Plantaricin A
Based on 1 Customer Validation
Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. Plantaricin A shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells[1][2].
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.98%
- CAS 番号: 131463-18-8
- 分子式: C140H222N36O34S
- 分子量:2985.55
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Plantaricin A (12.5 μg/mL, 12 h) enhances the activity of Ciprofloxacin (CIP) (HY-B0356) and Trimethoprim (HY-B0510) in ATCC 29213, which effectively inhibits the growth of S. aureus at sublethal concentrations[1]. Plantaricin A (12.5 μg/mL, 2 h) increases the membrane potential of S. aureus and the level of intracellular ROS[1]. Plantaricin A (12.5 μg/mL) exerts a synergistic effect with CIP in S. aureus by inhibiting the function of efflux pumps[1]. Plantaricin A (1-50 μM, 60 min) induces the cell death in the cancerous lymphoid Reh, Jurkat cells, normal B and T cells dose-dependently[2]. Plantaricin A (20-50 μM, 50 s) induces a rapidly developing membrane permeabilization followed by membrane disruption or cell lysis in PC12 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-week-old male BALB/c mice were inoculated with 109 CFU/mouse of S. aureus-NorA on the wound surface[1].
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Dosage:12.5 μg/mL combined with CIP (4 μg/mL)
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Administration:Daily applied to the surface of the wound for 7 days
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Result:Showed significantly smaller and thinner scar tissues.
Decreased the level of TNF-α, IL-6, and CRP.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 131463-18-8
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性状 Solid
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分子量 2985.55
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分子式 C140H222N36O34S
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Color White to off-white
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別名
PlnA
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配列
Lys-Ser-Ser-Ala-Tyr-Ser-Leu-Gln-Met-Gly-Ala-Thr-Ala-Ile-Lys-Gln-Val-Lys-Lys-Leu-Phe-Lys-Lys-Trp-Gly-Trp
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シーケンスの短縮
KSSAYSLQMGATAIKQVKKLFKKWGW
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : 50 mg/mL (16.75 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Meng F, et al. Plantaricin A reverses resistance to ciprofloxacin of multidrug-resistant Staphylococcus aureus by inhibiting efflux pumps. Environ Microbiol. 2022 Oct;24(10):4818-4833. [Content Brief]
[2]. Sand SL, et al. Plantaricin A, a peptide pheromone produced by Lactobacillus plantarum, permeabilizes the cell membrane of both normal and cancerous lymphocytes and neuronal cells. Peptides. 2010 Jul;31(7):1237-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3349 mL | 1.6747 mL | 3.3495 mL | 8.3737 mL |
| 5 mM | 0.0670 mL | 0.3349 mL | 0.6699 mL | 1.6747 mL | |
| 10 mM | 0.0335 mL | 0.1675 mL | 0.3349 mL | 0.8374 mL | |
| 15 mM | 0.0223 mL | 0.1116 mL | 0.2233 mL | 0.5582 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Plantaricin A 関連分類
HY-P5589 関連分類
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