Aβ/tau aggregation-IN-4
Aβ/tau aggregation-IN-4 (Compound D21) is an Aβ/tau aggregation inhibitor. Aβ/tau aggregation-IN-4 promotes the degradation of Aβ40/42 (Aβ40, IC50 = 2.151 μM; Aβ42, IC50 = 3.622 μM). Aβ/tau aggregation-IN-4 shows selective AChE inhibition (IC50: 5.56 μM). Aβ/tau aggregation-IN-4 inhibits MAO-A and MAO-B with IC50s of 0.59 μM and 0.09 μM, respectively. Aβ/tau aggregation-IN-4 suppresses intracellular ROS levels. Aβ/tau aggregation-IN-4 can be used in the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 3105860-83-8
- Formula: C17H12N2O6
- Molecular Weight:340.29
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 2.151 μM (Aβ40); 3.622 μM (Aβ42); 5.56 μM (AChE); 0.59 μM (MAO-A); 0.09 μM (MAO-B)[1]
Chemical Information
-
CAS No. 3105860-83-8
-
Molecular Weight 340.29
-
Formula C17H12N2O6
-
SMILES
O=C(N/N=C/C1=COC2=C(C=C(O)C=C2)C1=O)C3=CC=C(O)C=C3O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz