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Results for "

AChE inhibition

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Amyloid-β (5) Apoptosis (1) Bacterial (4) Bcl-2 Family (1) Calcium Channel (1) Carbonic Anhydrase (3) Caspase (1) CDK (1) Cholinesterase (ChE) (45) GSK-3 (1) Insecticide (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Mitochondrial Metabolism (1) MMP (1) Monoamine Oxidase (5) PARP (1) Phosphatase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Serotonin Transporter (1) Sigma Receptor (1) Sodium Channel (1) Tau Protein (2)
By Research Areas:	Cancer (3) Infection (2) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (38)

By Targets:

5-HT Receptor (5)

Amyloid-β (5)

Apoptosis (1)

Bacterial (4)

Bcl-2 Family (1)

Calcium Channel (1)

Carbonic Anhydrase (3)

Caspase (1)

CDK (1)

Cholinesterase (ChE) (45)

GSK-3 (1)

Insecticide (1)

Isotope-Labeled Compounds (1)

MDM-2/p53 (1)

Mitochondrial Metabolism (1)

MMP (1)

Monoamine Oxidase (5)

PARP (1)

Phosphatase (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (1)

Serotonin Transporter (1)

Sigma Receptor (1)

Sodium Channel (1)

Tau Protein (2)

By Research Areas:

Cancer (3)

Infection (2)

Inflammation/Immunology (5)

Metabolic Disease (3)

Neurological Disease (38)

Inhibitors & Agonists

Fluorescent Dyes

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: nAChR mAChR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0740

Jatrorrhizine chloride 3 Publications Verification	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine chloride is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of?AChE?(IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N0749

Jatrorrhizine	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease
Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE* (IC₅₀=872* nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-119979

Cardanol monoene Cardanol C15:1	Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism MMP CDK Caspase Bcl-2 Family PARP MDM-2/p53 Cholinesterase (ChE)	Infection Inflammation/Immunology Cancer
Cardanol monoene (Cardanol C15:1) is a phenolic compound which can be found in cashew nut shell liquid. Cardanol monoene can inhibit cancer cells proliferation, migration, cause S phase arrest, induce apoptosis, ROS production and mitochondrial depolarization. Cardanol monoene downregulates MMP-2, MMP-9, cyclinA1 expression, regulates CDK2, p53, Bax, cytochrome c, cleaved caspase-3, cleaved PARP, Apaf-1 expression and Bax/Bcl-2 ratio. Cardanol monoene shows weak DPPH radical scavenging activity and *AChE* inhibition activity. Cardanol monoene is lethal to Artemia salina nauplii. Cardanol monoene. Cardanol monoene can be used for the research of cancer, infection and inflamation .

HY-N2511

Trimyristin	Cholinesterase (ChE) Phosphatase	Infection Neurological Disease
Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC₅₀ values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity .

HY-N0749A

Jatrorrhizine hydroxide 3 Publications Verification	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE* (IC₅₀=872* nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-W130236

Methylene Violet 3RAX	Cholinesterase (ChE)	Cancer
Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an K_is of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy) .

HY-W540232

4-Methoxyphenyl isothiocyanate 4-Methylphenyl ITC	Cholinesterase (ChE)	Neurological Disease
4-Methoxyphenyl isothiocyanate (4-Methylphenyl ITC) is an antioxidant, with a IC₅₀ value of 1.25 mM for scavenging DPPH radicals. ORAC testing indicates its antioxidant capacity as 11.7 mM TE (indicating that the antioxidant efficacy of this compound is equivalent to 11.7 mmol of Trolox (HY-101445, a standard antioxidant) under the same conditions), and it extends the oxidation process by approximately 9180 seconds in the Briggs–Rauscher reaction. Additionally, 4-Methoxyphenyl isothiocyanate exhibits moderate cholinesterase inhibitory activity, with an inhibition rate of 30.4% against acetylcholinesterase (AChE) and 17.9% against butyrylcholinesterase (BChE). 4-Methoxyphenyl isothiocyanate holds potential for research in the fields of antioxidation and neurological disorders .

HY-W324391

Coumarin 106 Coumarin 478	Cholinesterase (ChE)	Neurological Disease
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC₅₀=4.97 and K_i=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC₅₀=4.56) .

HY-106440

Zifrosilone	Cholinesterase (ChE)	Neurological Disease
Zifrosilone is an orally active acetylcholinesterase (AChE) inhibitor with a mean maximum inhibition of 20.9% at 10 mg. Zifrosilone can be used for the research of neurological disease .

HY-Z8890

Norneostigmine	Cholinesterase (ChE)	Neurological Disease
Norneostigmine is a potent inhibitor of *AChE* that can penetrate the blood-brain barrier. Norneostigmine can achieve a 50% inhibition rate of mouse brain AChE after 10 min treatment, which is close to the inhibitory effect of tetrahydroaminoacridine (57% at 10 min). Norneostigmine can be used to study memory disorders related to Alzheimer's disease and other memory disorders .

HY-179496

ChE/GSK-3β-IN-1	GSK-3 Cholinesterase (ChE) Amyloid-β	Neurological Disease
ChE/GSK-3β-IN-1 (compound 18o) is a potent dual ChE/GSK-3β inhibitor. ChE/GSK-3β-IN-1 exhibits dual inhibition of *AChE* (IC₅₀ = 1.7 μM), butyrylcholinesterase (BChE) (IC₅₀ = 5.3 μM), and GSK-3β (IC₅₀ = 5.7 μM). ChE/GSK-3β-IN-1 inhibits Aβ1-42 self-aggregation. ChE/GSK-3β-IN-1 can be used for Alzheimer’s disease (AD) research .

HY-146142

AChE/BuChE-IN-2	Cholinesterase (ChE) Amyloid-β	Neurological Disease
AChE/BuChE-IN-2 (Compound 5f) is an orally active *AChE* and BuChE inhibitor with IC₅₀ values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC₅₀ of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB .

HY-157982

BChE-IN-28	Cholinesterase (ChE)	Neurological Disease
BChE-IN-28 (compound 6J) is a selective butyrylcholinesterase (BChE) inhibitor with an IC₅₀ of 8 nM and a K_i of 12.16 nM. BChE-IN-28 shows the lower inhibition against AChE, MAO-A and MAO-B .

HY-144324

AChE-IN-6	Cholinesterase (ChE)	Neurological Disease
AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC₅₀ = 0.20 μM; HuAChE, IC₅₀ = 37.02 nM) and anti-Aβ activity (IC₅₀ = 1.92 μM for self-induced Aβ1-42 aggregation; IC₅₀ = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC₅₀ = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC₅₀ = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils). AChE-IN-6 has the potential for the research of Alzheimer's disease .

HY-107047

BGC-201259 RS-1259	Cholinesterase (ChE) Serotonin Transporter 5-HT Receptor Calcium Channel Sodium Channel Sigma Receptor	Neurological Disease
BGC-201259 (RS-1259) is an orally active inhibitor that simultaneously targets acetylcholinesterase (AChE) (IC₅₀ = 101 nM) and serotonin transporter (SERT) (IC₅₀ = 42 nM). BGC-201259 inhibits 5-HT receptor with an IC₅₀ of 90 nM. BGC-201259 exhibits strong weak activity against the NA transporter (IC₅₀ = 7.7 μM), L-type calcium channel (IC₅₀ = 3.6 μM), σ receptor (IC₅₀ = 2 μM), and sodium channel (IC₅₀ = 5.1 μM). BGC-201259 demonstrates synergistic potential in improving cognitive and emotional symptoms by balancing the inhibition of these two targets. BGC-201259 can be used in research on Alzheimer's disease .

HY-147952

AChE-IN-20	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
AChE-IN-20 (compound M26) is a potent *AChE* inhibitor with IC₅₀ value of 397.32 nM and with K_i value of 335.76 nM. AChE-IN-20 shows inhibition potency against hCA I , hCA II and α-GLY with IC₅₀ values of 84.14, 69.24 and 52.08 nM and with K_i values of 97.86, 76.23 and 57.93 nM, respectively .

HY-156356

AChE-IN-42	Cholinesterase (ChE)	Neurological Disease
AChE-IN-42 (Compound 28) is an *AChE* inhibitor (K_i: 0.44?μM) .

HY-156372

AChE-IN-44	Cholinesterase (ChE)	Neurological Disease
AChE-IN-44 (Compound Tap4) is an *AChE* inhibitor. AChE-IN-44 can be converted into the thiazole salt AChE inhibitor Tat2 .

HY-N12027

AChE/BChE-IN-14	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-14 (compound 13) is a benzylisoquinoline alkaloid isolated from the roots of Fissistigma polyanthum. AChE/BChE-IN-14 exhibits AChE and BChE inhibitions with antioxidant activities. AChE/BChE-IN-14 can be used for Alzheimer’s disease research .

HY-155713

AChE-IN-34	Cholinesterase (ChE)	Neurological Disease
AChE-IN-34 (compound 5l) is a potent and selective *AChE* inhibitor with an IC₅₀ value of 3.98 µM with no significant inhibition against BChE. AChE-IN-34 inhibits AChE with a Ki of 0.044 μM in a mixed mode (Acetylthiocholine substrate; 0.1-1 mM) .

HY-159880

AChE/BChE-IN-24	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-24 (compound 5k) is a neuroprotective agent through cholinesterase inhibition. AChE/BChE-IN-24 inhibits *AChE* and BChE with IC₅₀ values of 16.38 μM and 10.44 μM, respectively .

HY-B0841S

Acephate-d3	Isotope-Labeled Compounds Cholinesterase (ChE)	Neurological Disease
Acephate-d₃ is the deuterium labeled Acephate. Acephate is an anticholinesterase insecticide that produces cholinotoxicity. Acephate displays weak inhibition of rat AChE but potently inhibits cockroach AChE.

HY-157087

AChE/MAO-B-IN-4	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE/MAO-B-IN-4 (compound 4a) is a selective dual *AChE* and MAO-B inhibitor. AChE/MAO-B-IN-4 shows no significant inhibition activity against BChE and h-MAO-A. AChE/MAO-B-IN-4 can be used for the Alzheimer’s disease (AD) research .

HY-145235

AChE-IN-4	Cholinesterase (ChE)	Others
AChE-IN-4 shows the acetylcholine esterase inhibition (AChEI) with an IC₅₀ value of 24.1 μM.

HY-156188

AChE-IN-41	Cholinesterase (ChE)	Others
AChE-IN-41 (Compound 2) is a compound of the Galantamine Memantine hybrid. AChE-IN-41 has the inhibition ability of cholinesterase. AChE-IN-41 shows higher plasma stability and comparable microsomal stability in vitro, while showing lower half-life and faster clearance in vivo .

HY-144790

AChE-IN-12	Amyloid-β Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC₅₀s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC₅₀ = 8.8 μM). AChE-IN-12 has remarkable inhibition of self- and Cu ²⁺-induced Aβ_1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease .

HY-19651A

Zanapezil TAK-147	Cholinesterase (ChE)	Neurological Disease
Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC₅₀=51.2 nM). Zanapezil shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K_i values of 234 and 340 nM, respectively. Zanapezil can be used for the research of early stages of Alzheimer's disease (AD) .

HY-19651B

Zanapezil fumarate TAK-147 fumarate	Cholinesterase (ChE)	Neurological Disease
Zanapezil (TAK-147) fumarate is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil fumarate shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC₅₀=51.2 nM). Zanapezil fumarate shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K_i values of 234 and 340 nM, respectively. Zanapezil fumarate can be used for the research of early stages of Alzheimer's disease (AD) .

HY-112013

Isodimethoate	Cholinesterase (ChE)	Neurological Disease
Isodimethoate is a thermal decomposition product of Dimethoate (HY-B1946). Isodimethoate is a direct anticholinesterase agent and shows an inhibition to human red blood cell acetylcholinesterase (AChE) .

HY-19651

Zanapezil free base TAK-147 free base	Cholinesterase (ChE)	Neurological Disease
Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC₅₀=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K_i values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD) .

HY-N8547A

(Rac)-Sclerone 4,5-Dihydroxytetralone; 4-Hydroxy-α-tetralone	Cholinesterase (ChE)	Neurological Disease
(Rac)-Sclerone is a natural product, that can be isolated from the green husk of Carya illinoinensis. (Rac)-Sclerone shows appreciable inhibition of *AChE, with an IC₅₀* of 192.65 ± 10.12 μg/mL .

HY-144689

BChE-IN-3	Cholinesterase (ChE)	Neurological Disease
BChE-IN-3 (compound 45a) is a potent, selective, time-dependent and pseudoirreversible BChE inhibitor, with an IC₅₀ of 56.9 nM. BChE-IN-3 also shows marginal and reversible (not time-dependent) inhibition of *AChE* .

HY-161507

hCAI/II-IN-8	Carbonic Anhydrase Cholinesterase (ChE)	Metabolic Disease
hCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC₅₀ = 21.35 ± 0.39 nM (hCA I); 7.12 ± 0.12 nM (hCA II)). hCAI/II-IN-8 inhibits *AChE* and BChE as well(IC₅₀ = 46.27 ±0.75 nM (AChE); 43.38 ± 0.83 nM (BChE)). . .

HY-N16645

Plasiaticine B	Cholinesterase (ChE)	Cancer
Plasiaticine B (Compound 2) is an indole alkaloid found in Plantago asiatica. Plasiaticine B shows no significant cytotoxicity to HL-60, A-549 and MCF-7 cells with IC₅₀ >40 μM. Plasiaticine B shows no significant inhibitory effect on *AChE, with an inhibition* rate <60% .

HY-155823

TZ4M	Cholinesterase (ChE)	Neurological Disease
TZ4M is a 2,4-thiazolidinedione (TZD)-based anti-ADV agent with neuroprotective effects. TZ4M exhibits AChE inhibition in human plasma. TZ4M improves memory and cognitive impairment in adult rats in a scopolamine (HY-N0296)-induced Alzheimer-type model .

HY-N0740R

Jatrorrhizine chloride (Standard)	Reference Standards Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine (chloride) (Standard) is the analytical standard of Jatrorrhizine (chloride). This product is intended for research and analytical applications. Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-147955

hCAI/II-IN-5	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease Metabolic Disease
hCAI/II-IN-5 (compound MZ8) is a potent hCA I and hCA II (human carbonic anhydrase isoenzymes I and II) inhibitor, with IC₅₀ values of 37.88 and 45.23 nM, respectively. hCAI/II-IN-5 also shows inhibition profile against α-Glycosidase and *AChE, with IC₅₀* values of 48.98 and 420.14 nM, respectively. hCAI/II-IN-5 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy .

HY-158978

Multitarget AD inhibitor-2	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Multitarget AD inhibitor-2 (Compound VN-19) is a multitargeting inhibitor acetylcholinesterase (AChE, IC₅₀=0.14 μM), butyrylcholinesterase (BChE, IC₅₀=11.6 μM), monoamine oxidase B (MAO B, IC₅₀=0.45 μM). Multitarget AD inhibitor-2 inhibits self-induced aggregation of amyloid beta protein Aβ1-42 (inhibition rate is 47.3% at 20 μM), and downregulates the level of ROS in SH-SY5Y (80 inhibition rate at 25 μM). Multitarget AD inhibitor-2 ameliorates the cognitive decline in Scopolamine (HY-N0296)-induced Alzheimer’s Disease zebrafish models .

HY-147954

α-Glycosidase-IN-1	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease Metabolic Disease
α-Glycosidase-IN-1 (compound MZ7) is a potent α-GLY (α-Glycosidase) inhibitor, with an IC₅₀ of 44.72 nM and a K_I of 41.74 nM. α-Glycosidase-IN-1 also shows inhibition profile against human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), and acetylcholinesterase (AChE), with IC₅₀ values of 104.87, 100.04, and 654.87 nM, respectively. α-Glycosidase-IN-1 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy .

HY-181744

AChE-IN-108	Cholinesterase (ChE)	Neurological Disease
AChE-IN-108 is a potent mixed-type acetylcholinesterase (AChE) inhibitor with an in vitro IC₅₀ of 0.17 nM. AChE-IN-108 acts on both free AChE and the enzyme-substrate complex to exert mixed-type inhibition. AChE-IN-108 can be used for the study of acetylcholinesterase inhibition in Alzheimer’s disease (AD) .

HY-181161

AChE-IN-107	Cholinesterase (ChE)	Neurological Disease
AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 0.22 μM and a K_i of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease .

HY-N10032

(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol	Cholinesterase (ChE)	Others
(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol (compound 3) is an inhibitor targeting acetylcholinesterase (AChE). At a concentration of 100 μg/mL, (3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol exhibits an in vitro inhibition rate of 12% against *AChE* .

HY-180842

MAO-B-IN-50	Monoamine Oxidase Amyloid-β Tau Protein Cholinesterase (ChE)	Neurological Disease
MAO-B-IN-50 (Compound C20) is a selective MAO-B inhibitor with an IC₅₀ value of 0.06 μM. MAO-B-IN-50 shows good inhibitory effects on the aggregation of Aβ40/42 and Tau proteins, with overall IC₅₀ values around 1 μM. MAO-B-IN-50 exhibits potent and selective *AChE* inhibition (IC₅₀ = 1.78 μM). MAO-B-IN-50 can be used in the research of Alzheimer's disease .

HY-120131

Cyanofenphos	Insecticide Cholinesterase (ChE)	Neurological Disease
Cyanofenphos is an orally active organophosphate insecticide and brain *AChE* inhibitor with neurotoxicity. Cyanofenphos induces delayed neurotoxicity such as ataxia and paralysis. Cyanofenphos also causes symptoms including somnolence, reduced feed intake and weight loss in hens. Cyanofenphos has a unique self-antagonistic effect: repeated low-dose pre-treatment not only reduces subsequent acute toxicity, but also exacerbates delayed neurotoxicity and attenuates enzyme inhibition, with the protective effect peaking at 24 h after the last pre-treatment. Cyanofenphos is commonly used in studies related to delayed neurotoxicity .

HY-180843

Aβ/tau aggregation-IN-4	Tau Protein Amyloid-β Cholinesterase (ChE) Monoamine Oxidase Reactive Oxygen Species (ROS)	Neurological Disease
Aβ/tau aggregation-IN-4 (Compound D21) is an Aβ/tau aggregation inhibitor. Aβ/tau aggregation-IN-4 promotes the degradation of Aβ40/42 (Aβ40, IC₅₀ = 2.151 μM; Aβ42, IC₅₀ = 3.622 μM). Aβ/tau aggregation-IN-4 shows selective *AChE* inhibition (IC₅₀: 5.56 μM). Aβ/tau aggregation-IN-4 inhibits MAO-A and MAO-B with IC₅₀s of 0.59 μM and 0.09 μM, respectively. Aβ/tau aggregation-IN-4 suppresses intracellular ROS levels. Aβ/tau aggregation-IN-4 can be used in the research of Alzheimer's disease .

Cat. No.	Product Name	Category	Target	Chemical Structure