2118 mL
30 mM 0.1071 mL 0.5353 mL 1.0706 mL 2.6765 mL
40 mM 0.0803 mL 0.4015 mL 0.8030 mL 2.0074 mL
50 mM 0.0642 mL 0.3212 mL 0.6424 mL 1.6059 mL
60 mM 0.0535 mL 0.2677 mL 0.5353 mL 1.3383 mL
80 mM 0.0401 mL 0.2007 mL 0.4015 mL 1.0037 mL
100 mM 0.0321 mL 0.1606 mL 0.3212 mL 0.8030 mL
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PqsR/LasR-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PqsR/LasR-IN-32581109-51-3BacterialAntibioticAnti-virulenceP. aeruginosaCiprofloxacinPqsRLasRhERG Inhibitorinhibitorinhibit

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