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  4. 9-Amino-6-chloro-2-methoxyacridine

9-Amino-6-chloro-2-methoxyacridine  (Synonyms: ACMA)

製品番号: HY-118155 純度: 99.88%
COA 取扱説明書 Technical Support

9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system.

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9-Amino-6-chloro-2-methoxyacridine

9-Amino-6-chloro-2-methoxyacridine 構造式

CAS 番号 : 3548-09-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 77 在庫あり
Solution
10 mM * 1 mL in DMSO USD 77 在庫あり
Solid
5 mg $70 在庫あり
10 mg $120 在庫あり
25 mg $245 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

9-Amino-6-chloro-2-methoxyacridine 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

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製品説明

9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system[1].

Cellular Effect
Cell Line Type Value Description References
HT-22 EC50
7.41 μM
Compound: 46
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
[PMID: 24602904]
Panel NCI-60 (60 carcinoma cell lines) GI50
1 μM
Compound: 8
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
[PMID: 34731767]
Panel NCI-60 cells GI50
1 μM
Compound: 8
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
[PMID: 34731767]
ScN2a EC50
0.13 μM
Compound: 19
Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
[PMID: 18556207]
T98G GI50
0.6 μM
Compound: 8
Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 34731767]
分子量

258.70

分子式

C14H11ClN2O
CAS 番号
Appearance

Solid

Color

Light yellow to green yellow

SMILES

ClC1=CC=C2C(N=C3C=CC(OC)=CC3=C2N)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 25 mg/mL (96.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8655 mL 19.3274 mL 38.6548 mL
5 mM 0.7731 mL 3.8655 mL 7.7310 mL
10 mM 0.3865 mL 1.9327 mL 3.8655 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.88%

COA (247 KB) HNMR (250 KB) RP-HPLC (221 KB) MS (69 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8655 mL 19.3274 mL 38.6548 mL 96.6370 mL
5 mM 0.7731 mL 3.8655 mL 7.7310 mL 19.3274 mL
10 mM 0.3865 mL 1.9327 mL 3.8655 mL 9.6637 mL
15 mM 0.2577 mL 1.2885 mL 2.5770 mL 6.4425 mL
20 mM 0.1933 mL 0.9664 mL 1.9327 mL 4.8319 mL
25 mM 0.1546 mL 0.7731 mL 1.5462 mL 3.8655 mL
30 mM 0.1288 mL 0.6442 mL 1.2885 mL 3.2212 mL
40 mM 0.0966 mL 0.4832 mL 0.9664 mL 2.4159 mL
50 mM 0.0773 mL 0.3865 mL 0.7731 mL 1.9327 mL
60 mM 0.0644 mL 0.3221 mL 0.6442 mL 1.6106 mL
80 mM 0.0483 mL 0.2416 mL 0.4832 mL 1.2080 mL
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9-Amino-6-chloro-2-methoxyacridine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9-Amino-6-chloro-2-methoxyacridine3548-09-2ACMAFluorescent DyepH sensitive fluorescent probesubstrateH+/solute antiport systemInhibitorinhibitorinhibit

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製品名:
9-Amino-6-chloro-2-methoxyacridine
製品番号:
HY-118155
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