2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Dopamine Receptor 5-HT Receptor Potassium Channel
  4. SCH-23390 hydrochloride

SCH-23390 (hydrochloride)  (Synonyms: R-(+)-SCH-23390 hydrochloride; SCH23390塩酸塩)

製品番号: HY-19545A 純度: 99.83% ee.: 100.00%
COA 取扱説明書 Technical Support

SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.

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CAS 番号 : 125941-87-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 101 在庫あり
Solution
10 mM * 1 mL in DMSO USD 101 在庫あり
Solid
1 mg $43 在庫あり
5 mg $92 在庫あり
10 mg $125 在庫あり
25 mg $277 在庫あり
50 mg $515 在庫あり
100 mg $937 在庫あり
200 mg   お問い合わせ  
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カスタマーレビュー

Based on 31 publication(s) in Google Scholar

Other Forms of SCH-23390 hydrochloride:

SCH-23390 (hydrochloride) 関連抗体

Top Publications Citing Use of Products

顧客検証

Bio/Physico-chemical Assay
In Vivo Efficacy Study
IP
WB
IF

    SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590.  [Abstract]

    SCH23390 (10 μM, 2 h) decreased the association between Sig1R and BiP by Co-IP.

    SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590.  [Abstract]

    We detected increased translocation of Sig1R to plasma membrane in SH-SY5Y cells treated with SCH23390 (10 μM, 2 h).

    SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590.  [Abstract]

    Primary neurons from WT and Sig1R KO mice were pre-treated with SCH23390 (10 μM) or SKF10047 (0.5 or 5 μM) for 30 min prior to and during treatment with MPP+ (800 μM). After incubation for 24 h, cells were fixed and subjected to immunostaining with an anti-MAP2 antibody (1:2000) as described, followed by double-staining with TUNEL (red) and Hoechst (blue). SCH23390 synergistically promotes the neuroprotective effect of the Sig1R agonist, SKF10047.

    SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941.   [Abstract]

    GSH levels in astrocytes treated with 10 μM cabergoline for 12 h after pretreatment with SCH23390 (10 μM) or sulpiride (10 μM).

    SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120.  [Abstract]

    SCH23390 (0.05, 0.1, 0.2 μg/mouse) induced decreased social behavior in C57BL/6J mice.

    Dopamine Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

    5-HT Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

    • 生物活性

    • プロトコル

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM[1][2][3].

    IC50 & Target[1][2][3]

    5-HT1C Receptor

     

    5-HT2C Receptor

     

    D1 Receptor

    0.2 nM (Ki)

    D5 Receptor

    0.3 nM (Ki)

    5-HT2C Receptor

    9.3 nM (Ki)

    GIRK

    268 nM (IC50)

    体外実験

    SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SCH-23390 (hydrochloride) 関連抗体
    体内実験

    SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents, nonhuman primates, and humans[1].
    SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1].
    SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    324.24

    分子式

    C17H19Cl2NO
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1.[H]Cl
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 100 mg/mL (308.41 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 100 mg/mL (308.41 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0841 mL 15.4207 mL 30.8414 mL
    5 mM 0.6168 mL 3.0841 mL 6.1683 mL
    10 mM 0.3084 mL 1.5421 mL 3.0841 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.83% ee.: 100.00%

    COA (257 KB) HNMR (251 KB) RP-HPLC (256 KB) NP-HPLC (329 KB) LCMS (108 KB) Elemental Analysis Report (115 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [5]

    Rats: All rats receive acclimatization saline injections the two afternoons 1 prior to 2 their test day. At the end of the Training phase, rats (n=15 or 16 rats/group) are assigned to one 3 of three conditions (0, 1, or 10 μg/kg IP injections of SCH 23390). The day following the Training phase, rats are tested in the operant 6 conditioning chambers for saccharin cue-reactivity (saccharin seeking)[5].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.0841 mL 15.4207 mL 30.8414 mL 77.1034 mL
    5 mM 0.6168 mL 3.0841 mL 6.1683 mL 15.4207 mL
    10 mM 0.3084 mL 1.5421 mL 3.0841 mL 7.7103 mL
    15 mM 0.2056 mL 1.0280 mL 2.0561 mL 5.1402 mL
    20 mM 0.1542 mL 0.7710 mL 1.5421 mL 3.8552 mL
    25 mM 0.1234 mL 0.6168 mL 1.2337 mL 3.0841 mL
    30 mM 0.1028 mL 0.5140 mL 1.0280 mL 2.5701 mL
    40 mM 0.0771 mL 0.3855 mL 0.7710 mL 1.9276 mL
    50 mM 0.0617 mL 0.3084 mL 0.6168 mL 1.5421 mL
    60 mM 0.0514 mL 0.2570 mL 0.5140 mL 1.2851 mL
    80 mM 0.0386 mL 0.1928 mL 0.3855 mL 0.9638 mL
    100 mM 0.0308 mL 0.1542 mL 0.3084 mL 0.7710 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    SCH-23390 hydrochloride Related Classifications

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SCH-23390125941-87-9R-(+)-SCH-23390SCH23390SCH 23390Dopamine Receptor5-HT ReceptorPotassium ChannelSerotonin Receptor5-hydroxytryptamine ReceptorKcsADA1-likeductusconstrictionepileptiformneurologicalenantioselective5‐HT25‐HT1CD5-receptorGIRKInhibitorinhibitorinhibit

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