AChE-IN-108
AChE-IN-108 is a potent mixed-type acetylcholinesterase (AChE) inhibitor with an in vitro IC50 of 0.17 nM. AChE-IN-108 acts on both free AChE and the enzyme-substrate complex to exert mixed-type inhibition. AChE-IN-108 can be used for the study of acetylcholinesterase inhibition in Alzheimer’s disease (AD).
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- Fòrmula: C25H18BrFN4O3
- Peso molecular:521.34
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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AChE 0.17 nM (IC50) |
AChE-IN-108 (compound 32) potently inhibits acetylcholinesterase with an IC50 of 0.17 nM in an in vitro modified Ellman assay[1].
AChE-IN-108 (20-120% of its IC50) acts as a mixed-type inhibitor of AChE, interacting with both free AChE and the enzyme-substrate complex to alter substrate binding affinity and maximum catalytic velocity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 521.34
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Fòrmula C25H18BrFN4O3
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SMILES
O=C1NC2=CC=C(C=C2/C1=C/C3=CC=C(C=C3)N4C=C[N+](CC5=CC(F)=CC=C5)=C4)[N+]([O-])=O.[Br-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-108 Related Classifications
HY-181744 Related Classifications
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