1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. MIV-247

MIV-247 

Cat. No.: HY-112583
Handling Instructions

MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

For research use only. We do not sell to patients.

MIV-247 Chemical Structure

MIV-247 Chemical Structure

CAS No. : 1352817-76-5

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Top Publications Citing Use of Products

Publications Citing Use of MCE MIV-247

    MIV-247 purchased from MCE. Usage Cited in: J Cell Physiol. 2021 Feb;236(2):1309-1320.

    Western blots showing protein expression of cleaved caspase‐8, cleaved caspase‐3, and cleaved PARP in the myocardium of sham and myocardial I/R mice.
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    Description

    MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

    IC50 & Target

    IC50: 2.1 nM (Human Cathepsin S), 4.2 nM (Mouse Cathepsin S), 7.5 nM (Cynomolgus monkey Cathepsin S)[1]

    In Vivo

    Oral administration of MIV-247 (100-200 µmol/kg) dose-dependently attenuates mechanical allodynia by up to approximately 50% reversal when given as a single dose or when given twice daily for 5 days. Cathepsin S inhibition with MIV-247 exerts significant antiallodynic efficacy alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects or inducing pharmacokinetic interactions[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    391.39

    Formula

    C₁₇H₂₄F₃N₃O₄

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
    Animal Administration
    [1]

    Mice[1]

    MIV-247 is administered via oral gavage to Male C57BL/6 mice (20-30 g) at a dose volume of 5 ml/kg at doses up to 200 µmol/kg. In the PK studies, seven blood samples (20 µL) are drawn from the lateral saphenous vein of each mouse at 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 5 hours, and 7 hours postdose[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    Product Name:
    MIV-247
    Cat. No.:
    HY-112583
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