2. Neuronal Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Tau Protein Amyloid-β Cholinesterase (ChE) Monoamine Oxidase Reactive Oxygen Species (ROS)
  4. Aβ/tau aggregation-IN-4

Aβ/tau aggregation-IN-4 (Compound D21) is an Aβ/tau aggregation inhibitor. Aβ/tau aggregation-IN-4 promotes the degradation of Aβ40/42 (Aβ40, IC50 = 2.151 μM; Aβ42, IC50 = 3.622 μM). Aβ/tau aggregation-IN-4 shows selective AChE inhibition (IC50: 5.56 μM). Aβ/tau aggregation-IN-4 inhibits MAO-A and MAO-B with IC50s of 0.59 μM and 0.09 μM, respectively. Aβ/tau aggregation-IN-4 suppresses intracellular ROS levels. Aβ/tau aggregation-IN-4 can be used in the research of Alzheimer's disease.

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Aβ/tau aggregation-IN-4

Aβ/tau aggregation-IN-4 Chemical Structure

CAS No. : 3105860-83-8

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Aβ/tau aggregation-IN-4 Related Antibodies

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AChE BChE

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MAO-A MAO-B

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Description

Aβ/tau aggregation-IN-4 (Compound D21) is an Aβ/tau aggregation inhibitor. Aβ/tau aggregation-IN-4 promotes the degradation of Aβ40/42 (Aβ40, IC50 = 2.151 μM; Aβ42, IC50 = 3.622 μM). Aβ/tau aggregation-IN-4 shows selective AChE inhibition (IC50: 5.56 μM). Aβ/tau aggregation-IN-4 inhibits MAO-A and MAO-B with IC50s of 0.59 μM and 0.09 μM, respectively. Aβ/tau aggregation-IN-4 suppresses intracellular ROS levels. Aβ/tau aggregation-IN-4 can be used in the research of Alzheimer's disease[1].

IC50 & Target

IC50: 2.151 μM (Aβ40); 3.622 μM (Aβ42); 5.56 μM (AChE); 0.59 μM (MAO-A); 0.09 μM (MAO-B)[1]
Molecular Weight

340.29

Formula

C17H12N2O6
CAS No.
SMILES

O=C(N/N=C/C1=COC2=C(C=C(O)C=C2)C1=O)C3=CC=C(O)C=C3O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aβ/tau aggregation-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ/tau aggregation-IN-43105860-83-8Tau ProteinAmyloid-βCholinesterase (ChE)Monoamine OxidaseReactive Oxygen Species (ROS)β-amyloid peptideAβAbetaMAOInhibitorinhibitorinhibit

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