2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. mAChR Endogenous Metabolite
  4. Choline bitartrate

重酒石酸コリン  (Synonyms: Choline bitartrate)

製品番号: HY-101036 純度: 98.0%
COA 取扱説明書 Technical Support

Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders. Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 87-67-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 38 在庫あり
Solution
10 mM * 1 mL in DMSO USD 38 在庫あり
Solid
100 mg $35 在庫あり
500 mg $55 在庫あり
1 g $75 在庫あり
5 g $180 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Other Forms of Choline bitartrate:

重酒石酸コリン 関連抗体

Top Publications Citing Use of Products

    Choline bitartrate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573.  [Abstract]

    Choline (30 μM, 24 h) demonstrated no cytotoxic effects but partially mitigated the inhibition of cell viability induced by EHDPP in HTR-8/SVneo and JEG-3 cells.

    Choline bitartrate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573.  [Abstract]

    Choline (30 μM, 24 h) reversed EHDPP-induced cell migration inhibition in HTR-8/SVneo cells.

    Choline bitartrate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573.  [Abstract]

    Choline (30 μM, 24 h) reversed the EHDPP-induced decrease of mRNA levels of TNF-α, IL-6, and IL-1β in HTR-8/SVneo cells.

    Choline bitartrate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573.  [Abstract]

    Choline supplementation (25 mM choline-containing water for 31.5 days) significantly increased uterine size, fetal weight, placental weight, and placental diameter that were reduced by EHDPP exposure.

    Choline bitartrate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573.  [Abstract]

    Choline supplementation (25 mM choline-containing water for 31.5 days) alleviated the decrease in mRNA expression of the proliferation marker Ki67 and the vascular differentiation marker CD31 induced by EHDPP.

    mAChR アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2]. Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism[3].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    Choline serves as a precursor component to two major cell membrane components: phosphatidylcholine and sphingomyelin in vitro[3].
    Choline is also a major source for methyl groups via its metabolite, betaine, which participates in S-adenosylmethionine synthesis pathways[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    重酒石酸コリン 関連抗体
    体内実験

    Choline bitartrate (oral gavage; 300 mg/kg vs. 5 g/kg) is administrated. Choline restriction (300 mg/kg) provokes robust ketosis and weight loss in mice, also causes significant hepatic steatosis, inflammation, and cellular injury. when Choline is repleted, moderate ketosis and hepatic fat accumulation can be attenuated[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    253.25

    分子式

    C9H19NO7
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OCC[N+](C)(C)C.O=C(O)[C@H](O)[C@@H](O)C([O-])=O
    Structure Classification
    Initial Source

    human milk
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 120 mg/mL (473.84 mM; Need ultrasonic)

    DMSO : 55 mg/mL (217.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9487 mL 19.7433 mL 39.4867 mL
    5 mM 0.7897 mL 3.9487 mL 7.8973 mL
    10 mM 0.3949 mL 1.9743 mL 3.9487 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.75 mg/mL (10.86 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.75 mg/mL (10.86 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (394.87 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.9487 mL 19.7433 mL 39.4867 mL 98.7167 mL
    5 mM 0.7897 mL 3.9487 mL 7.8973 mL 19.7433 mL
    10 mM 0.3949 mL 1.9743 mL 3.9487 mL 9.8717 mL
    15 mM 0.2632 mL 1.3162 mL 2.6324 mL 6.5811 mL
    20 mM 0.1974 mL 0.9872 mL 1.9743 mL 4.9358 mL
    25 mM 0.1579 mL 0.7897 mL 1.5795 mL 3.9487 mL
    30 mM 0.1316 mL 0.6581 mL 1.3162 mL 3.2906 mL
    40 mM 0.0987 mL 0.4936 mL 0.9872 mL 2.4679 mL
    50 mM 0.0790 mL 0.3949 mL 0.7897 mL 1.9743 mL
    60 mM 0.0658 mL 0.3291 mL 0.6581 mL 1.6453 mL
    80 mM 0.0494 mL 0.2468 mL 0.4936 mL 1.2340 mL
    100 mM 0.0395 mL 0.1974 mL 0.3949 mL 0.9872 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Choline bitartrate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Choline bitartrate87-67-2mAChREndogenous MetaboliteMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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    製品名:
    Choline bitartrate
    製品番号:
    HY-101036
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