1. GPCR/G Protein
  2. Endothelin Receptor
  3. [Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA)

[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA) 

Cat. No.: HY-P1019A
Handling Instructions

[Ala1,3,11,15]-Endothelin (53-63) (TFA), a linear peptide analog of endothelin (ET)-1, is a highly selective endothelin B (ETB) receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA) Chemical Structure

[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA) Chemical Structure

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Description

[Ala1,3,11,15]-Endothelin (53-63) (TFA), a linear peptide analog of endothelin (ET)-1, is a highly selective endothelin B (ETB) receptor[1].

IC50 & Target[1]

ETB

 

In Vitro

[Ala1,3,11,15]-Endothelin (53-63) (TFA) has IC50s of 0.61 nM, 0.61 nM, 0.33 nM, 2200 nM for ETB in Bronchus, Lung, Cerebellum, VSMC, respectively[1].
[Ala1,3,11,15]-Endothelin (53-63) (TFA) inhibits the specific binding of [125I]ET-1 with IC50s of 0.61 nM in bronchus and lung parenchyma[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2481.70

Formula

C₁₁₁H₁₆₄F₃N₂₅O₃₄S

Sequence

Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp

Sequence Shortening

ASASSLMDKEAVYFAHLDIIW

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA)Endothelin ReceptorlinearpeptideendothelinET-1BETBInhibitorinhibitorinhibit

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Product Name:
[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA)
Cat. No.:
HY-P1019A
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