2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Heme Oxygenase (HO)
  4. Antibacterial agent 344

Antibacterial agent 344 is an antibacterial agent with potent biofilm inhibition (IC50 = 0.27 μM). Antibacterial agent 344 inhibits heme oxygenase (HemO), impairs iron homeostasis, virulence factor production, and motility. Antibacterial agent 344 synergizes with Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441), enhancing their efficacy and delaying the development of resistance. Antibacterial agent 344 improves bacterial-infected Galleria mellonella survival, and reduces bacterial load in mice wounds. Antibacterial agent 344 can be used for the research of Pseudomonas aeruginosa infections.

For research use only. We do not sell to patients.

Antibacterial agent 344

Antibacterial agent 344 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Antibacterial agent 344 Related Antibodies

Top Publications Citing Use of Products

View All Heme Oxygenase (HO) Isoform Specific Products:

View All Isoforms
HO-1 HO-2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Antibacterial agent 344 is an antibacterial agent with potent biofilm inhibition (IC50 = 0.27 μM). Antibacterial agent 344 inhibits heme oxygenase (HemO), impairs iron homeostasis, virulence factor production, and motility. Antibacterial agent 344 synergizes with Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441), enhancing their efficacy and delaying the development of resistance. Antibacterial agent 344 improves bacterial-infected Galleria mellonella survival, and reduces bacterial load in mice wounds. Antibacterial agent 344 can be used for the research of Pseudomonas aeruginosa infections[1].

In Vitro

Antibacterial agent 344 (Compound 4p) (0.125-2 μM; 16 h) reduces biofilm, elastase production and iron acquisition in Pseudomonas aeruginosa PAO1 in a concentration-dependent manner[1].
Antibacterial agent 344 binds to HemO protein with a Kd of 269.7 nM[1].
Antibacterial agent 344 shows antibiofilm activity against Pseudomonas aeruginosa PA0405, PA0319, PA0730, PA0209, and PA092 with IC50 values of 0.99-7.87 μM[1].
Antibacterial agent 344 shows synergistic effects of with Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 344 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 AUClast AUCinf Tmax Cmax F MRTINF_obs C0 Vd CL
Mice[1] 10 mg/kg i.v. 3.21 h 793 ng·h/mL 813 ng·h/mL / / / 1.34 h 6760 ng/mL 55.4 L/kg 212 mL/min/kg
Mice[1] 10 mg/kg i.p. 3.16 h 659 ng·h/mL 699 ng·h/mL 0.194 h 725 ng/mL 86.0 % 2.41 h / / /
In Vivo

Antibacterial agent 344 (Compound 4p) (2 μM; injection; single dose) increases the survival rate of Galleria mellonella infected with P. aeruginosa PAO1 when co-administered with Ciprofloxacin or Tobramycin[1].
Antibacterial agent 344 (2 μM; topical; once daily; 9 days) reduces P. aeruginosa PAO1 bacterial load and accelerates wound healing in mouse wound infections when co-administered with ciprofloxacin or tobramycin, without causing detectable organ toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: monas aeruginosa wound infected BALB/c mice (female, 3-5 weeks old)[1]
Dosage: 2 μM
Administration: topical; once daily; 9 days
Result: Reduced bacterial load by 2.10 log10 CFU compared to the control and 1.37 log10 CFU compared to ciprofloxacin monotherapy when combined with 0.0008 mg/mL Ciprofloxacin.
Accelerated wound healing compared to control and Ciprofloxacin monotherapy when combined with 0.0008 mg/mL ciprofloxacin.
Reduced bacterial load by 2.11 log10 CFU compared to the control and relative to Tobramycin monotherapy when combined with 0.002 mg/mL Tobramycin.
Accelerated wound healing compared to control and Tobramycin monotherapy when combined with 0.002 mg/mL tobramycin.
Caused no histopathological alterations in heart, liver, spleen, lung, or kidney tissues.
Caused no significant body weight changes.
Molecular Weight

398.46

Formula

C18H14N4O3S2
SMILES

O=C(CN1N=NC(CSC2=NC3=C(S2)C=CC=C3)=C1)C4=CC=C(C(O)=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antibacterial agent 344 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 344Antibacterial agent344Antibacterial agent-344BacterialHeme Oxygenase (HO)Heme OxygenasePseudomonas aeruginosa PAO1Galleria mellonellaelastasemouse wound infectionsheme iron acquisitionbiofilm formationHemOvirulence factor productioniron homeostasisPseudomonas aeruginosaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Antibacterial agent 344
Cat. No.:
HY-183711
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.