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Results for "

Aβ-IN-5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (4) 5-HT Receptor (1) Adrenergic Receptor (1) AMPK (1) Amyloid-β (5) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (4) Autophagy (13) Bacterial (1) Biochemical Assay Reagents (11) Cannabinoid Receptor (10) CDK (3) Cholinesterase (ChE) (2) Drug Derivative (4) Drug Intermediate (1) Drug Metabolite (2) Endogenous Metabolite (13) Fluorescent Dye (1) Glycosidase (3) GSK-3 (1) IFNAR (1) IKK (2) Isotope-Labeled Compounds (11) Lipoxygenase (1) LPL Receptor (1) Mucin (1) NF-κB (2) Notch (1) Nucleoside Antimetabolite/Analog (1) Oxytocin Receptor (1) PDGFR (1) PI4K (1) RAR/RXR (2) Reactive Oxygen Species (ROS) (3) Reference Standards (5) STAT (1) TGF-beta/Smad (1) TGF-β Receptor (1) Thyroid Hormone Receptor (1) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (1) TRP Channel (10) Xanthine Oxidase (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (13) Metabolic Disease (5) Neurological Disease (17)
Oligonucleotides:	Nucleoside Analogs (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15682

TTNPB 5 Publications Verification Ro 13-7410; ArotINoid acid; AGN191183	RAR/RXR Autophagy Apoptosis	Cancer
TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC₅₀s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.

HY-B0172A

Isoallolithocholic acid 3 Publications Verification 3β-Hydroxy-5α-cholanic acid	Drug Derivative	Inflammation/Immunology
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation .

HY-10012

AZD-5438 Maximum Cited Publications 14 Publications Verification	CDK	Cancer
AZD-5438 is a potent CDK1, CDK2, and CDK9 inhibitor, with IC₅₀s of 16 nM, 6 nM, and 20 nM in cell-free assays, respectively. AZD-5438 shows less inhibition activity against GSK3β, CDK5 and CDK6 .

HY-B0151

Pregnenolone Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-N0366

Sennoside B 3 Publications Verification	PDGFR	Inflammation/Immunology
Sennoside B is a potent and orally active platelet-derived growth factor (PDGF) inhibitor. Sennoside B inhibits cell proliferation and the expression of phosphorylation of PDGFR-β, STAT-5, AKT and ERK induced by PDGF-BB. Sennoside B shows gastroprotective activities. Sennoside B has the potential for the research of gastritis .

HY-137276

5-Bromo-3-indolyl β-D-galactopyranoside Bluo-Gal	Fluorescent Dye Glycosidase	Others
5-Bromo-3-indolyl β-D-galactopyranoside (Bluo-Gal) is a chromogenic substrate for *β-galactosidase*. 5-Bromo-3-indolyl β-D-galactopyranoside is hydrolyzed by the enzyme to generate a 5-bromoindole intermediate, which is further oxidized to form an insoluble blue precipitate. 5-Bromo-3-indolyl β-D-galactopyranoside can specifically recognize bacterial β-galactosidases (such as the product of the Escherichia coli lacZ gene) and reacts at pH 7.4, making it suitable for light and electron microscopic observations. 5-Bromo-3-indolyl β-D-galactopyranoside can be used in histochemical detection of reporter gene expression in transgenic organisms, such as the localization analysis of β-galactosidase activity in mouse embryos or muscle tissues .

HY-B1739

Pregnenolone monosulfate Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication . Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-113315

3b-Hydroxy-5-cholenoic acid	Endogenous Metabolite	Metabolic Disease
3β-Hydroxy-5-cholenoic acid is a steroidal monohydroxy bile acid and serves as a substrate for sulfation reactions. It is applicable to the research of extrahepatic biliary atresia and recurrent intrahepatic cholestasis of pregnancy .

HY-110189

Pregnenolone monosulfate sodium Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-W587861

5β-Dihydroprogesterone 1 Publications Verification 5βDHP	Oxytocin Receptor	Endocrinology
5β-Dihydroprogesterone (5βDHP) is the metabolite of Progesterone (HY-N0437). 5β-Dihydroprogesterone binds to oxytocin receptor, reduces the Oxytocin (HY-17571)-induced calcium signal transduction, thereby exhibiting the tocolytic activity .

HY-111930

5-Iodo-indirubin-3'-monoxime	GSK-3 CDK	Cancer
5-Iodo-indirubin-3'-monoxime is a potent *GSK-3β, CDK5/P25* and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC₅₀s of 9, 20 and 25 nM, respectively .

HY-128437

TGFβ-IN-5 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
TGFβ-IN-5 is a type I transforming growth factor-β receptor (TGF-β R1) kinase inhibitor with an IC₅₀ value of 0.0485 μM. TGFβ-IN-5 reverses the effect of TGF-β-mediated cell activation on the expression of fibrosis-related genes. TGFβ-IN-5 can be used in the research of fibroproliferative diseases .

HY-B0151R

Pregnenolone (Standard) 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one (Standard)	Reference Standards Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone (Standard) is the analytical standard of Pregnenolone. This product is intended for research and analytical applications. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-N1510

Kaempferol 3-O-gentiobioside	Glycosidase Notch Toll-like Receptor (TLR) NF-κB Mucin Reactive Oxygen Species (ROS) Bacterial TGF-beta/Smad Anaplastic lymphoma kinase (ALK)	Infection Inflammation/Immunology Cancer
Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a K_a value of 57 µM against human NOTCH1 and an IC₅₀ value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of *MUC5AC, reduces nitrite and ROS* levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the *TGF-β/ALK5/Smad* signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma . It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer .

HY-133972

3β-Hydroxy-5-cholestenoic acid	Biochemical Assay Reagents
3β-Hydroxy-5-cholestenoic acid is a kind of biochemical reagent.

HY-123349

5α-Hydroxy-6-keto cholesterol	Drug Metabolite	Cardiovascular Disease
5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC₅₀ of 350 nM .

HY-130502

5β,6β-Epoxycholestanol Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol	Apoptosis	Inflammation/Immunology Cancer
5β,6β-epoxycholestanol (Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol) is an oxysterol. 5β,6β-epoxycholestanol induces cytotoxicity in bronchial epithelial cells. 5β,6β-epoxycholestanol induces lactate dehydrogenase (LDH) release and apoptosis in lymphoma cells undergoing macrophage differentiation . 5β,6β-epoxycholestanol is applicable to research related to atherosclerosis .

HY-147055

THR-β agonist 5	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
THR-β agonist 5 is a THR-β agonist. THR-β agonist 5 can be used for the research of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis .

HY-133966

6α-Hydroxy-5α-cholestane 5α-Cholestane-3β,6α-diol	Reactive Oxygen Species (ROS)	Others
6α-Hydroxy-5α-cholestane (5α-Cholestane-3β,6α-diol) is an oxysterol that promotes the production of superoxide anions in SK-N-BE cells at concentrations of 50 μM and 100 μM .

HY-147980

*Aβ-IN-5*	Amyloid-β Cholinesterase (ChE)	Neurological Disease
Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC₅₀ values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity .

HY-107819S

5α-Cholestan-3β-ol-d5 Dihydrocholesterol-d₅; 5α-Cholestanol-d₅; NSC 18188-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Others
5α-Cholestan-3β-ol-d₅ is the deuterium labeled 5α-Cholestan-3β-ol. 5α-Cholestan-3β-ol is a derivitized steroid compound .

HY-B0151S2

Pregnenolone-d4-1 3β-Hydroxy-5-pregnen-20-one-d₄-1	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-78766

3beta,6alpha,17beta-Trihydroxy-5alpha-androstane	Drug Intermediate	Others
3beta,6alpha,17beta-Trihydroxy-5alpha-androstane is a drug intermediate for synthesis of various active compounds.

HY-110189S1

Pregnenolone monosulfate-d4 sodium 3β-Hydroxy-5-pregnen-20-one monosulfate-d4 sodium	Isotope-Labeled Compounds Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate-d₄ sodium is the deuterium labeled Pregnenolone monosulfate sodium (HY-110189) . Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-163320

AChE/Aβ-IN-5	Cholinesterase (ChE) Amyloid-β	Neurological Disease
AChE/Aβ-IN-5 (compound AV-2) is a bifunctional inhibitor that targets AChE and auto-induced Aβ (Amyloid-β) aggregation. AChE/Aβ-IN-5 can significantly improve scopolamine- and Aβ-induced cognitive impairment in mice .

HY-133972S

3β-Hydroxy-5-cholestenoic acid-d5	Isotope-Labeled Compounds	Others
3β-Hydroxy-5-cholestenoic acid-d₅ is deuterium labeled 3β-Hydroxy-5-cholestenoic acid.

HY-100206

5α-Androstane-3β,5,6β-triol	AMPK	Neurological Disease
5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo .

HY-138979

Lipoxygenin	Lipoxygenase	Others
Lipoxygenin is a non-redox 5-lipoxygenase (5-LO) inhibitor with an IC₅₀ of 5 μM. Lipoxygenin modulates the β-catenin-5-LO complex, inducing a decrease in β-catenin and 5-LO levels in the nucleus .

HY-178915

ITA-5	IKK IFNAR STAT	Inflammation/Immunology
ITA-5 is a TBK1 inhibitor based on the structure of itaconic acid. can significantly inhibit the secretion of *IFN-β*. ITA-5 can inhibit the phosphorylation of TBK1, IRF3, and STAT1. ITA-5 can be used for research on autoimmune diseases and excessive inflammation .

HY-147660

IMMH001	LPL Receptor	Inflammation/Immunology
IMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research .

HY-B0151S

Pregnenolone-d4 3β-Hydroxy-5-pregnen-20-one-d₄	Isotope-Labeled Compounds Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d₄ is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-164136

17β-HSD5 inhibitor 1	17β-HSD	Metabolic Disease
17β-HSD5 inhibitor 1 (Compound 29) is a potent *17β-HSD5* inhibitor, with an IC₅₀ of 2.9 nM in HEK-293 cells overexpressing human 17β-HSD5 .

HY-164138

17β-HSD5 inhibitor 3	17β-HSD	Cancer
17β-HSD5 inhibitor 3 (Compound 31) is an orally active inhibitor for *17β-HSD5* with an IC₅₀ of 69 nM .

HY-164137

17β-HSD5 inhibitor 2	17β-HSD	Cancer
17β-HSD5 inhibitor 2 (Compound 30) is an inhibitor for 17β-hydroxysteroid dehydrogenases 5 (17β-HSD 5) with IC₅₀ of 40 nM .

HY-N10893

*(-)-β-Peltatin-5-O-beta-D-glucopyranoside*	Others	Others
(-)-β-Peltatin-5-O-beta-D-glucopyranoside is an active compound. (-)-β-Peltatin-5-O-beta-D-glucopyranoside can be isolated from P. peltatum L .

HY-P4894

*Amyloid β-Protein (5-42)*	Amyloid-β	Others
Amyloid β-Protein (5-42) is aAβ Fragment.

HY-172256

PI4KIII beta inhibitor 5	PI4K	Cancer
PI4KIII beta inhibitor 5 is a PI4KIIIβ inhibitor with an IC₅₀ of 19 nM. PI4KIII beta inhibitor 5 can induce cancer cell apoptosis (Apoptosis), cell cycle arrest at the G2/M phase, and autophagy (Autophagy) by inhibiting the PI3K/AKT pathway. PI4KIII beta inhibitor 5 has also demonstrated significant antitumor activity in the H446 xenograft model of small cell lung cancer. PI4KIII beta inhibitor 5 can be used for research in the field of cancer therapy .

HY-164140

EM 1404	17β-HSD	Others
EM 1404 is a *17β-HSD5* inhibitor (IC₅₀: 3.2 nM) .

HY-B0172AS1

Isoallolithocholic acid-d4 3β-Hydroxy-5α-cholanic acid-d₄	Isotope-Labeled Compounds Others	Inflammation/Immunology
Isoallolithocholic acid-d₄ (3β-Hydroxy-5α-cholanic acid-d₄) is deuterium labeled Isoallolithocholic acid. Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation .

HY-146767S

(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d4	Isotope-Labeled Compounds	Others
(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d₄ is deuterium labeled (3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid.

HY-P990293

Anti-Mouse CD122/IL-2Rβ Antibody (5H4)	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can inhibit IL-2. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can be used for the researches of cancer and immunology, such as hepatocellular carcinoma .

HY-N17596

11β,17β-Dihydroxy-5α-androstan-3-one 11OHDHT; 5a-Dihydro-11β-hydroxytestosterone	Others	Cancer
11β,17β-Dihydroxy-5α-androstan-3-one (11OHDHT) is a C11-oxy C₁₉ steroid, has a role as an androgen. 11β,17β-Dihydroxy-5α-androstan-3-one can be used for prostate cancer research .

HY-N13070

3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid	Others	Metabolic Disease
3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid (compound 89) can be isolated from the secretions of the fungus Poria cocos (Schw.) .

HY-N1661

2α,3β-Dihydroxypterodontic acid	Others	Others
2α,3β-Dihydroxypterodontic acid is a natural product used for synthesize 2α,3β-dihydroxy-5,11(13)-dien-eudesman-12-oic acid .

HY-B0172AR

Isoallolithocholic acid (Standard) 3β-Hydroxy-5α-cholanic acid (Standard)	Drug Derivative Reference Standards	Inflammation/Immunology
Isoallolithocholic acid (Standard) is the analytical standard of Isoallolithocholic acid. This product is intended for research and analytical applications. Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation[1].

HY-15682R

TTNPB (Standard) Ro 13-7410 (Standard); ArotINoid acid (Standard); AGN191183 (Standard)	Reference Standards RAR/RXR Autophagy Apoptosis	Cancer
TTNPB (Standard) is the analytical standard of TTNPB. This product is intended for research and analytical applications. TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.

HY-180119

IKKβ-IN-5	IKK NF-κB Autophagy	Cancer
IKKβ-IN-5 is an orally active and selective IKKβ inhibitor with an IC₅₀ of 7.5 nM. IKKβ-IN-5 directly inhibits IKKβ phosphorylation and attenuates NF κB mediated inflammatory and survival signals while promoting autophagy flux. IKKβ-IN-5 exhibits a 6-fold selectivity forIKKβ over the homologous kinase IKKα. IKKβ-IN-5 exerts robust antiproliferative effects through a dual mechanism involving G₂/M phase cell cycle arrest and autophagy activation, even under inflammatory stimulation in vitro. IKKβ-IN-5 demonstrates favorable pharmacokinetics and suppresses tumor growth in vivo. IKKβ-IN-5 can be used for colorectal cancer and potentially other inflammation driven malignancies research .

HY-N7170

(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid	Glycosidase	Metabolic Disease
(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is a α-Glucosidase inhibitor with an IC₅₀ value of 577.7 µM .

HY-N3995S

5β-Dihydrocortisol-d6	Isotope-Labeled Compounds Apoptosis Drug Metabolite	Cancer
5β-Dihydrocortisol-d₆ is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis ^[5].

HY-10012R

AZD-5438 (Standard)	Reference Standards CDK	Cancer
AZD-5438 (Standard) is the analytical standard of AZD-5438. This product is intended for research and analytical applications. AZD-5438 is a potent CDK1, CDK2, and CDK9 inhibitor, with IC50s of 16 nM, 6 nM, and 20 nM in cell-free assays, respectively. AZD-5438 shows less inhibition activity against GSK3β, CDK5 and CDK6 .

Cat. No.	Product Name

HY-L069

Anti-Alzheimer's Disease Compound Library

2,065 compounds

Alzheimer’s Disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Despite the significant public health issue that it poses, only few medical treatments have been approved for Alzheimer’s Disease (AD) and these act to control symptoms rather than alter the course of the disease. Discovery of new therapeutic approaches depends on the study of pathology of AD. Recent research findings have led to greater understanding of disease neurobiology in Alzheimer's Disease (AD) and identification of unique targets for drug development. Several important mechanisms have been proposed to explain the underlying pathology of AD, such as Amyloid cascade hypothesis, Tau hypothesis and Cholinergic hypothesis, etc.

MCE offers a unique collection of 2,065 compounds with anti-Alzheimer’s Disease activities or targeting the unique targets of AD. MCE Anti-Alzheimer’s Disease Compound Library is a useful tool for exploring the mechanism of AD and discovering new drugs for AD.

Cat. No.	Product Name	Type

HY-133972

3β-Hydroxy-5-cholestenoic acid	Biochemical Assay Reagents
3β-Hydroxy-5-cholestenoic acid is a kind of biochemical reagent.

HY-130502

5β,6β-Epoxycholestanol Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol	Biochemical Assay Reagents
5β,6β-epoxycholestanol (Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol) is an oxysterol. 5β,6β-epoxycholestanol induces cytotoxicity in bronchial epithelial cells. 5β,6β-epoxycholestanol induces lactate dehydrogenase (LDH) release and apoptosis in lymphoma cells undergoing macrophage differentiation . 5β,6β-epoxycholestanol is applicable to research related to atherosclerosis .

Cat. No.	Product Name	Target	Research Area

HY-P4727

*(β-Asp5)-Delta-Sleep Inducing Peptide* DSIP-isoD	Peptides	Others
(β-Asp5)-Delta-Sleep Inducing Peptide (DSIP-isoD) is a synthetic polypeptide that can be partially hydrolyzed by NaOH or SDS. (β-Asp5)-Delta-Sleep Inducing Peptide can be used to study the catalytic activity of mitochondrial protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) .

HY-P4894

*Amyloid β-Protein (5-42)*	Amyloid-β	Others
Amyloid β-Protein (5-42) is aAβ Fragment.

Cat. No.	Product Name	Target	Research Area	Image

HY-P990293

Anti-Mouse CD122/IL-2Rβ Antibody (5H4)	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can inhibit IL-2. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can be used for the researches of cancer and immunology, such as hepatocellular carcinoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0151

Pregnenolone Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one	Microorganisms Neurological Disease Classification of Application Fields Anti-aging Endogenous metabolite Disease Research Fields Steroids Source Classification	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-N0366

Sennoside B 3 Publications Verification	Quinones Classification of Application Fields Leguminosae Anthraquinones Cassia angustifolia Plants Disease Research Fields Cancer	PDGFR
Sennoside B is a potent and orally active platelet-derived growth factor (PDGF) inhibitor. Sennoside B inhibits cell proliferation and the expression of phosphorylation of PDGFR-β, STAT-5, AKT and ERK induced by PDGF-BB. Sennoside B shows gastroprotective activities. Sennoside B has the potential for the research of gastritis .

HY-B1739

Pregnenolone monosulfate Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate	Endogenous metabolite Steroids Source Classification	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication . Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-113315

3b-Hydroxy-5-cholenoic acid	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
3β-Hydroxy-5-cholenoic acid is a steroidal monohydroxy bile acid and serves as a substrate for sulfation reactions. It is applicable to the research of extrahepatic biliary atresia and recurrent intrahepatic cholestasis of pregnancy .

HY-110189

Pregnenolone monosulfate sodium Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Endogenous metabolite Steroids Source Classification	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-B0151R

Pregnenolone (Standard) 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one (Standard)	Neurological Disease Classification of Application Fields Anti-aging Endogenous metabolite Disease Research Fields Steroids Source Classification	Reference Standards Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone (Standard) is the analytical standard of Pregnenolone. This product is intended for research and analytical applications. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-N1510

Kaempferol 3-O-gentiobioside	Flavonols Structural Classification Flavonoids Sauropus spatulifolius Beille Classification of Application Fields Phenols Polyphenols Metabolic Disease Euphorbiaceae Plants Disease Research Fields Source Classification	Glycosidase Notch Toll-like Receptor (TLR) NF-κB Mucin Reactive Oxygen Species (ROS) Bacterial TGF-beta/Smad Anaplastic lymphoma kinase (ALK)
Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a K_a value of 57 µM against human NOTCH1 and an IC₅₀ value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of *MUC5AC, reduces nitrite and ROS* levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the *TGF-β/ALK5/Smad* signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma . It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer .

HY-N10893

*(-)-β-Peltatin-5-O-beta-D-glucopyranoside*	Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Source Classification	Others
(-)-β-Peltatin-5-O-beta-D-glucopyranoside is an active compound. (-)-β-Peltatin-5-O-beta-D-glucopyranoside can be isolated from P. peltatum L .

HY-N17596

11β,17β-Dihydroxy-5α-androstan-3-one 11OHDHT; 5a-Dihydro-11β-hydroxytestosterone	Structural Classification Endogenous metabolite Steroids Source Classification	Others
11β,17β-Dihydroxy-5α-androstan-3-one (11OHDHT) is a C11-oxy C₁₉ steroid, has a role as an androgen. 11β,17β-Dihydroxy-5α-androstan-3-one can be used for prostate cancer research .

HY-N13070

3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid	Triterpenes Structural Classification Microorganisms Terpenoids Source Classification	Others
3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid (compound 89) can be isolated from the secretions of the fungus Poria cocos (Schw.) .

HY-N1661

2α,3β-Dihydroxypterodontic acid	Crotalaria sessiliflora L. Ketones, Aldehydes, Acids Plants Compositae Source Classification	Others
2α,3β-Dihydroxypterodontic acid is a natural product used for synthesize 2α,3β-dihydroxy-5,11(13)-dien-eudesman-12-oic acid .

HY-N7170

(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid	Ketones, Aldehydes, Acids Verbenaceae Duranta erecta L. Plants Source Classification	Glycosidase
(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is a α-Glucosidase inhibitor with an IC₅₀ value of 577.7 µM .

HY-110189R

Pregnenolone monosulfate sodium (Standard) 3β-Hydroxy-5-pregnen-20-one monosulfate sodium (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy Reference Standards
Pregnenolone monosulfate (sodium) (Standard) is the analytical standard of Pregnenolone monosulfate (sodium). This product is intended for research and analytical applications. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-N17232

5α,6α-Epoxyergosta-8,22-diene-3β,7α-diol	Structural Classification Microorganisms Steroids Source Classification	Drug Derivative
5α,6α-Epoxyergosta-8,22-diene-3β,7α-diol is a natural steroid.

HY-N17230

5α,6α-Epoxyergosta-8(14),22-diene-3β,7α-diol	Structural Classification Microorganisms Steroids Source Classification	Drug Derivative
5α,6α-Epoxyergosta-8(14),22-diene-3β,7α-diol is a natural steroid.

HY-N2457

Laxogenin (25R)-3β-Hydroxy-5α-spirostan-6-one; 6-OxotigogenIN	Structural Classification Allium chinense G. Don Plants Amaryllidaceae Steroids Source Classification	Reactive Oxygen Species (ROS)
Laxogenin ((25R)-3β-Hydroxy-5α-spirostan-6-one; 6-Oxotigogenin) is an orally active myostatin (myostatin) inhibitor. Laxogenin promotes myogenesis and enhances the formation and maturation of myotubes. Laxogenin downregulates ROS. When added to the culture medium for cultured meat production, Laxogenin improves the texture, quality and nutritional value of cultured meat. Laxogenin reduces the average number of tumors in a two-stage mouse lung carcinogenesis model. Laxogenin can be used in research related to myogenesis and lung cancer .

Cat. No.	Product Name	Chemical Structure

HY-107819S

5α-Cholestan-3β-ol-d5
5α-Cholestan-3β-ol-d₅ is the deuterium labeled 5α-Cholestan-3β-ol. 5α-Cholestan-3β-ol is a derivitized steroid compound .

HY-B0151S2

Pregnenolone-d4-1

Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-110189S1

Pregnenolone monosulfate-d4 sodium

Pregnenolone monosulfate-d₄ sodium is the deuterium labeled Pregnenolone monosulfate sodium (HY-110189) . Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-133972S

3β-Hydroxy-5-cholestenoic acid-d5
3β-Hydroxy-5-cholestenoic acid-d₅ is deuterium labeled 3β-Hydroxy-5-cholestenoic acid.

HY-B0151S

Pregnenolone-d4

Pregnenolone-d₄ is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-B0172AS1

Isoallolithocholic acid-d4
Isoallolithocholic acid-d₄ (3β-Hydroxy-5α-cholanic acid-d₄) is deuterium labeled Isoallolithocholic acid. Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation .

HY-146767S

(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d4
(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d₄ is deuterium labeled (3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid.

HY-N3995S

5β-Dihydrocortisol-d6
5β-Dihydrocortisol-d₆ is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis ^[5].

HY-N9453S

5α-Cholesta-7,24-dien-3β-ol-d6
5α-Cholesta-7,24-dien-3β-ol-d₆ is deuterium labeled 5α-Cholesta-7,24-dien-3β-ol. 5α-Cholesta-7,24-dien-3β-ol, a sterol, can be found in hamster cauda epididymal mature spermatozoa .

HY-110189S

Pregnenolone monosulfate sodium-13C2,d2

Pregnenolone monosulfate (sodium)- ¹³C₂,d₂ is the ¹³C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-146776S

5β,6β-Epoxycholestanol-d7
5β,6β-Epoxycholestanol-d₇ is deuterium labeled 5β,6β-Epoxycholestanol.

HY-B0151S3

Pregnenolone-d6

Pregnenolone-d₆ (3β-Hydroxy-5-pregnen-20-one-d₆) is the deuterium labeled Pregnenolone (HY-B0151) . Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

Cat. No.	Product Name		Classification

HY-152678

*6-Methoxypurine-9-β-D-5’(R)-C-methylriboside*		Nucleoside Analogs
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

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