2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Cytochrome P450 P2Y Receptor
  4. Clopidogrel hydrogen sulfate

Clopidogrel hydrogen sulfate  (Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate)

Cat. No.: HY-17459 Pureza: 99.88%
COA
SDS
Instrucciones de manejo Technical Support

Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.

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No. CAS : 120202-66-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
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500 mg En stock
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Revisión del cliente

Based on 30 publication(s) in Google Scholar

Other Forms of Clopidogrel hydrogen sulfate:

Clopidogrel hydrogen sulfate Related Antibodies

Top Publications Citing Use of Products

30 Publications Citing Use of MCE Clopidogrel hydrogen sulfate

Cell Imaging/Staining
Histological Imaging/Staining
RT-PCR
WB
In Vivo Efficacy Study

    Clopidogrel hydrogen sulfate purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Dec 8.  [Abstract]

    In vehicle-treated retinas, microglial processes rapidly converged toward the injury site within 30 min. This response was markedly suppressed by Clopidogrel (10 mg/kg, i.p.) treatment.

    Clopidogrel hydrogen sulfate purchased from MedChemExpress. Usage Cited in: Am J Transl Res. 2020 May 15;12(5):1741-1753.  [Abstract]

    Expression of MKP-5 and phosphorylated p38/MAPK in Clopidogrel-treated gastric mucosal tissues and cells. Western blot analysis show MKP-5 is decreased and negatively correlated of Clopidogrel.

    Clopidogrel hydrogen sulfate purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2019 Jan 1;15(1):239-252.  [Abstract]

    Representative images of kidney tissue H&E (upper panel) and Sirius red staining (lower panel) of control (Ctl) and diabetic mice (DM) with or without Clopidogrel (20 mg/kg, p.o.) treatment (Ctl + Clo & DM + Clo).

    Clopidogrel hydrogen sulfate purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2019 Jan 1;15(1):239-252.  [Abstract]

    RT-PCR analysis of the T1D kidney tissue showed significantly elevated mRNA levels of ECM molecules, such as FN and collagen I, which were reduced by the Clopidogrel (20 mg/kg, p.o.) treatment.

    Clopidogrel hydrogen sulfate purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2019 Jan 1;15(1):239-252.  [Abstract]

    Western blot analysis confirmed that the T1D-induced increase in the FN expression at six months was decreased by the Clopidogrel (20 mg/kg, p.o.) treatment.

    Clopidogrel hydrogen sulfate purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2019 Jan 1;15(1):239-252.  [Abstract]

    The Clopidogrel (20 mg/kg, p.o.) treatment did not affect the body weight, however, it significantly decreased the blood glucose.

    Ver todos los productos específicos de isoformas Cytochrome P450:

    Ver todas las isoformas
    CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

    Ver todos los productos específicos de isoformas P2Y Receptor:

    Ver todas las isoformas
    P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

    • Actividad biológica

    • Pureza y Documentación

    • Referencias

    • Revisión del cliente

    Descripciòn

    Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2]．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[5].

    IC50 & Target[1]

    CYP2B6

    18.2 nM (IC50)

    P2Y12 Receptor

     

    CYP2C19

    524 nM (IC50)

    In Vitro

    Clopidogrel (1.5 mM;12 and 24 hours) up-regulates the expression of TRIB3 and CHOP in a concentration- and time-dependent manner, as measured by real-time PCR and Western blot analysis[3].
    Clopidogrel (1.5 mM; 24 hours) significantly induces human gastric epithelial cell (GES-1) apoptosis[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clopidogrel hydrogen sulfate Related Antibodies

    Western Blot Analysis[3]

    Cell Line: GES-1 cells
    Concentration: 1.5 mM
    Incubation Time: 12 and 24 hours
    Result: The mRNA expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.
    The protein expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.

    Apoptosis Analysis[3]

    Cell Line: Gastric epithelial cell (GES-1) cells
    Concentration: 1.5 mM
    Incubation Time: 24 hours
    Result: Induced apoptosis of gastric epithelial cells．
    In Vivo

    Clopidogrel (5 mg/kg) significantly inhibits thrombus formation compared with vehicle. Acetylsalicylic acid (0.15 mg/kg) can add to the antithrombotic effect of Clopidogrel in mice; Acetylsalicylic acid (0.6 mg/kg) blunts the antithrombotic effect of Clopidogrel[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Age-matched C57BL/6J male mice weighing at least 25 g were used at 8 to 12 weeks of age[4]
    Dosage: 5 mg/kg
    Administration: Gavage treatment
    Result: Clopidogrel significantly inhibited thrombus formation compared with vehicle.
    When Clopidogrel was given in combination with 0.6 mg/kg ASA, thrombi were significantly larger than those measured with Clopidogrel alone.
    In contrast, when Clopidogrel was given in combination with 0.15 mg/kg ASA , thrombi were significantly smaller than those in mice treated with Clopidogrel and 0.6 mg/kg ASA, and smaller than those in mice given Clopidogrel alone.
    Peso molecular

    419.90

    Fòrmula

    C16H18ClNO6S2
    No. CAS
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    ClC1=C([C@@H](C(OC)=O)N2CCC3=C(C=CS3)C2)C=CC=C1.O=S(O)(O)=O
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvente y solubilidad
    In Vitro: 

    DMSO : 200 mg/mL (476.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 16.67 mg/mL (39.70 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3815 mL 11.9076 mL 23.8152 mL
    5 mM 0.4763 mL 2.3815 mL 4.7630 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 5 mg/mL (11.91 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 5 mg/mL (11.91 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (119.08 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureza y Documentación

    Purity: 99.88%

    SDS (620 KB)

    COA (257 KB) HNMR (284 KB) LCMS (87 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.3815 mL 11.9076 mL 23.8152 mL 59.5380 mL
    5 mM 0.4763 mL 2.3815 mL 4.7630 mL 11.9076 mL
    10 mM 0.2382 mL 1.1908 mL 2.3815 mL 5.9538 mL
    15 mM 0.1588 mL 0.7938 mL 1.5877 mL 3.9692 mL
    20 mM 0.1191 mL 0.5954 mL 1.1908 mL 2.9769 mL
    25 mM 0.0953 mL 0.4763 mL 0.9526 mL 2.3815 mL
    30 mM 0.0794 mL 0.3969 mL 0.7938 mL 1.9846 mL
    DMSO 40 mM 0.0595 mL 0.2977 mL 0.5954 mL 1.4884 mL
    50 mM 0.0476 mL 0.2382 mL 0.4763 mL 1.1908 mL
    60 mM 0.0397 mL 0.1985 mL 0.3969 mL 0.9923 mL
    80 mM 0.0298 mL 0.1488 mL 0.2977 mL 0.7442 mL
    100 mM 0.0238 mL 0.1191 mL 0.2382 mL 0.5954 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Clopidogrel hydrogen sulfate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Clopidogrel hydrogen120202-66-6(S)-(+)-Clopidogrel bisulfate(S)-(+)-Clopidogrel hydrogenCytochrome P450P2Y ReceptorCYPsAntiplateletbloodclotCYP2B6CYP2C19antithromboticplateletaggregationInhibitorinhibitorinhibit

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    Nombre del producto:
    Clopidogrel hydrogen sulfate
    Cat. No.:
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