L-Selenocystine (Synonyms: セレノ-L-シスチン)

Name: L-Selenocystine
Brand: MedChemExpress
SKU: HY-129960
Rating: 5.0 (2 reviews)

製品番号: HY-129960 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity.

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カスタムペプチド

L-Selenocystine 構造式

CAS 番号 : 29621-88-3

容量	価格（税別）	在庫状況	数量
25 mg	$25	在庫あり	Estimated Time of Arrival: December 31
50 mg	$40	在庫あり	Estimated Time of Arrival: December 31
100 mg	$68	在庫あり	Estimated Time of Arrival: December 31
250 mg	$132	在庫あり	Estimated Time of Arrival: December 31
500 mg		お問い合わせ
1 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of L-Selenocystine:

Selenocystine 在庫あり

顧客検証

Caspase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

Bcl-2 Family アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	3.6 3 Compound: 1	Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
A-375	IC₅₀	3.6 3 Compound: 1	Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
A-375	IC₅₀	3.6 3 Compound: 1	Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
CNE-2	IC₅₀	5.6 3 Compound: 1	Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
CNE-2	IC₅₀	5.6 3 Compound: 1	Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
CNE-2	IC₅₀	5.6 3 Compound: 1	Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
HL-60	IC₅₀	34.5 3 Compound: 1	Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
HL-60	IC₅₀	34.5 3 Compound: 1	Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
HL-60	IC₅₀	34.5 3 Compound: 1	Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
SW-620	IC₅₀	7.3 3 Compound: 1	Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
SW-620	IC₅₀	7.3 3 Compound: 1	Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
SW-620	IC₅₀	7.3 3 Compound: 1	Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]

体外実験

L-Selenocystine (8-32 μM; 24 h) can inhibit the proliferation of HepG2 cells (IC₅₀: 5.444 μM) and induce the production of ROS and apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HepG2
Concentration:	8, 16, 32 μM
Incubation Time:	24 h
Result:	Significantly inhibited HepG2 cell growth with increasing concentration.

Western Blot Analysis^[1]

Cell Line:	HepG2
Concentration:	8, 16, 32 μM
Incubation Time:	/
Result:	Inhibited the levels of Bid, Bax, Cleaved Caspase-9, Cleaved Caspase-3 and Cleaved PARP. Reduced the levels of Bcl2.

分子量

334.09

分子式

C₆H₁₂N₂O₄Se₂

CAS 番号

29621-88-3

Appearance

Solid

Color

Light brown to yellow

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 5.88 mg/mL (17.60 mM; ultrasonic and warming and adjust pH to 1 with HCl and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9932 mL	14.9660 mL	29.9321 mL
5 mM	0.5986 mL	2.9932 mL	5.9864 mL
10 mM	0.2993 mL	1.4966 mL	2.9932 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 98.0%

Select Batch:

データシート (272 KB) SDS (788 KB)

COA (244 KB) HNMR (129 KB)

取扱説明書 (2659 KB)

参考文献

[1]. CHEN H, et al. L-Selenocystine induce HepG2 cells apoptosis through ROS-mediated signaling pathways. Biocell, 2022, 46(10).

[2]. Hsu WL, et al. Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis. Cell Death Dis. 2022 Dec 20;13(12):1060. [Content Brief]

[3]. Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74.Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74. [Content Brief]

[4]. Roy J, et al. Optically active selenium-containing amino acids. The synthesis of L-selenocystine and L-selenolanthionine. J Org Chem. 1970 Feb;35(2):510-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.9932 mL	14.9660 mL	29.9321 mL	74.8301 mL
	5 mM	0.5986 mL	2.9932 mL	5.9864 mL	14.9660 mL
	10 mM	0.2993 mL	1.4966 mL	2.9932 mL	7.4830 mL
	15 mM	0.1995 mL	0.9977 mL	1.9955 mL	4.9887 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

L-Selenocystine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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L-Selenocystine (Synonyms: セレノ-L-シスチン)

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Other Forms of L-Selenocystine:

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生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

L-Selenocystine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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L-Selenocystine (Synonyms: セレノ-L-シスチン)

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Other Forms of L-Selenocystine:

L-Selenocystine 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Caspase アイソフォーム固有の製品をすべて表示:

Bcl-2 Family アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

L-Selenocystine 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

L-Selenocystine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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