Coumarin 106
Based on 1 Customer Validation
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56).
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 41175-45-5
- Formula: C18H19NO2
- Molecular Weight:281.35
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Coumarin 106 is non-toxic in Caco-2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 41175-45-5
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Appearance Solid
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Molecular Weight 281.35
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Formula C18H19NO2
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Color Light green to green
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SMILES
O=C1OC2=C(C=C3C4=C2CCCN4CCC3)C5=C1CCC5
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Synonyms
Coumarin 478
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 25 mg/mL (88.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. [Content Brief]
[2]. Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58(3-4):215-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5543 mL | 17.7715 mL | 35.5429 mL | 88.8573 mL |
| 5 mM | 0.7109 mL | 3.5543 mL | 7.1086 mL | 17.7715 mL | |
| 10 mM | 0.3554 mL | 1.7771 mL | 3.5543 mL | 8.8857 mL | |
| 15 mM | 0.2370 mL | 1.1848 mL | 2.3695 mL | 5.9238 mL | |
| 20 mM | 0.1777 mL | 0.8886 mL | 1.7771 mL | 4.4429 mL | |
| 25 mM | 0.1422 mL | 0.7109 mL | 1.4217 mL | 3.5543 mL | |
| 30 mM | 0.1185 mL | 0.5924 mL | 1.1848 mL | 2.9619 mL | |
| 40 mM | 0.0889 mL | 0.4443 mL | 0.8886 mL | 2.2214 mL | |
| 50 mM | 0.0711 mL | 0.3554 mL | 0.7109 mL | 1.7771 mL | |
| 60 mM | 0.0592 mL | 0.2962 mL | 0.5924 mL | 1.4810 mL | |
| 80 mM | 0.0444 mL | 0.2221 mL | 0.4443 mL | 1.1107 mL |
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