2. GPCR/G Protein
  3. Endothelin Receptor
  4. [Ala1,​3,​11,​15]​-​Endothelin (53-63) TFA

[Ala1,​3,​11,​15]​-​Endothelin (53-63) TFA 

Cat. No.: HY-P1019A Purity: 98.18%
COA
SDS
Handling Instructions Technical Support

[Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ETB agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ETB with IC50 values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction.

For research use only. We do not sell to patients.

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[Ala1,​3,​11,​15]​-​Endothelin (53-63) TFA

[Ala1,​3,​11,​15]​-​Endothelin (53-63) TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of [Ala1,​3,​11,​15]​-​Endothelin (53-63) TFA:

[Ala1,​3,​11,​15]​-​Endothelin (53-63) TFA Related Antibodies

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Description

[Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ETB agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ETB with IC50 values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction[1].

IC50 & Target[1]

ETB

 

In Vitro

[Ala1,3,11,15]-Endothelin (53-63) (TFA) (0.1 μM) has selectivity for ETB with IC50 values of 0.61 nM, 0.61 nM, 0.33 nM, 2200 nM in Bronchus, Lung, Cerebellum and VSMC, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Ala1,​3,​11,​15]​-​Endothelin (53-63) TFA Related Antibodies
Molecular Weight

2481.70

Formula

C111H164F3N25O34S
Appearance

Solid

Color

White to off-white

Sequence

Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
Sequence Shortening

ASASSLMDKEAVYFAHLDIIW
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (20.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4029 mL 2.0147 mL 4.0295 mL
5 mM 0.0806 mL 0.4029 mL 0.8059 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4029 mL 2.0147 mL 4.0295 mL 10.0737 mL
5 mM 0.0806 mL 0.4029 mL 0.8059 mL 2.0147 mL
10 mM 0.0403 mL 0.2015 mL 0.4029 mL 1.0074 mL
15 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.6716 mL
20 mM 0.0201 mL 0.1007 mL 0.2015 mL 0.5037 mL
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[Ala1,​3,​11,​15]​-​Endothelin (53-63) TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Ala1,​3,​11,​15]​-​Endothelin (53-63)Endothelin ReceptorlinearpeptideendothelinET-1BETBInhibitorinhibitorinhibit

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