hCAI/II-IN-8
hCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC50 = 21.35 ± 0.39 nM (hCA I); 7.12 ± 0.12 nM (hCA II)). hCAI/II-IN-8 inhibits AChE and BChE as well(IC50 = 46.27 ±0.75 nM (AChE); 43.38 ± 0.83 nM (BChE)). ..
For research use only. We do not sell to patients.
- CAS No.: 3036136-18-9
- Formula: C22H20N4O3
- Molecular Weight:388.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA I 21.35 nM (IC50) |
hCA II 7.12 nM (IC50) |
AChE 46.27 ±0.7 nM (IC50) |
BChE 43.38 ± 0. nM (IC50) |
hCAI/II-IN-8 is an efficient activity inhibitor by forming multiple hydrogen bonds and hydrophobic interactions with key residues in hCA I and hCA II. hCAI/II-IN-8 also has high stability in binding to the enzyme[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3036136-18-9
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Molecular Weight 388.42
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Formula C22H20N4O3
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SMILES
CN(C)C1=CC=C(C(OC2=CC=C(/C=N/NC(C3=CN=CC=C3)=O)C=C2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAI/II-IN-8 Related Classifications
HY-161507 Related Classifications
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