2. Apoptosis Immunology/Inflammation
  3. TNF Receptor Interleukin Related
  4. Orientin

オリエンチン  (Synonyms: Orientin)

製品番号: HY-N0405 純度: 99.89%
COA 取扱説明書 Technical Support

Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain.

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CAS 番号 : 28608-75-5

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
10 mg $30 在庫あり
25 mg $60 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Other Forms of Orientin:

オリエンチン 関連抗体

Top Publications Citing Use of Products

    Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480.

    Percentage of viable cells after treatment with different concentrations of Orientin (5, 10, 20, 40, 80, 160 μM) for 24 or 48 h.

    Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480.

    Quantitative analysis of the DHE staining as well as representative images by treatment with Orientin (20 μM).

    Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480.

    The MitoSox (red) stain was used to conduct the MitoROS staining. The intensity of fluorescence as measured by flow cytometry in relation to its mean value by treatment with Orientin (20 μM).

    Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480.

    Western blot analysis comparing the levels of MFN1 and MFN2 expression in HUVECs by treatment with Orientin (20 μM).

    Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480.

    Representative digital images of wound closure for control and Orientin (20 mg/kg) group on day 0, day 5, day 10, and day 15.

    TNF Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

    Interleukin Related アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    KB ED50
    25 μg/mL
    Compound: NSC-133101
    Cytotoxicity against human KB cells
    Cytotoxicity against human KB cells
    		[PMID: 469554]
    体外実験

    Orientin (1 µM) inhibits allergic inflammation in RBL-2H3, mBMMCs, and RPMCs cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    オリエンチン 関連抗体

    Cell Viability Assay[1]

    Cell Line: RBL-2H3, mBMMCs, and RPMCs
    Concentration: 0.01–100 µM
    Incubation Time: 8 h
    Result: Significantly suppressed the levels of histamine and β-hexosaminidase in RBL-2H3, mBMMCs, and RPMCs cells.
    Inhibited the intracellular calcium levels in RBL-2H3, mBMMCs, and RPMCs cells.
    Markedly inhibited the pro-inflammatory cytokines expression and secretion in RBL-2H3 cells.
    Inhibited phosphorylation in RBL-2H3 cells.
    体内実験

    Orientin (0.1–10 mg/kg for p.o.;once) inhibits allergic reaction in PCA mouse model[1].
    Orientin (10–40 mg/kg for i.p.;once daily for 12 days) has an anti-neuroinflammatory effect in SNL rat model[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: PCA mouse model[1]
    Dosage: 0.1–10 mg/kg
    Administration: Oral gavage (p.o.); Euthanized mouse after 1 h
    Result: Significantly suppressed PCA reactions in PCA mouse model.
    Animal Model: SNL rat model[2]
    Dosage: 10, 20, 40 mg/kg
    Administration: Intraperitoneal injection (i.p.); Once daily for 12 days
    Result: Alleviated the downreg-ulation of PWL and promoted the behavior recovery in SNL rat model.
    Decreased the levels of IL-6, IL-1β and TNF-α.
    Increased the level of anti-inflammatory IL-10.
    Down-regulated the level of MDA.
    分子量

    448.38

    分子式

    C21H20O11
    CAS 番号
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O[C@@H]1[C@@H](O)[C@H](C2=C(O)C=C(O)C3=C2OC(C4=CC=C(O)C(O)=C4)=CC3=O)O[C@H](CO)[C@H]1O
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    DMSO : 31.25 mg/mL (69.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2303 mL 11.1513 mL 22.3025 mL
    5 mM 0.4461 mL 2.2303 mL 4.4605 mL
    10 mM 0.2230 mL 1.1151 mL 2.2303 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体積 （開始）

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    濃度 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.89%

    COA (255 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2303 mL 11.1513 mL 22.3025 mL 55.7563 mL
    5 mM 0.4461 mL 2.2303 mL 4.4605 mL 11.1513 mL
    10 mM 0.2230 mL 1.1151 mL 2.2303 mL 5.5756 mL
    15 mM 0.1487 mL 0.7434 mL 1.4868 mL 3.7171 mL
    20 mM 0.1115 mL 0.5576 mL 1.1151 mL 2.7878 mL
    25 mM 0.0892 mL 0.4461 mL 0.8921 mL 2.2303 mL
    30 mM 0.0743 mL 0.3717 mL 0.7434 mL 1.8585 mL
    40 mM 0.0558 mL 0.2788 mL 0.5576 mL 1.3939 mL
    50 mM 0.0446 mL 0.2230 mL 0.4461 mL 1.1151 mL
    60 mM 0.0372 mL 0.1859 mL 0.3717 mL 0.9293 mL
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    Orientin Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Orientin28608-75-5TNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILcardioprotectionneuroprotectiveIL-6IL-1βTNF-αInhibitorinhibitorinhibit

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    製品名:
    Orientin
    製品番号:
    HY-N0405
    数量:
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