2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin

Cathepsin

Cathepsin

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Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.

Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.

Cathepsin Isoform Specific Products:

Cathepsin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS03322
    CTSB Human Pre-designed siRNA Set A
    		Inhibitor

    CTSB Human Pre-designed siRNA Set A contains three designed siRNAs for CTSB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSB Human Pre-designed siRNA Set A
  • HY-144813
    Gü2602
    		Inhibitor 98.13%
    Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK). Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen.
    Gü2602
  • HY-112318
    GSK-2793660 free base
    		Inhibitor
    GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 (free base) can be used for the research of bronchiectasis.
    GSK-2793660 free base
  • HY-103353A
    SID 26681509 quarterhydrate
    		Inhibitor 98.02%
    SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G.
    SID 26681509 quarterhydrate
  • HY-N6674
    Diazepinomicin
    		Inhibitor 98.04%
    Diazepinomicin (ECO-4601) is an anticancer and antibacterial agent. Diazepinomicin can be produced by a Micromonospora strain. Diazepinomicin induces Apoptosis. Diazepinomicin inhibits the proteases Rhodesain and Cathepsin L at an IC50 of 70-90 μM. Diazepinomicin possesses anti-inflammatory and anti-tumor activity. Diazepinomicin has demonstrated activity against hepatocellular carcinoma. Diazepinomicin shows antiparasitic activity against trypomastigote forms of Trypanosoma brucei with an IC50 of 13.5 μM. Diazepinomicin exhibits moderate antibacterial activity against specific Gram-positive bacteria, with an MIC of approximately 32 μg/mL.
    Diazepinomicin
  • HY-P3153
    Cathepsin K
    Cathepsin K is a cysteine protease with endo and collagenolytic activities. Cathepsin K induces degradation of bone collagen and can be used for the research of osteoporosis.
    Cathepsin K
  • HY-153613
    Ac-PLVE-FMK
    		Inhibitor 98.0%
    Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer.
    Ac-PLVE-FMK
  • HY-P5898
    Z-Val-Val-Nle-diazomethylketone
    		Inhibitor
    Z-Val-Val-Nle-diazomethylketone is a cathepsin S (CATS) inhibitor. Z-Val-Val-Nle-diazomethylketone significantly inhibits the IFNg-induced upregulation of the MHCII molecules HLA-DR and Ii-p33/35 with an increase of Ii-p10 protein level. Z-Val-Val-Nle-diazomethylketone can be used for dermatological diseases like psoriasis, atopic dermatitis and actinic keratosis research.
    Z-Val-Val-Nle-diazomethylketone
  • HY-P4340
    Arg-Arg-AMC
    Arg-Arg-AMC is a highly selective substrate of Cathepsin B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer.
    Arg-Arg-AMC
  • HY-W796158
    Z-DEVD-CMK
    		Inhibitor 98.99%
    Z-DEVD-CMK is an irreversible inhibitor of most of the cathepsins in vitro.
    Z-DEVD-CMK
  • HY-122161
    JNJ-10311795
    		Inhibitor 98.66%
    JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity.
    JNJ-10311795
  • HY-137392
    Cathepsin L-IN-4
    		98.5%
    Cathepsin L-IN-4 is an inhibitor of cathepsin L with IC50 at nanomolar concentrations.
    Cathepsin L-IN-4
  • HY-N10109A
    Gallinamide A TFA
    		Inhibitor 99.85%
    Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC50: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC50: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC50: 50 nM).
    Gallinamide A TFA
  • HY-162477
    TS-24
    		Inhibitor 98.96%
    TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis.
    TS-24
  • HY-RS03325
    CTSC Human Pre-designed siRNA Set A
    		Inhibitor

    CTSC Human Pre-designed siRNA Set A contains three designed siRNAs for CTSC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSC Human Pre-designed siRNA Set A
  • HY-P4373
    Hepcidin-1 (mouse)
    		Inducer
    Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation.
    Hepcidin-1 (mouse)
  • HY-RS03328
    CTSD Human Pre-designed siRNA Set A
    		Inhibitor

    CTSD Human Pre-designed siRNA Set A contains three designed siRNAs for CTSD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSD Human Pre-designed siRNA Set A
  • HY-P10923
    KYS-1
    		99.34%
    KYS-1 is a selective substrate for cathepsin E with a Km value of 1.9 μM. KYS-1 was incubated with cathepsin E (1.0 ng) with the pH optimum of approximately pH 4.0.
    KYS-1
  • HY-112583
    MIV-247
    		Inhibitor
    MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
    MIV-247
  • HY-P1645B
    Papain (lyophilized powder, ≥10 units/mg protein)
    Papain (lyophilized powder, ≥10 units/mg protein) is a cysteine protease of the peptidase C1 family. Papain (lyophilized powder, ≥10 units/mg protein) enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain (lyophilized powder, ≥10 units/mg protein) can induce pulmonary emphysema. Papain (lyophilized powder, ≥10 units/mg protein) can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.
    Papain (lyophilized powder, ≥10 units/mg protein)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Cathepsin Isoform Comparison

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