2. Others Neuronal Signaling
  3. Insecticide Cholinesterase (ChE)
  4. Cyanofenphos

Cyanofenphos is an orally active organophosphate insecticide and brain AChE inhibitor with neurotoxicity. Cyanofenphos induces delayed neurotoxicity such as ataxia and paralysis. Cyanofenphos also causes symptoms including somnolence, reduced feed intake and weight loss in hens. Cyanofenphos has a unique self-antagonistic effect: repeated low-dose pre-treatment not only reduces subsequent acute toxicity, but also exacerbates delayed neurotoxicity and attenuates enzyme inhibition, with the protective effect peaking at 24 h after the last pre-treatment. Cyanofenphos is commonly used in studies related to delayed neurotoxicity.

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Cyanofenphos

Cyanofenphos Chemical Structure

CAS No. : 13067-93-1

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Description

Cyanofenphos is an orally active organophosphate insecticide and brain AChE inhibitor with neurotoxicity. Cyanofenphos induces delayed neurotoxicity such as ataxia and paralysis. Cyanofenphos also causes symptoms including somnolence, reduced feed intake and weight loss in hens. Cyanofenphos has a unique self-antagonistic effect: repeated low-dose pre-treatment not only reduces subsequent acute toxicity, but also exacerbates delayed neurotoxicity and attenuates enzyme inhibition, with the protective effect peaking at 24 h after the last pre-treatment. Cyanofenphos is commonly used in studies related to delayed neurotoxicity[1][2].

IC50 & Target

AChE

 

In Vivo

Cyanofenphos (10-20 mg/kg; p.o.; daily; 8 days) pretreatment significantly reduces the acute toxicity of subsequent high-dose cyanofenphos in hens, increasing the LD50 from 700 to 1170 mg/kg and reducing 7-day mortality from 77% to 20% following a 1000 mg/kg challenge[1].
Cyanofenphos (80 mg/kg; oral; single dose) induces delayed neurotoxicity in hens following cyanofenphos challenge doses, with higher neurotoxicity incidence observed for 200 mg/kg compared to 100 mg/kg challenge doses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Domestic hens (2-3 months old, body weight 1.30-2.00 kg)[2]
Dosage: 80 mg/kg (pretreatment); 100 mg/kg, 200 mg/kg (challenge)
Administration: oral; single dose (pretreatment); oral; single dose (challenge, 24 hours or 8 days after pretreatment)
Result: Resulted in 0 acute deaths and 20% (2/10 hens) developing slight ataxia for 100 mg/kg challenge at 24-hour interval.
Resulted in 0 acute deaths and 10% (1/10 hens) developing slight ataxia for 100 mg/kg challenge at 8-day interval.
Resulted in 0 acute deaths and 80% (8/10 hens) developing ataxia for 200 mg/kg challenge at 24-hour interval.
Resulted in 1 acute death and 89% (8/9 surviving hens) developing neurotoxicity for 200 mg/kg challenge at 8-day interval.
Molecular Weight

303.32

Formula

C15H14NO2PS
CAS No.
SMILES

N#CC1=CC=C(OP(=S)(OCC)C=2C=CC=CC2)C=C1
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyanofenphos Related Classifications

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Keywords:

Cyanofenphos13067-93-1InsecticideCholinesterase (ChE)paralysisataxianeurotoxic deathneurotoxicantorganophosphorus insecticidedelayed neurotoxicitybrain acetylcholinesterasehensInhibitorinhibitorinhibit

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