1458674-25-3
Chemical Structure
IMP-1700
- CAS No.: 1458674-25-3
- Formula:C25H22F4N4O3S
- Molecular Weight:534.53
IUPAC Name: 1-cyclopropyl-6-fluoro-4-oxo-7-(4-((4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
InChIKey: DMUZWIXJZNKJPP-UHFFFAOYSA-N
SMILES: O=C(O)C1=CN(C2=CC(=C(F)C=C2C1=O)N3CCN(C(=S)NC4=CC=C(C=C4)C(F)(F)F)CC3)C5CC5
Biological Activity: IMP-1700 is a potent DNA damage potentiator and antibacterial agent. IMP-1700 inhibits the bacterial SOS response to DNA damage. IMP-1700 potently sensitizes MRSA to Ciprofloxacin (HY-B0356) with an EC50 of 5.9 nM. IMP-1700 inhibits the growth of E. coli K-12 BW25113, S. aureus SH1000 and MRSA USA300 JE2[1][2].
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IMP-1700 | IMP-1700 is a potent DNA damage potentiator and antibacterial agent. IMP-1700 inhibits the bacterial SOS response to DNA damage. IMP-1700 potently sensitizes MRSA to Ciprofloxacin (HY-B0356) with an EC50 of 5.9 nM. IMP-1700 inhibits the growth of E. coli K-12 BW25113, S. aureus SH1000 and MRSA USA300 JE2. | |||||||||||||||||||||
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