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specific+substrate

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48

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8

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1

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31

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2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134452
    MeAIB
    4 Publications Verification

    α-(Methylamino)isobutyric acid

    		 Amino acid Transporter Cancer
    MeAIB (α-(Methylamino)isobutyric acid) is a specific?substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na +-dependent manner .
    MeAIB
  • HY-137875
    Hippuryl-His-Leu-OH hydrate

    N-Benzoyl-Gly-His-Leu hydrate

    		 Angiotensin-converting Enzyme (ACE) Amino Acid Derivatives Cardiovascular Disease
    Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) hydrate is a specific substrate for angiotensin-converting enzyme ACE I and is a molecular tool used for ACE activity detection in in vitro experiments. Hippuryl-His-Leu-OH hydrate is hydrolyzed by ACE through competitive binding. Under ACE catalysis, Hippuryl-His-Leu-OH hydrate undergoes hydrolysis to produce hippuric acid (HA). The amount of HA produced can be used to quantitatively assess ACE activity or screen for ACE inhibitors. The His-Leu released from Hippuryl-His-Leu-OH hydrate can also react with o-phthalaldehyde or Fluorescamine (HY-D0715) for fluorescence detection. Hippuryl-His-Leu-OH hydrate can be applied to the in vitro screening of ACE inhibitors for hypertension and cardiovascular diseases, and is also used in the study of changes in ACE activity during physiological and pathological processes such as renal compensatory hypertrophy .
    Hippuryl-His-Leu-OH hydrate
  • HY-W010991
    N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly
    1 Publications Verification

    FAPGG

    		 Angiotensin-converting Enzyme (ACE) Others
    N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10 -4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system .
    N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly
  • HY-164899
    2A3

    2-aminopyridine-3-carboxylic acid imidazolide

    		 Transmembrane Glycoprotein Cancer
    2A3 (2-aminopyridine-3-carboxylic acid imidazolide) is a T cell activator that specifically binds to CEACAM6 and CEACAM5. 2A3 exhibits enzymatic activity that catalyzes the glucuronidation of specific substrates (e.g., 1-naphthol), and possesses significant cytotoxic activity. When integrated into CAR T cells or used alone, 2A3 acts by inducing cytokine release, degranulation, and direct cytotoxicity. 2A3 kills pancreatic and breast cancer cells with high target antigen expression in vitro, and significantly inhibits the growth of pancreatic cancer xenografts in vivo. 2A3 broadly targets malignant tumors with overexpressed CEACAM5, CEACAM6, or co-expressed both, and shows high expression mainly in tissues such as the liver and colon. 2A3 serves as an important research tool for the immunotherapy of pancreatic and breast cancer . 2A3 is a novel SHAPE reagent, which can be used for the analysis of RNA structure both in vitro and in vivo . 2A3 is an electrophilic chemical probe that acylates the 2'-OH in the RNA backbone. 2A3 can be used for RNA SHAPE-MaP experiments and is capable of analyzing the RNA secondary structures at single nucleotide resolution.
    2A3
  • HY-145983
    Suc-Gly-Pro-AMC
    1 Publications Verification

    		 FAP Prolyl Endopeptidase (PREP) Cancer
    Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research .
    Suc-Gly-Pro-AMC
  • HY-P0248
    Kemptide
    1 Publications Verification

    		 PKA Metabolic Disease
    Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA).
    Kemptide
  • HY-N6839
    1,4-b-D-Xylopentaose

    		Glycosidase Others
    1,4-b-D-Xylopentaose is a linear pentasaccharide composed of 5 β-D-xylose units linked via 1,4-glycosidic bonds, and serves as a specific substrate for barley α-L-arabinofuranosidase .
    1,4-b-D-Xylopentaose
  • HY-137841
    L-Arginine-7-amido-4-methylcoumarin hydrochloride

    Arginine 4-methyl-7-coumarylamide hydrochloride

    		 Cathepsin Others
    L-Arginine-7-amido-4-methylcoumarin (Arginine 4-methyl-7-coumarylamide) hydrochloride is a specific substrate of cathepsin H but not for cathepsins L and B .
    L-Arginine-7-amido-4-methylcoumarin hydrochloride
  • HY-P2752
    Lipoprotein lipase, Pseudomonas sp

    LPL

    		 Endogenous Metabolite Metabolic Disease Cancer
    Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .
    Lipoprotein lipase, Pseudomonas sp
  • HY-118155
    9-Amino-6-chloro-2-methoxyacridine
    2 Publications Verification

    ACMA

    		 Fluorescent Dye Others
    9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H +/solute antiport system .
    9-Amino-6-chloro-2-methoxyacridine
  • HY-160289
    ARI-3144

    		FAP Cancer
    ARI-3144 is an excellent and specific substrate for fibroblast activation protein (FAP). ARI-3144 is usually coupled with the fluorophore 7-Amino-4-methylcoumarin (HY-D0027) (AMC) for detection and quantification of FAP .
    ARI-3144
  • HY-W141916
    Pentaglycine

    Tetraglycylglycine; Gly-Gly-Gly-Gly-Gly; NSC 96353

    		 Amino Acid Derivatives Bacterial Infection
    Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection .
    Pentaglycine
  • HY-P0136
    SAMS
    2 Publications Verification

    		 AMPK Metabolic Disease
    SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
    SAMS
  • HY-P0266
    N-Acetyl-Ser-dAsp-Lys-Pro

    Ac-SdKP

    		 Angiotensin-converting Enzyme (ACE) Cardiovascular Disease Inflammation/Immunology
    N-Acetyl-Ser-dAsp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.
    N-Acetyl-Ser-dAsp-Lys-Pro
  • HY-P10602
    PKA Regulatory Subunit II Substrate

    RII phosphopeptide

    		 PKA Others
    PKA Regulatory Subunit II Substrate (RII phosphopeptide) is a tool peptide derived from the regulatory subunit Type II (RII) of cyclic AMP-dependent protein kinase (PKA). PKA Regulatory Subunit II Substrate is commonly used to mimic the phosphorylation of protein kinases and as a specific substrate for protein phosphatases to assess the activities of these enzymes .
    PKA Regulatory Subunit II Substrate
  • HY-111956B
    D-Ala-Lys-AMCA hydrochloride
    1 Publications Verification

    		 Fluorescent Dye Cancer
    D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm) .
    D-Ala-Lys-AMCA hydrochloride
  • HY-P4310
    Boc-Val-Leu-Lys-AMC

    		Ser/Thr Protease Others
    Boc-Val-Leu-Lys-AMC is a sensitive, fluorogenic, and specific substrate of plasmin, as well as acrosin from the ascidian Halocynthia roretzi, porcine calpain isozymes I and II, and papain .
    Boc-Val-Leu-Lys-AMC
  • HY-P2016
    Ac-Nle-Pro-Nle-Asp-AMC

    		Proteasome Others
    Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
    Ac-Nle-Pro-Nle-Asp-AMC
  • HY-W353804
    2′-Deoxy-β-L-uridine

    		Nucleoside Antimetabolite/Analog Infection
    2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase .
    2′-Deoxy-β-L-uridine
  • HY-P1597
    Malantide
    1 Publications Verification

    		 PKA PKC Cancer
    Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a Km of 16 μM .
    Malantide
  • HY-P0136AF
    FAM-SAMS TFA

    		Fluorescent Dye Others
    FAM-SAMS TFA is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .
    FAM-SAMS TFA
  • HY-D1523
    Z-Arg-Arg-4MβNA triacetate

    		Cathepsin Others
    Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λex = 355 nm, λem = 430 nm) .
    Z-Arg-Arg-4MβNA triacetate
  • HY-P3818
    PKCδ Peptide Substrate

    		PKC Others
    PKCδ Peptide Substrate is an absolutely specific substrate for the δ-type of PKC, with a sequence corresponding to sequence 422-443 of murine eEF-1α and containing Thr-431 .
    PKCδ Peptide Substrate
  • HY-111956
    D-Ala-Lys-AMCA

    		Fluorescent Dye Cancer
    D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm) .
    D-Ala-Lys-AMCA
  • HY-141427
    MOCPAC

    		HDAC Cancer
    MOCPAC is an HDAC1 specific substrate .
    MOCPAC
  • HY-P3743
    p60c-src Substrate

    		Src Others Others
    p60c-src Substrate is an efficient and specific substrate for p60c-src protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .
    p60c-src Substrate
  • HY-P0266B
    N-Acetyl-Ser-dAsp-Lys-Pro acetate

    Ac-SdKP acetate

    		 Angiotensin-converting Enzyme (ACE) Inflammation/Immunology
    N-Acetyl-Ser-dAsp-Lys-Pro (Ac-SdKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-dAsp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties .
    N-Acetyl-Ser-dAsp-Lys-Pro acetate
  • HY-P4551
    Hippuryl-His-Leu-OH

    N-Benzoyl-Gly-His-Leu

    		 Angiotensin-converting Enzyme (ACE) Amino Acid Derivatives Cardiovascular Disease
    Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) is a specific substrate for angiotensin-converting enzyme (ACE I) and a molecular tool used for ACE activity detection in in vitro experiments. Hippuryl-His-Leu-OH is hydrolyzed by ACE through competitive binding. Under ACE catalysis, Hippuryl-His-Leu-OH undergoes hydrolysis to produce hippuric acid (HA). The amount of HA produced can be used to quantitatively assess ACE activity or screen for ACE inhibitors. The released His-Leu can also react with o-phthalaldehyde or Fluorescamine (HY-D0715) for fluorescence detection. Hippuryl-His-Leu-OH can be applied to the in vitro screening of ACE inhibitors for hypertension and cardiovascular diseases, and is also used in the study of ACE activity changes in physiological and pathological processes such as renal compensatory hypertrophy .
    Hippuryl-His-Leu-OH
  • HY-148614
    Isocaproaldehyde

    4-Methylpentanal; 4-Methylvaleraldehyde

    		 Others Metabolic Disease
    Isocaproaldehyde is a product of side-chain cleavage of cholesterol. Isocaproaldehyde is an endogenous specific substrate of mouse vas deferens protein (MVDP) .
    Isocaproaldehyde
  • HY-P0266A
    N-Acetyl-Ser-dAsp-Lys-Pro TFA

    Ac-SdKP TFA

    		 Angiotensin-converting Enzyme (ACE) Cardiovascular Disease Inflammation/Immunology
    N-Acetyl-Ser-dAsp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.
    N-Acetyl-Ser-dAsp-Lys-Pro TFA
  • HY-P4524
    FA-Phe-Phe

    		Angiotensin-converting Enzyme (ACE) Others
    FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A .
    FA-Phe-Phe
  • HY-D0144
    Resorufin methyl ether

    Methoxyresorufin

    		 Cytochrome P450 Others
    Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate . Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents .
    Resorufin methyl ether
  • HY-W747907
    4-Pyridoxolactone

    β-Pyracin

    		 Endogenous Metabolite Others
    4-Pyridoxolactone (β-Pyracin) is a critical substrate in vitamin B6 degradation pathway I, primarily involved in the vitamin B6 metabolic process mediated by soil microorganisms. 4-Pyridoxolactone serves as the specific substrate for 4-pyridoxolactonase, undergoing a zinc-dependent lactone-ring hydrolysis reaction catalyzed by this enzyme to generate 4-pyridoxic acid (4PA) .
    4-Pyridoxolactone
  • HY-P10316
    CaMKI(299-320)

    Calmodulin-Dependent Protein Kinase I (299-320) Binding Domain

    		 CaMK Others
    CaMKI (299-320) refers to a peptide consisting of residues 299-320 of Calcium/calmodulin-dependent protein kinase I (CaMKI). CaMKI (299-320), as a protein kinase, has a high affinity interaction with Ca 2+-CAM (Kd≤1 nM≤1 nM), which can phosphorylate specific substrate proteins, thereby regulating their activity. CaMKI (299-320) contains the CAM-binding domain and the self-inhibition domain, and CaMKI (299-320) can be used to study cell physiological processes, including cell proliferation, differentiation, and apoptosis .
    CaMKI(299-320)
  • HY-177787A
    2'-Deoxy-N-methyl-AMP ammonium

    		Nucleoside Antimetabolite/Analog Others
    2'-Deoxy-N-methyl-AMP ammonium is an N6-substituted adenine nucleotide derivative and a glycosyl donor. On one hand, 2'-Deoxy-N-methyl-AMP ammonium acts as a specific substrate for N6-methyl-AMP aminohydrolase, and it is catalytically converted to dIMP to participate in the nucleotide metabolic cycle. On the other hand, 2'-Deoxy-N-methyl-AMP ammonium also serves as a guanosine diphosphate (GDP)-linked fucose derivative donor, driving site-specific glycoconjugation of proteins under the mediation of α-1,3-fucosyltransferase. 2'-Deoxy-N-methyl-AMP ammonium is an important molecular tool for investigating the mechanisms of nucleotide modification and protein glycosylation .
    2'-Deoxy-N-methyl-AMP ammonium
  • HY-148415
    Ac-Phe-Gly-pNA

    		Ser/Thr Protease Others
    Ac-Phe-Gly-pNA is the chymotrypsin specific substrate .
    Ac-Phe-Gly-pNA
  • HY-P1347
    RETF-4NA

    		Biochemical Assay Reagents Metabolic Disease
    RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α2M .
    RETF-4NA
  • HY-P0136F
    FAM-SAMS

    		AMPK Others
    FAM-SAMS is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .
    FAM-SAMS
  • HY-P10073
    Calpain-1 substrate, fluorogenic

    		Fluorescent Dye Others
    Calpain-1 substrate, fluorogenic serves as a sensitive and specific substrate for calpain-1 that cleaves Tyr-Gly bond and results in enhanced fluorescence .(Ex/Em = 490 nm/518 nm)
    Calpain-1 substrate, fluorogenic
  • HY-P3764
    Protein kinase C substrate

    		PKC Others
    Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. Protein kinase C is a key regulatory element in signal transduction and exerts its effects by catalysing specific substrate phosphorylation .
    Protein kinase C substrate
  • HY-P10527
    CSK substrate

    		Src Others
    CSK substrate is a specific substrate for C-terminal Src kinase (CSK), which binds CSK and downregulates the Src family members. CSK substrate preferentially phosphorylates certain amino acid residues that are distinct from the conserved Src C-terminal sequence .
    CSK substrate
  • HY-134452R
    MeAIB (Standard)

    α-(Methylamino)isobutyric acid (Standard)

    		 Amino acid Transporter Reference Standards Cancer
    MeAIB (Standard) is the analytical standard of MeAIB. This product is intended for research and analytical applications. MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner .
    MeAIB (Standard)
  • HY-W194107
    Antitumor agent-152

    		DNA/RNA Synthesis Cancer
    Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of 3H-dC in L1210 leukemia cells with an IC50 value of 1.12 μM .
    Antitumor agent-152
  • HY-P1597A
    Malantide TFA

    		PKA PKC Cancer
    Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM .
    Malantide TFA
  • HY-126785
    Suc-AAP-Abu-pNA

    Colorimetric Elastase Substrate

    		 Elastase Others
    Suc-AAP-Abu-pNA (Colorimetric Elastase Substrate) is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s -1 M -1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,000 s -1 M -1 for porcine pancreatic elastase). Suc-AAP-Abu-pNA also promotes OPC migration .
    Suc-AAP-Abu-pNA
  • HY-111956A
    D-Ala-Lys-AMCA TFA

    		Fluorescent Dye Cancer
    D-Ala-Lys-AMCA TFA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA TFA can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm) .
    D-Ala-Lys-AMCA TFA
  • HY-P11641
    GCRRGPLGLSLGKRRCG

    		MMP Inflammation/Immunology
    GCRRGPLGLSLGKRRCG is an MMP13-specific substrate peptide cleaved by MMP13. GCRRGPLGLSLGKRRCG contributes to an MMP13-responsive hydrogel microsphere system that achieves intelligent and controllable drug release in osteoarthritis (OA), decelerates disease progression, and promotes articular cartilage repair. GCRRGPLGLSLGKRRCG can be used for the research of osteoarthritis .
    GCRRGPLGLSLGKRRCG
  • HY-W612175
    H-Ala-pNA

    		Leukotriene Receptor Others
    H-Ala-pNA is an L-amino acid p-nitroaniline (pNA) derivative and a specific substrate for leukotriene A4 hydrolase. The D-enantiomer of H-Ala-pNA shows no activity toward leukotriene A4 hydrolase. H-Ala-pNA can be catalytically hydrolyzed by leukotriene A4 hydrolase, and the p-nitroaniline produced during the reaction is monitored spectrophotometrically at 405 nm to enable quantitative detection of enzyme activity. H-Ala-pNA is used to evaluate the potency of inhibitors targeting the amidase activity of leukotriene A4 hydrolase .
    H-Ala-pNA

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