AChE-IN-108
AChE-IN-108 is a potent mixed-type acetylcholinesterase (AChE) inhibitor with an in vitro IC50 of 0.17 nM. AChE-IN-108 acts on both free AChE and the enzyme-substrate complex to exert mixed-type inhibition. AChE-IN-108 can be used for the study of acetylcholinesterase inhibition in Alzheimer’s disease (AD).
For research use only. We do not sell to patients.
- Formula: C25H18BrFN4O3
- Molecular Weight:521.34
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
AChE 0.17 nM (IC50) |
AChE-IN-108 (compound 32) potently inhibits acetylcholinesterase with an IC50 of 0.17 nM in an in vitro modified Ellman assay[1].
AChE-IN-108 (20-120% of its IC50) acts as a mixed-type inhibitor of AChE, interacting with both free AChE and the enzyme-substrate complex to alter substrate binding affinity and maximum catalytic velocity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 521.34
-
Formula C25H18BrFN4O3
-
SMILES
O=C1NC2=CC=C(C=C2/C1=C/C3=CC=C(C=C3)N4C=C[N+](CC5=CC(F)=CC=C5)=C4)[N+]([O-])=O.[Br-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-108 Related Classifications
HY-181744 Related Classifications
Powered by Bioz