2. GPCR/G Protein
  3. Endothelin Receptor
  4. Cgs 27830

Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs.

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Cgs 27830

Cgs 27830 Chemical Structure

CAS No. : 155485-56-6

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Description

Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs[1].

In Vivo

CGS 27830 (100 mcg/min; intrapulmonary infusion; 10 min) does not alter basal pulmonary vascular tone in late gestation fetal lambs but completely blocks big-ET-1-induced pulmonary vasoconstriction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Columbia-Rambouillet (mixed breed, late gestation 131 days)[1]
Dosage: 100 mcg/min
Administration: intrapulmonary infusion; 10 min
Result: Did not alter baseline left pulmonary artery flow, mean pulmonary artery pressure, mean aortic pressure, left atrial pressure, pulmonary vascular resistance, heart rate, or blood gas parameters.
Blocked the big-ET-1-induced increase in pulmonary vascular resistance.
Blocked the big-ET-1-induced rise in mean pulmonary artery pressure.
Prevented changes in left pulmonary artery flow.
Molecular Weight

646.60

Formula

C32H30N4O11
CAS No.
SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)OC(C3=C(C)NC(C)=C(C(OC)=O)[C@H]3C4=CC([N+]([O-])=O)=CC=C4)=O
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Purity & Documentation
References
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Cgs 27830 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cgs 27830155485-56-6Cgs27830Cgs-27830Endothelin Receptorovine fetal pulmonary circulationendothelin receptor antagonistET-B receptorslate gestation fetal lambsbig-endothelin-1ET-A receptorspulmonary vasoconstrictionInhibitorinhibitorinhibit

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Cgs 27830
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