[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA) 

[Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ET^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction^[1].

[Ala1,3,11,15]-Endothelin (53-63) (TFA) (0.1 μM) has selectivity for ET^B with IC₅₀ values of 0.61 nM, 0.61 nM, 0.33 nM, 2200 nM in Bronchus, Lung, Cerebellum and VSMC, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2481.70

C₁₁₁H₁₆₄F₃N₂₅O₃₄S

Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp

ASASSLMDKEAVYFAHLDIIW

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nakamichi K, et al. Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1. Biochem Biophys Res Commun. 1992 Jan 15;182(1):144-50.  [Content Brief]