9-Amino-6-chloro-2-methoxyacridine
Based on 3 publication(s) in Google Scholar
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 3548-09-2
- Formula: C14H11ClN2O
- Molecular Weight:258.70
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 9-Amino-6-chloro-2-methoxyacridine
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-22 | EC50 |
7.41 μM
Compound: 46
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Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
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[PMID: 24602904] |
| Panel NCI-60 (60 carcinoma cell lines) | GI50 |
1 μM
Compound: 8
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Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
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[PMID: 34731767] |
| Panel NCI-60 cells | GI50 |
1 μM
Compound: 8
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Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
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[PMID: 34731767] |
| ScN2a | EC50 |
0.13 μM
Compound: 19
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Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
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[PMID: 18556207] |
| T98G | GI50 |
0.6 μM
Compound: 8
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Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 34731767] |
Chemical Information
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CAS No. 3548-09-2
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Appearance Solid
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Molecular Weight 258.70
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Formula C14H11ClN2O
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Color Light yellow to green yellow
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SMILES
ClC1=CC=C2C(N=C3C=CC(OC)=CC3=C2N)=C1
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Synonyms
ACMA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (3)
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Journal Impact Factor
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Most Recent
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J Cell Biol
2025 Oct 6;224(10):e202503166. PMID: 40923996 -
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Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (96.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8655 mL | 19.3274 mL | 38.6548 mL | 96.6370 mL |
| 5 mM | 0.7731 mL | 3.8655 mL | 7.7310 mL | 19.3274 mL | |
| 10 mM | 0.3865 mL | 1.9327 mL | 3.8655 mL | 9.6637 mL | |
| 15 mM | 0.2577 mL | 1.2885 mL | 2.5770 mL | 6.4425 mL | |
| 20 mM | 0.1933 mL | 0.9664 mL | 1.9327 mL | 4.8319 mL | |
| 25 mM | 0.1546 mL | 0.7731 mL | 1.5462 mL | 3.8655 mL | |
| 30 mM | 0.1288 mL | 0.6442 mL | 1.2885 mL | 3.2212 mL | |
| 40 mM | 0.0966 mL | 0.4832 mL | 0.9664 mL | 2.4159 mL | |
| 50 mM | 0.0773 mL | 0.3865 mL | 0.7731 mL | 1.9327 mL | |
| 60 mM | 0.0644 mL | 0.3221 mL | 0.6442 mL | 1.6106 mL | |
| 80 mM | 0.0483 mL | 0.2416 mL | 0.4832 mL | 1.2080 mL |
9-Amino-6-chloro-2-methoxyacridine Related Classifications
HY-118155 Related Classifications
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