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Results for "

endothelin 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endothelin Receptor (35) Angiotensin-converting Enzyme (ACE) (3) Anion Exchangers (1) Apoptosis (1) Carbonic Anhydrase (1) Cathepsin (1) Collagen (1) COX (1) Drug Metabolite (1) Endogenous Metabolite (4) ERK (3) Fluorescent Dye (1) Interleukin Related (1) Isotope-Labeled Compounds (2) MMP (1) NF-κB (1) NO Synthase (1) Prostaglandin Receptor (2) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) TGF-β Receptor (1) TNF Receptor (1) Vasopressin Receptor (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (45) Endocrinology (13) Inflammation/Immunology (6) Metabolic Disease (7)

By Targets:

Endothelin Receptor (35)

Angiotensin-converting Enzyme (ACE) (3)

Anion Exchangers (1)

Apoptosis (1)

Carbonic Anhydrase (1)

Cathepsin (1)

Collagen (1)

COX (1)

Drug Metabolite (1)

Endogenous Metabolite (4)

ERK (3)

Fluorescent Dye (1)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

MMP (1)

NF-κB (1)

NO Synthase (1)

Prostaglandin Receptor (2)

Radionuclide-Drug Conjugates (RDCs) (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

TGF-β Receptor (1)

TNF Receptor (1)

Vasopressin Receptor (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (45)

Endocrinology (13)

Inflammation/Immunology (6)

Metabolic Disease (7)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Endothelin Receptor Endothelin-Converting Enzyme (ECE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0202

Endothelin 1 (swine, human) Maximum Cited Publications 9 Publications Verification ET-1 (swine, human)	Endothelin Receptor	Metabolic Disease Inflammation/Immunology
Endothelin 1 (swine, human) (ET-1) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-113046

5-Methyltetrahydrofolic acid 5+ Cited Publications 5-Methyl THF; 5-MTHF	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .

HY-A0013

Bosentan Maximum Cited Publications 32 Publications Verification	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-P4159

Endothelin-1 (1-31) (Human) 1 Publications Verification	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase .

HY-12378

BQ-123 4 Publications Verification	Endothelin Receptor	Cardiovascular Disease
BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC₅₀ of 7.3 nM and a K_i of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .

HY-P1235A

Carperitide acetate 3 Publications Verification Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits *endothelin-1* secretion in a dose-dependent way.

HY-A0013A

Bosentan hydrate Maximum Cited Publications 32 Publications Verification	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-P1236

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Atrial natriuretic factor (1-28) (rat, mouse)	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated *endothelin-1* secretion in a concentration-dependent manner.

HY-P4159A

Endothelin-1 (1-31) (Human) TFA 1 Publications Verification	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) TFA is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) TFA is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P3615

*[Asn18] Endothelin-1* (swine, human)**	Endothelin Receptor	Cardiovascular Disease
[Asn18] Endothelin-1 swine, human is a structural analogue of Endothelin 1 (swine, human) (HY-P0202), with the Asp amino acid at position 18 mutated to Asn. Endothelin 1 (swine, human) is a synthetic peptide with human and porcine endothelin 1 sequences and is a potent endogenous vasoconstrictor .

HY-P2538

*Big Endothelin-1* (1-38), human**	Vasopressin Receptor	Cardiovascular Disease
Big Endothelin-1 (1-38), human is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide .

HY-P0202A

Endothelin 1 (swine, human) TFA Maximum Cited Publications 9 Publications Verification ET-1 (swine, human) TFA	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human) (ET-1) TFA is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 TFA acts through two types of receptors ET_A and ET_B .

HY-W042301

Xipamide	Anion Exchangers Carbonic Anhydrase Endothelin Receptor	Cardiovascular Disease
Xipamide is an orally active carbonic anhydrase (CA) inhibitor and Na ⁺/Cl ^--potassium transporter inhibitor with diuretic and antihypertensive effects. Xipamide reduces NaCl reabsorption by inhibiting the Cl ^-/NaCO₃ ^- anion exchanger, and increases calcium reabsorption while promoting potassium and magnesium excretion. Xipamide is mainly cleared via the renal pathway and causes a temporary decrease in glomerular filtration rate under specific conditions. Xipamide does not affect Ca ²⁺ signaling induced by endothelin-1 and other factors, nor does it inhibit various ion cotransport or pump activities in red blood cells. Xipamide can be used in researches related to cardiovascular diseases, hypertension (especially with left ventricular hypertrophy), advanced renal failure, and liver cirrhosis with ascites .

HY-P1236A

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA Atrial natriuretic factor (1-28) (rat, mouse) TFA	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated *endothelin-1* secretion in a concentration-dependent manner.

HY-P2496

Endothelin 1 (swine, human), Alexa Fluor 488-labeled	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of ETA/ETB receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-P3733

*Big Endothelin-1* (22-38), human**	Endothelin Receptor	Cardiovascular Disease
Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38) .

HY-P4641

H-Trp-Phe-OH Trp-Phe	Angiotensin-converting Enzyme (ACE) Endothelin Receptor	Cardiovascular Disease
H-Trp-Phe-OH (Trp-Phe) is an ACE inhibitor and endothelial function regulator, with an ACE IC₅₀ of 0.318 mg/mL. H-Trp-Phe-OH increases nitric oxide concentration, reduces endothelin-1 (ET-1) levels, and reverses norepinephrine-mediated endothelial cell dysfunction. H-Trp-Phe-OH exhibits antihypertensive activity. H-Trp-Phe-OH can be used in studies related to hypertension and atherosclerosis .

HY-P11112

PTD-DBM	β-catenin Wnt Collagen	Inflammation/Immunology
PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a Wnt/β-catenin pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing .

HY-P4159B

Endothelin-1 (1-31) (Human) acetate	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) acetate is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) acetate is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P1235

Carperitide Atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits *endothelin-1* secretion in a dose-dependent way.

HY-113046S1

5-Methyltetrahydrofolic acid-13C6 5-Methyl THF-¹³C₆; 5-MTHF-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
5-Methyltetrahydrofolic acid- ¹³C₆ (5-Methyl THF- ¹³C₆) is ¹³C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .

HY-P2539

*Big Endothelin-1* (1-39), porcine**	Vasopressin Receptor	Cardiovascular Disease
Big Endothelin-1 (1-39), porcine is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide. Big Endothelin-1 (1-39), porcine has similar pressor effects in vivo .

HY-P5130

*Big endothelin-1* (rat 1-39)**	Endothelin Receptor	Cardiovascular Disease
Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice .

HY-19890

Aminaftone Aminaftone; Aminaphthone	Endothelin Receptor	Cardiovascular Disease Endocrinology
Aminaftone, a derivative of 4-aminobenzoic acid, downregulates *endothelin-1* (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene.

HY-P3610

*[Ala18] Endothelin-1, human*	Endothelin Receptor	Others
[Ala18] Endothelin-1, human is a biologically active peptide. [Ala18] Endothelin-1, human can be used for the research of various biochemical studies.

HY-76520

Sitaxsentan IPI 1040; TBC-11251	Endothelin Receptor TGF-β Receptor	Cardiovascular Disease Metabolic Disease
Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC₅₀ of 1.4 nM and a K_i of 0.43 nM. Sitaxsentan exhibits an IC₅₀ for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .

HY-106994A

Nebentan potassium YM598	Endothelin Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ET_A receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [ ¹²⁵I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K_i of 0.697 nM and 569 nM, respectively . YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo .

HY-133829

Zofenoprilat	Angiotensin-converting Enzyme (ACE) NO Synthase Reactive Oxygen Species (ROS)	Cardiovascular Disease
Zofenoprilat is an angiotensin-converting enzyme (ACE) inhibitor with an IC₅₀ of 1.7 nM. Zofenoprilat exerts cardioprotective and renoprotective effects by inhibiting angiotensin II expression and lowering blood pressure. Zofenoprilat promotes NO production and reduces endothelin-1 (ET-1) expression. Zofenoprilat decreases TNFα-induced ROS production and protects vascular endothelial function. Zofenoprilat regulates oxidative stress-related molecules and possesses antioxidant activity. Zofenoprilat can be used in studies related to hypertension and congestive heart failure .

HY-P1019

*[Ala1,3,11,15]-Endothelin* (53-63)**	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) can be used for the research of vasoconstriction

HY-115417

Bosentan-d4	Endothelin Receptor	Cardiovascular Disease Endocrinology
Bosentan-d4 is the deuterium labeled Bosentan. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-10383

J-104132	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
J-104132 (L-753037) is a potent, orally active, selective and competitive ETA/ETB receptor antagonist with K_i of 0.034 nM for ETA and 0.104 nM for ETB receptors. J-104132 inhibits Endothelin-1 (ET-1) (HY-P71446)-induced signaling and vascular contractions in vitro. J-104132 alleviates hypertension, vascular remodeling, and diabetic endothelial dysfunction in vivo by dual ETA/ETB blockade. J-104132 can be used for research on diabetic vascular complications ^[1][3].

HY-135283

ABT-546 A-216546	Endothelin Receptor	Cardiovascular Disease Endocrinology
ABT-546 (A-216546), a chemical probe, is a potent, highly selective and active endothelin ET_A receptor antagonist with a K_i of 0.46 nM for [ ¹²⁵I]endothelin-1 binding to cloned *human endothelin* ET_A. ABT-546 is >25,000-fold more selective for the ET_A receptor** than for the ET_B receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC₅₀ of 0.59 nM and 3 nM, respectively .

HY-10282

Daglutril	Endothelin Receptor	Others
Daglutril is a compound with the potential to regulate cytokine-induced endothelin-1 production in astrocytes. In studies, it has an inhibitory effect on the production of endothelin-1 induced by some cytokines and can be used as a tool to screen compounds that inhibit endothelin-1 production in astrocytes.

HY-A0013AR

Bosentan hydrate (Standard)	Reference Standards Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan (hydrate) (Standard) is the analytical standard of Bosentan (hydrate). This product is intended for research and analytical applications. Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.

HY-102092

FR139317 PD 147953	Endothelin Receptor	Cardiovascular Disease
FR139317 (PD 147953) is a selective ET_A receptor antagonist. FR139317 inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. FR139317 also ameliorates cerebral vasospasm in dogs .

HY-118294

15-OH Tafluprost 16-Phenoxy tetranor prostaglandin F2α isopropyl ester; 16-Phenoxy tetranor PGF2α isopropyl ester	Prostaglandin Receptor	Cardiovascular Disease
15-OH Tafluprost, a prostaglandin F2a (PGF2a) analog, relieves endothelin-1 (ET-1)-induced optic nerve head (ONH) blood flow impairment and ET-1-induced contraction of isolated ciliary artery segments .

HY-106994

Nebentan YM598 free base	Endothelin Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ET_A receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [ ¹²⁵I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K_i of 0.697 nM and 569 nM, respectively . YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo .

HY-N5170

Aselacin A	Endothelin Receptor	Cardiovascular Disease
Aselacin A targets endothelin-1 receptor (ET-1 receptor), inhibits the the binding of ET-1 to ETA receptor and ETB receptor. Aselacin A inhibits the ET-1 binding to bovine atrial membrane and porcine cerebral membrane with IC₅₀ of 22 μg/mL and 20 μg/mL. Aselacin A can be used for research of cardiovascular diseases .

HY-135390

Hydroxy desmethyl Bosentan Ro 64-1056	Drug Metabolite	Cardiovascular Disease
Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver . Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension .

HY-18211

CGS 35601	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC₅₀s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats .

HY-P1019A

*[Ala1,3,11,15]-Endothelin* (53-63) TFA**	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction .

HY-12378A

BQ-123 TFA	Endothelin Receptor	Cardiovascular Disease
BQ-123 TFA is a potent and selective endothelin A (ETA) receptor antagonist with an IC₅₀ of 7.3 nM and a K_i of 25 nM. BQ-123 TFA inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .

HY-125386

SQ 32056	Cathepsin	Cardiovascular Disease
SQ 32056 is a cathepsin E inhibitor. SQ 32056 can block the pressor response to endothelin .

HY-117814

BMS-187308	Endothelin Receptor	Cardiovascular Disease
BMS-187308 is an orally active endothelin-A (ETA) antagonist, with K_is of 4.7 nM for ETA and 1.7 μM for ETB. BMS-187308 inhibits the pressor response to ET-1 (ED₂₅: 1.2 µmol/kg; iv). BMS-187308 is a suitable tool for investigating the role of endothelin .

HY-78096

O-Deshydroxyethyl bosentan	Endogenous Metabolite	Metabolic Disease
O-Deshydroxyethyl bosentan is a metabolite of Bosentan (HY-A0013), which is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors .

HY-106994AR

Nebentan potassium (Standard) YM598 (Standard)	Reference Standards Endothelin Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Nebentan potassium (Standard) (GT-2331 maleate (Standard)) is the analytical standard of Nebentan (potassium) (HY-106994A). This product is intended for research and analytical applications. Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K_i of 0.697 nM and 569 nM, respectively . YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo .

HY-113046S2

5-Methyltetrahydrofolic acid-d4 5-Methyl THF-d₄; 5-MTHF-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
5-Methyltetrahydrofolic acid-d₄ (5-Methyl THF-d₄) is the deuterium labeled 5-Methyltetrahydrofolic acid (HY-113046). 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .

HY-135446

BQ-610	Endothelin Receptor	Cardiovascular Disease Endocrinology
BQ-610 is a selective antagonist of the endothelin A receptor (ETA receptor). BQ-610 specifically blocks the ETA receptor, competitively inhibiting the binding of endothelin-1 (ET-1) (a vasoconstrictive peptide) to the receptor, thereby blocking the effects of ET-1 such as vascular smooth muscle contraction, cell mitosis, and inhibition of hormone secretion. BQ-610 significantly alleviates cerebral vasospasm in rabbits. BQ-610 blocks the bronchial epithelial and pulmonary vascular cell proliferation caused by cigarette smoke in rat models. BQ-610 can delay the natural luteal regression in the cow's uterus. BQ-610 can be used for research on vasospasm, abnormal cell proliferation, and reproductive endocrine disorders .

HY-182561

Cgs 27830	Endothelin Receptor	Cardiovascular Disease
Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs .

HY-136785

PD151242	Endothelin Receptor Radionuclide-Drug Conjugates (RDCs)	Cardiovascular Disease
PD151242 is a selective competitive antagonist of the endothelin ET_A receptor, with K_D values of 0.65 nM, 0.64 nM and 1.92 nM for human, rat and porcine receptors, respectively, and a K_D value of 104 μM for the human ET_β receptor. When radiolabeled as [ ¹²⁵I]-PD151242, PD151242 can be used to visualize and localize renal vascular ET_A receptors .

Cat. No.	Product Name	Target	Research Area

HY-P0202

Endothelin 1 (swine, human) Maximum Cited Publications 9 Publications Verification ET-1 (swine, human)	Endothelin Receptor	Metabolic Disease Inflammation/Immunology
Endothelin 1 (swine, human) (ET-1) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-P4159

Endothelin-1 (1-31) (Human) 1 Publications Verification	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase .

HY-12378

BQ-123 4 Publications Verification	Endothelin Receptor	Cardiovascular Disease
BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC₅₀ of 7.3 nM and a K_i of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .

HY-P1235A

Carperitide acetate 3 Publications Verification Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits *endothelin-1* secretion in a dose-dependent way.

HY-P1236

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Atrial natriuretic factor (1-28) (rat, mouse)	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated *endothelin-1* secretion in a concentration-dependent manner.

HY-P4159A

Endothelin-1 (1-31) (Human) TFA 1 Publications Verification	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) TFA is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) TFA is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P3615

*[Asn18] Endothelin-1* (swine, human)**	Endothelin Receptor	Cardiovascular Disease
[Asn18] Endothelin-1 swine, human is a structural analogue of Endothelin 1 (swine, human) (HY-P0202), with the Asp amino acid at position 18 mutated to Asn. Endothelin 1 (swine, human) is a synthetic peptide with human and porcine endothelin 1 sequences and is a potent endogenous vasoconstrictor .

HY-P2538

*Big Endothelin-1* (1-38), human**	Vasopressin Receptor	Cardiovascular Disease
Big Endothelin-1 (1-38), human is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide .

HY-P0202A

Endothelin 1 (swine, human) TFA Maximum Cited Publications 9 Publications Verification ET-1 (swine, human) TFA	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human) (ET-1) TFA is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 TFA acts through two types of receptors ET_A and ET_B .

HY-P1236A

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA Atrial natriuretic factor (1-28) (rat, mouse) TFA	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated *endothelin-1* secretion in a concentration-dependent manner.

HY-P2496

Endothelin 1 (swine, human), Alexa Fluor 488-labeled	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of ETA/ETB receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-P3733

*Big Endothelin-1* (22-38), human**	Endothelin Receptor	Cardiovascular Disease
Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38) .

HY-P4641

H-Trp-Phe-OH Trp-Phe	Angiotensin-converting Enzyme (ACE) Endothelin Receptor	Cardiovascular Disease
H-Trp-Phe-OH (Trp-Phe) is an ACE inhibitor and endothelial function regulator, with an ACE IC₅₀ of 0.318 mg/mL. H-Trp-Phe-OH increases nitric oxide concentration, reduces endothelin-1 (ET-1) levels, and reverses norepinephrine-mediated endothelial cell dysfunction. H-Trp-Phe-OH exhibits antihypertensive activity. H-Trp-Phe-OH can be used in studies related to hypertension and atherosclerosis .

HY-P11112

PTD-DBM	β-catenin Wnt Collagen	Inflammation/Immunology
PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a Wnt/β-catenin pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing .

HY-P4159B

Endothelin-1 (1-31) (Human) acetate	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) acetate is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) acetate is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P4912

*Big Endothelin-1* (rat)**	Peptides	Others
Big Endothelin-1 (rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3569

*[D-Val22, Phe33] Big Endothelin-1* (16-38), human**	Peptides	Others
[D-Val22, Phe33] Big Endothelin-1 (16-38), human is a polypeptide.

HY-P1235

Carperitide Atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits *endothelin-1* secretion in a dose-dependent way.

HY-P2539

*Big Endothelin-1* (1-39), porcine**	Vasopressin Receptor	Cardiovascular Disease
Big Endothelin-1 (1-39), porcine is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide. Big Endothelin-1 (1-39), porcine has similar pressor effects in vivo .

HY-P5130

*Big endothelin-1* (rat 1-39)**	Endothelin Receptor	Cardiovascular Disease
Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice .

HY-P3610

*[Ala18] Endothelin-1, human*	Endothelin Receptor	Others
[Ala18] Endothelin-1, human is a biologically active peptide. [Ala18] Endothelin-1, human can be used for the research of various biochemical studies.

HY-P1019

*[Ala1,3,11,15]-Endothelin* (53-63)**	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) can be used for the research of vasoconstriction

HY-P3614

*[Ala3,11,18, Nle7] Endothelin-1, human*	Peptides	Others
[Ala3,11,18, Nle7] Endothelin-1, human is a synthetic peptide.

HY-P1019A

*[Ala1,3,11,15]-Endothelin* (53-63) TFA**	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113046

5-Methyltetrahydrofolic acid 5+ Cited Publications 5-Methyl THF; 5-MTHF	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .

HY-N5170

Aselacin A	Natural Products Microorganisms Source Classification	Endothelin Receptor
Aselacin A targets endothelin-1 receptor (ET-1 receptor), inhibits the the binding of ET-1 to ETA receptor and ETB receptor. Aselacin A inhibits the ET-1 binding to bovine atrial membrane and porcine cerebral membrane with IC₅₀ of 22 μg/mL and 20 μg/mL. Aselacin A can be used for research of cardiovascular diseases .

Species:	Human (1) Rat (1)
Tag:	KSI (1) His (1) GST (1)
Source:	E. coli (2)

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HY-P71446

	Endothelin-1/EDN1 Protein, Rat (His-KSI) 4 Publications Verification Edn1; endothelin-1; ET-1; Preproendothelin-1; PPET1	Rat	E. coli
	Endothelin-1/Edn1 protein is an endothelium-derived vasoconstrictor peptide that plays a crucial role in vascular regulation.As a possible ligand of the G protein-coupled receptors EDNRA and EDNRB, it initiates a signaling cascade involving PTK2B, BCAR1, BCAR3 and the GTPases RAP1 and RHOA in glomerular mesangial cells, helping to regulate vascular tone.Endothelin-1/EDN1 Protein, Rat (His-KSI) is the recombinant rat-derived Endothelin-1/EDN1 protein, expressed by E.coli , with N-6*His, N-KSI labeled tag.

HY-P700460

	Endothelin-1/EDN1 Protein, Human (GST) 1 Publications Verification Preproendothelin-1 ; PPET1	Human	E. coli
	Endothelin-1/EDN1, an endothelium-derived vasoconstrictor peptide, acts as a likely ligand for G-protein coupled receptors EDNRA and EDNRB. Its binding initiates a signaling cascade in glomerular mesangial cells involving PTK2B, BCAR1, BCAR3, and GTPases RAP1 and RHOA. Furthermore, Endothelin-1/EDN1 shows binding affinity for the DEAR/FBXW7-AS1 receptor, underscoring its involvement in diverse cellular signaling and vascular regulation. Endothelin-1/EDN1 Protein, Human (GST) is the recombinant human-derived Endothelin-1/EDN1 protein, expressed by E. coli , with N-GST labeled tag.

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HY-113046S1

5-Methyltetrahydrofolic acid-13C6

5-Methyltetrahydrofolic acid- ¹³C₆ (5-Methyl THF- ¹³C₆) is ¹³C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .

HY-113046S2

5-Methyltetrahydrofolic acid-d4

5-Methyltetrahydrofolic acid-d₄ (5-Methyl THF-d₄) is the deuterium labeled 5-Methyltetrahydrofolic acid (HY-113046). 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .

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HY-P811187

	Endothelin A Receptor Antibody ETA, ETRA, EDNRA, endothelin-1 receptor, endothelin receptor type A, ET-A, ETA-R, hET-AR	WB, ICC/IF	Human, Mouse
	Endothelin A Receptor Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Endothelin A Receptor.

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