2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Bakkenolide D

Bakkenolide D is a sesquiterpene lactone. Bakkenolide D is the major component of Bakkenolides in Petasites tricholobus. Bakkenolide D exhibits anti-allergic and antihistamine activities, and can be used in studies related to allergic rhinitis.

For research use only. We do not sell to patients.

Bakkenolide D

Bakkenolide D Chemical Structure

CAS No. : 18456-03-6

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Bakkenolide D Related Antibodies

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Description

Bakkenolide D is a sesquiterpene lactone. Bakkenolide D is the major component of Bakkenolides in Petasites tricholobus. Bakkenolide D exhibits anti-allergic and antihistamine activities, and can be used in studies related to allergic rhinitis[1][2].

Parmacokinetics
Species Dose Route Cmax Tmax T1/2 AUC0-24 AUCinf CL/F Vz/F MRT Bioavailability
Rat[2] 10 mg/kg p.o. 10.1 ng/mL 15 min 11.8 h 72.1 ng·h/mL 98.3 ng·h/mL 105.2 L/h/kg 1753.3 L/kg 8.14 h 2.57 %
Rat[2] 1 mg/kg i.v. 191 ng/mL 5 min 8.79 h 281 ng·h/mL 309 ng·h/mL 3.67 L/h/kg 47.1 L/kg 5.17 h /
In Vivo

Bakkenolide D exhibits low oral bioavailability in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

408.51

Formula

C21H28O6S
CAS No.
SMILES

O=C(O[C@@H]1[C@]2([H])[C@@H](OC(C)=O)[C@]3(C[C@]2(C)[C@@H](C)CC1)C(OCC3=C)=O)/C=C\SC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Bakkenolide D Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bakkenolide D18456-03-6Histamine Receptorspiro-β-methylene-γ-lactone moietyPetasites tricholobusPetasites japonicusanti-histamine agentcis-hydrindane skeletonPetasites tatewakianussesquiterpene lactonePetasites formosanusInhibitorinhibitorinhibit

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