Plantaricin A
Based on 1 Customer Validation
Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. Plantaricin A shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells[1][2].
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.98%
- CAS. Nr.: 131463-18-8
- Formel: C140H222N36O34S
- Molecular Weight:2985.55
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Plantaricin A (12.5 μg/mL, 12 h) enhances the activity of Ciprofloxacin (CIP) (HY-B0356) and Trimethoprim (HY-B0510) in ATCC 29213, which effectively inhibits the growth of S. aureus at sublethal concentrations[1]. Plantaricin A (12.5 μg/mL, 2 h) increases the membrane potential of S. aureus and the level of intracellular ROS[1]. Plantaricin A (12.5 μg/mL) exerts a synergistic effect with CIP in S. aureus by inhibiting the function of efflux pumps[1]. Plantaricin A (1-50 μM, 60 min) induces the cell death in the cancerous lymphoid Reh, Jurkat cells, normal B and T cells dose-dependently[2]. Plantaricin A (20-50 μM, 50 s) induces a rapidly developing membrane permeabilization followed by membrane disruption or cell lysis in PC12 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-week-old male BALB/c mice were inoculated with 109 CFU/mouse of S. aureus-NorA on the wound surface[1].
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Dosage:12.5 μg/mL combined with CIP (4 μg/mL)
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Administration:Daily applied to the surface of the wound for 7 days
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Result:Showed significantly smaller and thinner scar tissues.
Decreased the level of TNF-α, IL-6, and CRP.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 131463-18-8
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Appearance Solid
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Molecular Weight 2985.55
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Formel C140H222N36O34S
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Color White to off-white
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Synonyms
PlnA
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Sequence
Lys-Ser-Ser-Ala-Tyr-Ser-Leu-Gln-Met-Gly-Ala-Thr-Ala-Ile-Lys-Gln-Val-Lys-Lys-Leu-Phe-Lys-Lys-Trp-Gly-Trp
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Sequence Shortening
KSSAYSLQMGATAIKQVKKLFKKWGW
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 50 mg/mL (16.75 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Meng F, et al. Plantaricin A reverses resistance to ciprofloxacin of multidrug-resistant Staphylococcus aureus by inhibiting efflux pumps. Environ Microbiol. 2022 Oct;24(10):4818-4833. [Content Brief]
[2]. Sand SL, et al. Plantaricin A, a peptide pheromone produced by Lactobacillus plantarum, permeabilizes the cell membrane of both normal and cancerous lymphocytes and neuronal cells. Peptides. 2010 Jul;31(7):1237-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 0.3349 mL | 1.6747 mL | 3.3495 mL | 8.3737 mL |
| 5 mM | 0.0670 mL | 0.3349 mL | 0.6699 mL | 1.6747 mL | |
| 10 mM | 0.0335 mL | 0.1675 mL | 0.3349 mL | 0.8374 mL | |
| 15 mM | 0.0223 mL | 0.1116 mL | 0.2233 mL | 0.5582 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Plantaricin A Related Classifications
HY-P5589 Related Classifications
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