Nicotinamide riboside tartrate

Name: Nicotinamide riboside tartrate
Brand: MedChemExpress
SKU: HY-123033B
Rating: 5.0 (25 reviews)

製品番号: HY-123033B 純度: 98.07%: Data Sheet SDS COA 取扱説明書
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Nicotinamide riboside tartrate, an orally active NAD⁺ precursor, increases NAD⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

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CAS 番号 : 2415657-86-0

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 60	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 60	在庫あり	Estimated Time of Arrival: December 31
Solid
100 mg	$55	在庫あり	Estimated Time of Arrival: December 31
500 mg	$88	在庫あり	Estimated Time of Arrival: December 31
1 g		お問い合わせ
5 g		お問い合わせ

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カスタマーレビュー

Based on 25 publication(s) in Google Scholar

Other Forms of Nicotinamide riboside tartrate:

顧客検証

Bio/Physico-chemical Assay

Histological Imaging/Staining

Cell Imaging/Staining

In Vivo Efficacy Study

IHC

2D/3D Cell Culture and Differentiation

Cell Proliferation/Viability Assay

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]; Effect of SIRT3 agonist (Nicotinamide riboside chloride; 0-1600 μM) on the proliferation of MC3T3-E1 cells was determined by CCK-8 assay after 2 days of stimulation

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]; IF staining of SIRT3, BNIP3, NIX and DRP1 expression in MC3T3-E1 cells treated with DEX and SIRT3 agonist (800 μm).

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]; WB analysis of SIRT3, BNIP3, NIX, DRP1, MFN1 and MFN2 expression in MC3T3-E1 cells treated with DEX and SIRT3 agonist (800 μM).

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Mar 31.; Representative hematoxylin and eosin (H&E)-stained sections of small intestines were collected at the end of the experiment (NR:Nicotinamide riboside,400 mg/kg/day； po for 4 weeks) or vehicle (phosphate buffer; at the same dose and volume as NR) once a day after irradiation exposure in C57BL/6 mouse)

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Mar 31.; Immunofluorescence detection of Ki-67 and ZO-1 in IECs between groups with NR (Nicotinamide riboside; 0.5 mM; 24 h).

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Mar 31.; Morphology of the SI and colon (NR:Nicotinamide riboside,400 mg/kg/day； po for 4 weeks) or vehicle (phosphate buffer; at the same dose and volume as NR) once a day after irradiation exposure in C57BL/6 mouse)

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2024 Jul 1;65(8):1. [Abstract]; The effect of different concentrations of NR (Nicotinamide riboside chloride;200,400, 800, 1000 μM) on primary human trabecular meshwork cells' viability after 24 and 72 hours of treatment, was determined by using the CCK-8 assay

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Aug 9:117066. [Abstract]; WB images of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions in DRG tissues. Quantification of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions normalized with β-actin expressions and the Saline+Saline treated samples was set to 1 (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR (400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Aug 9:117066. [Abstract]; The representative images depicting the expression of AcK68-MnSOD in each group were utilized for immunohistochemical detection (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR(400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Cells. 2023 Oct 2;12(19):2396. [Abstract]; THP-1 cells were supplemented with 200 µM NR (Nicotinamide riboside chloride) for 4 h before treatment with CEES or HN2 in growth medium (“Ctrl”) for 30 min. The “0” refers to solvent control. After exposure, cells were incubated with fresh growth medium with or without 200 µM NR for 20 h, and cell viability was measured with alamarBlue assay

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Mar 2;6(1):235. [Abstract]; The cells were pretreated with NR (0.5 µM) for 1 h followed by post-incubation with LPS (1 µg/mL) or H2O2 (100 µM) for 24 h, quantitative analysis of cell viability in each group after LPS stimulation and H2O2 stimulation.

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Nov:57:102507. [Abstract]; MitoParaquat (0.1 μM, 30 min) abolished the inhibition of platelet aggregation by nicotinamide riboside (1 mM, 30 min) or olaparib (20 μM, 30 min) in resting platelets from LST patients.

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Nov:57:102507. [Abstract]; MitoParaquat (0.1 μM, 30 min) did not interrupt the improvements in mitochondrial respiration induced by nicotinamide riboside (1 mM) or olaparib (20 μM) in resting platelets from LST patients.

: Nicotinamide riboside tartrate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2021 Nov 10;11(1):192.; Relative ATP, NAD+, NADH, and NAD+/NADH levels in NR (Nicotinamide ribosid, 100 mM, 24 h) treatment SY5Y cells.

Sirtuin アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Nicotinamide riboside tartrate, an orally active NAD⁺ precursor, increases NAD⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities^[1]. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease^[2].

IC₅₀ & Target^[1]

SIRT1

SIRT3

Human Endogenous Metabolite

体外実験

Nicotinamide riboside tartrate (0.5 mM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2^[1].
Nicotinamide riboside tartrate increases intracellular and mitochondrial NAD⁺ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM^[1].
Nicotinamide riboside tartrate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HEK293T cells
Concentration:	0.5 mM
Incubation Time:	24 hours
Result:	Reduced the acetylation status of Ndufa9 and SOD2.

体内実験

Chronic Nicotinamide riboside tartrate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD⁺ content in a tissue-specific manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	10-week-old C57Bl/6J mice^[1]
Dosage:	400 mg/kg
Administration:	PO; daily; for 16 weeks
Result:	Increased plasma and intracellular NAD⁺ content in a tissue-specific manner.

分子量

404.33

分子式

C₁₅H₂₀N₂O₁₁

CAS 番号

2415657-86-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C([O-])=O)[C@@H](O)C(O)=O.NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O

Structure Classification

Others

Initial Source

Endogenous metabolite

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 100 mg/mL (247.32 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4732 mL	12.3661 mL	24.7323 mL
5 mM	0.4946 mL	2.4732 mL	4.9465 mL
10 mM	0.2473 mL	1.2366 mL	2.4732 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 98.07%

Select Batch:

データシート (281 KB) SDS (252 KB)

COA (257 KB) HNMR (283 KB) RP-HPLC (278 KB) MS (68 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. [Content Brief]

[2]. Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. [Content Brief]

[3]. Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.4732 mL	12.3661 mL	24.7323 mL	61.8307 mL
	5 mM	0.4946 mL	2.4732 mL	4.9465 mL	12.3661 mL
	10 mM	0.2473 mL	1.2366 mL	2.4732 mL	6.1831 mL
	15 mM	0.1649 mL	0.8244 mL	1.6488 mL	4.1220 mL
	20 mM	0.1237 mL	0.6183 mL	1.2366 mL	3.0915 mL
	25 mM	0.0989 mL	0.4946 mL	0.9893 mL	2.4732 mL
	30 mM	0.0824 mL	0.4122 mL	0.8244 mL	2.0610 mL
	40 mM	0.0618 mL	0.3092 mL	0.6183 mL	1.5458 mL
	50 mM	0.0495 mL	0.2473 mL	0.4946 mL	1.2366 mL
	60 mM	0.0412 mL	0.2061 mL	0.4122 mL	1.0305 mL
	80 mM	0.0309 mL	0.1546 mL	0.3092 mL	0.7729 mL
	100 mM	0.0247 mL	0.1237 mL	0.2473 mL	0.6183 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.