1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Hydroxy desmethyl Bosentan

Hydroxy desmethyl Bosentan (Synonyms: Ro 64-1056)

Cat. No.: HY-135390
Handling Instructions

Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension.

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Hydroxy desmethyl Bosentan Chemical Structure

Hydroxy desmethyl Bosentan Chemical Structure

CAS No. : 253688-62-9

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Description

Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver[1]. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension[2].

Molecular Weight

553.59

Formula

C₂₆H₂₇N₅O₇S

CAS No.

253688-62-9

SMILES

O=S(C1=CC=C(C(C)(C)CO)C=C1)(NC2=NC(C3=NC=CC=N3)=NC(OCCO)=C2OC4=CC=CC=C4O)=O

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Keywords:

Hydroxy desmethyl BosentanRo 64-1056Drug MetaboliteInhibitorinhibitorinhibit

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