155485-56-6
155485-56-6
Chemical Structure
Cgs 27830
- CAS No.: 155485-56-6
- Formula:C32H30N4O11
- Molecular Weight:646.60
InChIKey: PZNZOWSLQRURNA-HNRBIFIRSA-N
SMILES: O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)OC(C3=C(C)NC(C)=C(C(OC)=O)[C@H]3C4=CC([N+]([O-])=O)=CC=C4)=O
Biological Activity: Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs[1].
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Cgs 27830 | Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs. | |||||||||||||||||||||
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