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Cat. No.: HY-126258

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IMP-1700

IMP-1700 is a potent DNA damage potentiator and antibacterial agent. IMP-1700 inhibits the bacterial SOS response to DNA damage. IMP-1700 potently sensitizes MRSA to Ciprofloxacin (HY-B0356) with an EC₅₀ of 5.9 nM. IMP-1700 inhibits the growth of E. coli K-12 BW25113, S. aureus SH1000 and MRSA USA300 JE2.

For research use only. We do not sell to patients.

CAS No.: 1458674-25-3
Formula: C₂₅H₂₂F₄N₄O₃S
Molecular Weight:534.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IMP-1700 Chemical Structure

CAS No.: 1458674-25-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

IMP-1700 (18 h) inhibits the growth of E. coli K-12 BW25113, S. aureus SH1000 and MRSA USA300 JE2, and potently sensitizes MRSA to Ciprofloxacin (HY-B0356) with an EC₅₀ of 5.9 ± 0.6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1458674-25-3
Molecular Weight 534.53
Formula C₂₅H₂₂F₄N₄O₃S
SMILES

O=C(O)C1=CN(C2=CC(=C(F)C=C2C1=O)N3CCN(C(=S)NC4=CC=C(C=C4)C(F)(F)F)CC3)C5CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lim CSQ, et al. Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus. Bioorg Med Chem. 2019;27(20):114962. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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IMP-1700

High-Throughput Bioactive Compound Library

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IMP-1700 Related Classifications

HY-126258 Related Classifications