1. Epigenetics PI3K/Akt/mTOR
  2. AMPK
  3. SAMS

SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

For research use only. We do not sell to patients.

SAMS Chemical Structure

SAMS Chemical Structure

CAS No. : 125911-68-4

Size Price Stock Quantity
1 mg USD 96 In-stock
5 mg USD 384 In-stock
10 mg USD 672 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

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Description

SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

IC50 & Target[1]

AMPK

 

In Vitro

SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).The SAMS peptide is not phosphorylated by any of five other purified protein kinases tested[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1779.15

Formula

C74H131N29O18S2

CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence

His-Met-Arg-Ser-Ala-Met-Ser-Gly-Leu-His-Leu-Val-Lys-Arg-Arg

Sequence Shortening

HMRSAMSGLHLVKRR

SMILES

N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(C)C)NC(CNC([C@H](CO)NC([C@H](CCSC)NC([C@H](C)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CCSC)NC([C@@H](N)CC1=CN=CN1)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (56.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5621 mL 2.8103 mL 5.6207 mL
5 mM 0.1124 mL 0.5621 mL 1.1241 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (56.21 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5621 mL 2.8103 mL 5.6207 mL 14.0517 mL
5 mM 0.1124 mL 0.5621 mL 1.1241 mL 2.8103 mL
10 mM 0.0562 mL 0.2810 mL 0.5621 mL 1.4052 mL
15 mM 0.0375 mL 0.1874 mL 0.3747 mL 0.9368 mL
20 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7026 mL
25 mM 0.0225 mL 0.1124 mL 0.2248 mL 0.5621 mL
30 mM 0.0187 mL 0.0937 mL 0.1874 mL 0.4684 mL
40 mM 0.0141 mL 0.0703 mL 0.1405 mL 0.3513 mL
50 mM 0.0112 mL 0.0562 mL 0.1124 mL 0.2810 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SAMS
Cat. No.:
HY-P0136
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