3105860-84-9
3105860-84-9
Chemical Structure
MAO-B-IN-50
- CAS No.: 3105860-84-9
- Formula:C28H24N2O8
- Molecular Weight:516.50
InChIKey: DTADJGJVXMJLQR-VOKWCDJLSA-N
SMILES: O=C1/C(C(OC)OC2=C1C=C(O)C=C2)=C\NC3=CC=C(N/C=C4C(OC)OC5=C(C=C(O)C=C5)C\4=O)C=C3
Biological Activity: MAO-B-IN-50 (Compound C20) is a selective MAO-B inhibitor with an IC50 value of 0.06 μM. MAO-B-IN-50 shows good inhibitory effects on the aggregation of Aβ40/42 and Tau proteins, with overall IC50 values around 1 μM. MAO-B-IN-50 exhibits potent and selective AChE inhibition (IC50 = 1.78 μM). MAO-B-IN-50 can be used in the research of Alzheimer's disease[1].
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MAO-B-IN-50 | MAO-B-IN-50 (Compound C20) is a selective MAO-B inhibitor with an IC50 value of 0.06 μM. MAO-B-IN-50 shows good inhibitory effects on the aggregation of Aβ40/42 and Tau proteins, with overall IC50 values around 1 μM. MAO-B-IN-50 exhibits potent and selective AChE inhibition (IC50 = 1.78 μM). MAO-B-IN-50 can be used in the research of Alzheimer's disease. | |||||||||||||||||||||
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References
Keywords
