2. Neuronal Signaling
  3. Monoamine Oxidase Amyloid-β Tau Protein Cholinesterase (ChE)
  4. MAO-B-IN-50

MAO-B-IN-50 (Compound C20) is a selective MAO-B inhibitor with an IC50 value of 0.06 μM. MAO-B-IN-50 shows good inhibitory effects on the aggregation of Aβ40/42 and Tau proteins, with overall IC50 values around 1 μM. MAO-B-IN-50 exhibits potent and selective AChE inhibition (IC50 = 1.78 μM). MAO-B-IN-50 can be used in the research of Alzheimer's disease.

For research use only. We do not sell to patients.

MAO-B-IN-50

MAO-B-IN-50 Chemical Structure

CAS No. : 3105860-84-9

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MAO-B-IN-50 Related Antibodies

Top Publications Citing Use of Products

View All Monoamine Oxidase Isoform Specific Products:

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MAO-A MAO-B

View All Cholinesterase (ChE) Isoform Specific Products:

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AChE BChE

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Description

MAO-B-IN-50 (Compound C20) is a selective MAO-B inhibitor with an IC50 value of 0.06 μM. MAO-B-IN-50 shows good inhibitory effects on the aggregation of Aβ40/42 and Tau proteins, with overall IC50 values around 1 μM. MAO-B-IN-50 exhibits potent and selective AChE inhibition (IC50 = 1.78 μM). MAO-B-IN-50 can be used in the research of Alzheimer's disease[1].

IC50 & Target

MAO-B

0.06 μM (IC50)

MAO-A

0.98 μM (IC50)

AChE

1.78 μM (IC50)

Molecular Weight

516.50

Formula

C28H24N2O8
CAS No.
SMILES

O=C1/C(C(OC)OC2=C1C=C(O)C=C2)=C\NC3=CC=C(N/C=C4C(OC)OC5=C(C=C(O)C=C5)C\4=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-B-IN-50 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-503105860-84-9Monoamine OxidaseAmyloid-βTau ProteinCholinesterase (ChE)MAOβ-amyloid peptideAβAbetaAlzheimer's diseaseInhibitorinhibitorinhibit

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