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japonicus

" in MedChemExpress (MCE) Product Catalog:

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Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0515

Ophiopogonin D 1 Publications Verification	PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .

HY-N1073

Wighteone 1 Publications Verification 6-Isopentenylgenistein; Erythrinin B	Apoptosis EGFR HSP ERK Akt	Infection Cancer
Wighteone (6-Isopentenylgenistein; Erythrinin B) is a prenylated isoflavone that acts as a HSP90/EGFR ^L858R/T790M inhibitor and antifungal agent. Wighteone reduces the expression level of HSP90, blocks EGF-induced phosphorylation of EGFR, and thereby inhibits the downstream ERK and AKT signaling pathways. Wighteone induces cell cycle redistribution, inhibits proliferation and triggers apoptosis in cancer cells. Wighteone can be isolated from Erythrina suberosa, and can also be induced to synthesize in Lotus japonicus under specific conditions. Wighteone can be used to study HER2-positive breast cancer, leukemia, non-small cell lung cancer with EGFR ^L858R/T790M mutation, and fungal infections .

HY-N0496

Ruscogenin Maximum Cited Publications 6 Publications Verification	NOD-like Receptor (NLR)	Cardiovascular Disease
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .

HY-N0914

Ajugol 3 Publications Verification	Parasite Autophagy Interleukin Related Reactive Oxygen Species (ROS) mTOR	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Ajugol is an orally active iridoid glycoside found in the traditional Chinese medicine Leonurus japonicus. Ajugol is an autophagy activator. Ajugol activates TFEB-mediated autophagy and lysosomal biogenesis. Ajugol also has anti-inflammatory effects. Ajugol has great potential in the research of asthma, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis .

HY-N5091

Physcion 8-O-β-D-glucopyranoside	Others	Inflammation/Immunology Cancer
Physcion 8-O-β-D-glucopyranosideis an anthraquinone compound isolated from Rumex japonicus* Houtt*. Physcion 8-O-β-D-glucopyranoside exerts anti-inflammatory and anti-cancer properties, can be for common malignancy cancer research .

HY-N2438

Methylophiopogonanone B 2 Publications Verification	Ras Microtubule/Tubulin	Cancer
Methylophiopogonanone B is a homoisoflavonoid compound. Methylophiopogonanone B can be isolated from O. japonicus root. Methylophiopogonanone B promotes Rho activation and Tubulin depolymerization. Methylophiopogonanone B significantly increases GTP-Rho, but not GTP-Rac or GTP-CDC42. Methylophiopogonanone B induces cell morphological change via melanocyte dendrite retraction and stress fiber formation. Methylophiopogonanone B exhibits strong antioxidant activity. Methylophiopogonanone B can be used in the research of cervical cancer .

HY-E70396

Pectolyase Y-23, A. japonicus	Biochemical Assay Reagents	Others
Pectolyase Y-23, A. japonicus is an enzyme derived from Aspergillus japonicas. Pectolyase Y-23, A. japonicus can be used in combination with cellulase to isolate bioactive protoplasts .

HY-N7942

6-Aldehydoisoophiopogonone A	Others	Others
6-Aldehydoisoophiopogonone A is a homoisoflavonoid that can be isolated from Ophiopogon japonicus .

HY-N3505

14-Hydroxy sprengerinin C	Others	Others
14-Hydroxy sprengerinin C is a steroidal compound found in Ophiopogon japonicus.

HY-N7293

Bakkenolide D	Histamine Receptor	Inflammation/Immunology
Bakkenolide D is a sesquiterpene lactone. Bakkenolide D is the major component of Bakkenolides in Petasites tricholobus. Bakkenolide D exhibits anti-allergic and antihistamine activities, and can be used in studies related to allergic rhinitis .

HY-N11985

Ophiopogonone C	Others	Others
Ophiopogonone C (compound 3) is an isoflavone compound isolated from the ethanol extract of Ophiopogon japonicus tubers .

HY-N0515R

Ophiopogonin D (Standard)	Reference Standards PPAR NF-κB Calcium Channel ERK Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .

HY-N2174

Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside	Others	Cardiovascular Disease
Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside, a terpenoid glycoside from Ophiopogon japonicus roots, has good pharmacological effects on the cardiovascular system .

HY-N2516

Ginsenoside Rd2	Others	Inflammation/Immunology
Ginsenoside Rd2 is a saponin found in Panax japonicus with anti-inflammatory actions .

HY-N2175

Cixiophiopogon A	Others	Metabolic Disease
Cixiophiopogon A, a steroidal glycoside, obtained from the tuberous roots of Ophiopogon japonicus (Liliaceae) .

HY-N10912

Shizukanolide	Others	Infection
Shizukanolide, a sesquiterpene lactone, can be isolated from Chloranthus japonicus (Chloranthaceae). The dehydro-compound of Shizukanolide, shows moderate antifungal activity .

HY-N0496R

Ruscogenin (Standard)	Reference Standards NOD-like Receptor (NLR)	Cardiovascular Disease
Ruscogenin (Standard) is the analytical standard of Ruscogenin. This product is intended for research and analytical applications. Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .

HY-N14021

*Petasites japonicus* extract**	DNA/RNA Synthesis	Neurological Disease Inflammation/Immunology Cancer
Petasites japonicus extract is the extract from Petasites japonicus with antioxidant, anti-inflammatory, anti-obesity, neuroprotective and anti-cancer effects. Petasites japonicus extract promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells .

HY-N10601

11-Oxo-α-amyrin Neoilexonol	Others	Others
11-Oxo-α-amyrin (Neoilexonol) is a triterpenoid that can be isolated from Leonurus japonicus (Lamiaceae) .

HY-N16654

Panaxjapyne B	Others	Others
Panaxjapyne B is a polyacetylene compound. Panaxjapyne B can be isolated from roots of P. japonicus* var. major* .

HY-142063

Petasitenine Fukinotoxin	Endogenous Metabolite	Others
Petasitenine (Fukinotoxin) is a pyrrolizidine alkaloid that can be found in the plant Petasites japonicus, which is a carcinogenic metabolite of neopetasitenine. Petasitenine causes lactate dehydrogenase leakage, and exhibits hepatotoxicity .

HY-122367

Neoxaline	Bacterial	Neurological Disease
Neoxaline is an alkaloid produced by Aspergillus japonicus. Neoxaline does not possess antimicrobial activities, but weakly stimulates the central nervous system .

HY-N13108

8-Formylophiopogonone B	Others	Others
8-Formylophiopogonone B can be isolated from Ophiopogon japonicus,

HY-N9021

Isoleojaponin	Others	Others
Isoleojaponin is a Diterpenoids product that can be isolated from the herbs of Leonurus japonicus. .

HY-N3129

Oplopanon (-)-Oplopanone; 10α-Hydroxyoplopan-4-one	Others	Others
Oplopanon ((-)-Oplopanone) is a sesquiterpenic ketone that can be isolated from Oplopanax japonicus .

HY-N8938

Jasminoid A	Others	Others
Jasminoid A is a Sesquiterpenoids product that can be isolated from the herbs of Chloranthus japonicus .

HY-N3889

Excisanin B	Others	Others
Excisanin B is a Diterpenoids product that can be isolated from the herbs of Isodon japonicus .

HY-N7940

6-Aldehydoisoophiopogonone B	Others	Others
6-Aldehydoisoophiopogonone B (Compound 24) is a homoisoflavonoid that can be isolated from Ophiopogon japonicus .

HY-N9167

6α-Hydroxyhispanone	Others	Others
6α-Hydroxyhispanone is a Diterpenoids product that can be isolated from the aerial parts of Leonurus japonicus .

HY-N3131

Ophiopogonanone F	Others	Others
Ophiopogonanone F is a Flavonoids product that can be isolated from the tubers of Ophiopogon japonicus(Thunb) Ker-Gawl. .

HY-N8319

Leojaponin	Others	Others
Leojaponin (compound 2 ) is a labdane diterpene. Leojaponin can be isolated from the EtOH extract of the herb Leonurus japonicus* .*

HY-N1300

Shizukanolide F	Fungal	Infection Cancer
Shizukanolide F is a dimeric sesquiterpene, which is derivated from Chloranthus japonicus* Sieb. Shizukanolide F exhibits potent antifungal activities against various plant pathogenic fungi* and anti-metastasis breast cancer .

HY-N12131

Ejaponine A	Others	Metabolic Disease
Ejaponine A (Compound 1) is an insecticidal sesquiterpene ester. Ejaponine A is obtained from the natural Euonymus japonicus. Ejaponine A has Mythimna separata killing activity (LD₅₀89.2 μgg ^-1). Ejaponine A is used to kill Mythimna separata .

HY-N9188

3-(2,4-Dihydroxybenzyl)-5-hydroxy-7,8-dimethoxy-6-methylchroman-4-one	Others	Others
3-(2,4-Dihydroxybenzyl)-5-hydroxy-7,8-dimethoxy-6-methylchroman-4-one is a Flavonoids product that can be isolated from the fibrous root of Ophiopogon japonicus. .

HY-N11983

(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside	Others	Others
(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside (compound 1) is a steroidal saponin , can be isolated from the roots of Ophiopogon japonicus .

HY-N6061

Ophiopogonin C 1 Publications Verification	Others	Cancer
Ophiopogonin C, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin C shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 19.76 μM and 15.51 μM, respectively .

HY-N10876

8-epi-Chlorajapolide F	Others	Others
8-epi-Chlorajapolide F (compound 1) a sesquiterpene that can be isolated from the aboveground part of the Chloranthus japonicus. 8-epi-Chlorajapolide has few cytotoxic to human cancer cell lines NCI-H460 and SMMC-7721 (IC₅₀s>50 μg/mL) .

HY-N13177

25(S)Ruscogenin 3-O-α-L-rhamnopyranoside	Others	Inflammation/Immunology
25(S)Ruscogenin 3-O-α-L-rhamnopyranoside is from the fibrous roots of Ophiopogon japonicus and Liriope spicata var. prolifera. 25(S)Ruscogenin 3-O-α-L-rhamnopyranoside exhibits anti-inflammatory activity by inhibiting neutrophil responses to PMA (HY-18739), with an IC₅₀ value of 1.13 μM .

HY-N0914R

Ajugol (Standard)	Reference Standards Parasite Autophagy Interleukin Related Reactive Oxygen Species (ROS) mTOR	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Ajugol (Standard) is the analytical standard of Ajugol (HY-N0914). This product is intended for research and analytical applications. Ajugol is an orally active iridoid glycoside found in the traditional Chinese medicine Leonurus japonicus. Ajugol is an autophagy activator. Ajugol activates TFEB-mediated autophagy and lysosomal biogenesis. Ajugol also has anti-inflammatory effects. Ajugol has great potential in the research of asthma, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis .

HY-N19045

*Ophiopogon japonicus* extract**	Others	Others
Ophiopogon Japonicus Extract is obtained from the dried roots of the Liliaceae plant Ophiopogon japonicus. Its main active ingredient is Ophiopogon japonicus polysaccharides. It can be used in functional cosmetics, such as creams, lotions, lotions, essences, and masks.

HY-113038AR

α-Hydroxyglutaric acid disodium (Standard) 2-Hydroxyglutarate disodium (Standard); 2-Hydroxyglutaric acid disodium (Standard); 2-Hydroxypentanedioic acid disodium (Standard)	Reference Standards Histone Demethylase Endogenous Metabolite	Cancer
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

HY-E70100A

Acetyl xylan esterase, Cellvibrio japonicus	Biochemical Assay Reagents	Others
Acetyl xylan esterase, Cellvibrio japonicus (EC 3.1.1.72) is an enzyme that catalyzes a chemical reaction, the deacetylation of xylans and xylo-oligosaccharides. Acetyl xylan esterase, Cellvibrio japonicus (EC 3.1.1.72) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds.

HY-E70103J

exo-α-1,2-Arabinofuranosidase, Cellvibrio japonicus	Biochemical Assay Reagents	Others
exo-α-1,2-Arabinofuranosidase, Cellvibrio japonicus (EC.3.2.1.55) is a glycoside hydrolase .

HY-E70101B

α-Glucuronidase, Cellvibrio japonicus	Endogenous Metabolite	Metabolic Disease
α-Glucuronidase, Cellvibrio japonicus (EC 3.2.1.139), is a glycosidase that hydrolyzes O- and S-glycosides. Its two substrates are α-D-glucuronide and water, and its two products are an alcohol and D-glucuronic acid.

HY-E70119B

Pectate Lyase, Cellvibrio japonicus	Biochemical Assay Reagents	Metabolic Disease
Pectate Lyase, Cellvibrio japonicus (EC 4.2.2.2) is an enzyme involved in the maceration and soft rotting of plant tissue. Pectate lyase is responsible for the eliminative cleavage of pectate, yielding oligosaccharides with 4-deoxy-α-D-mann-4-enuronosyl groups at their non-reducing ends.

HY-E70897

Xylanase 10A, Cellvibrio japonicus	Biochemical Assay Reagents	Metabolic Disease
Xylanase 10A, Cellvibrio japonicus (EC 3.2.1.8) is the name given to a class of enzymes which degrade the linear polysaccharide beta-1,4-xylan into xylose, thus breaking down hemicellulose, one of the major components of plant cell walls.

HY-E71310

β-Mannanase 26A, Cellvibrio japonicus	Biochemical Assay Reagents	Others
β-Mannanase 26A, Cellvibrio japonicus (EC 3.2.1.78) is an enzyme with system name 4-beta-D-mannan mannanohydrolase. This enzyme catalyses the following chemical reaction: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

HY-N11078

Shizukaol G	Others	Others
Shizukaol G is a dimeric sesquiterpene. Shizukaol G can be isolated from the roots of Chloranthus japonicus .

HY-N19729

Chikusetsusaponin FK6	Others	Others
Chikusetsusaponin FK6 is a dammarane-type triterpenoid saponin that can be found in the fruits of Panax japonicus C. A. MEYER .

HY-N18256

Leonuriside B	Others	Metabolic Disease
Leonuriside B is a hepatoprotective glycoside. Leonuriside B can be found in Chinese motherwort (Leonurus japonicus Houtt). Leonuriside B can be used for the research of liver-related disorders .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703487

	*Ferritin Protein, Penaeus japonicus* (Q88R, His)** Ferritin; Penaeus japonicus; Kuruma prawn; Oxidoreductase; 1.16.3.1	Others	E. coli
	Ferritin Protein, Penaeus japonicus (Q88R, His) is the recombinant Ferritin, expressed by E. coli , with His labeled tag. ,

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