2. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling Cell Cycle/DNA Damage Epigenetics
  3. PROTACs EGFR PARP
  4. DP-C-4

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP.

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DP-C-4

DP-C-4 화학구조

CAS No. : 2661609-36-3

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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Based on 1 Customer Validation

DP-C-4 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All EGFR Isoform Specific Products:

View All Isoforms
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].

IC50 & Target[1]

Cereblon

 

In Vitro

DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DP-C-4 Related Antibodies

Western Blot Analysis[1]

Cell Line: SW1990 cells
Concentration: 1 μM, 3 μM, 5 μM, 10 μM, 30 μM, 50 μM
Incubation Time: 24 hours
Result: Had degradation effects on EGFR and PARP simultaneously in SW1990 cells.
분자량

1450.93

화학식

C72H78ClF2N15O14
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(CCCCCNC(C(NC(CCCCCOC4=C(OC)C=C(N=CN=C5NC6=CC=C(F)C(Cl)=C6)C5=C4)=O)COCC7=CN(CCOCCOCCNC8=CC=CC(C(N9C%10CCC(NC%10=O)=O)=O)=C8C9=O)N=N7)=O)=O)CC3)=O)=C2)C%11=C1C=CC=C%11
선적

Shipping with dry ice.
보관

-80°C, stored under nitrogen
용액&용해도
In Vitro: 

DMSO : 12 mg/mL (8.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6892 mL 3.4461 mL 6.8921 mL
5 mM 0.1378 mL 0.6892 mL 1.3784 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.

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In Vivo Dissolution Calculator
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순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6892 mL 3.4461 mL 6.8921 mL 17.2303 mL
5 mM 0.1378 mL 0.6892 mL 1.3784 mL 3.4461 mL
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DP-C-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DP-C-42661609-36-3PROTACsEGFRPARPEpidermal growth factor receptorErbB-1HER1poly ADP ribose polymerasePROTACCRBNE3ligandsdegradationInhibitorinhibitorinhibit

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Inquiry Information

상품명:
DP-C-4
Cat. No.:
HY-141481
수량:
MCE Japan Authorized Agent:

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