1. Neuronal Signaling
  2. AChE
    Amyloid-β
  3. AChE/BuChE-IN-2

AChE/BuChE-IN-2 

Cat. No.: HY-146142
Handling Instructions

AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB.

For research use only. We do not sell to patients.

AChE/BuChE-IN-2 Chemical Structure

AChE/BuChE-IN-2 Chemical Structure

CAS No. : 1946008-31-6

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Description

AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1].

IC50 & Target

IC50: 0.16 μM (BuChE), 0.72 μM (AChE), 62.52 μM (Aβ aggregation)[1]

In Vivo

AChE/BuChE-IN-2 (Compound 5f) (20 μmol/kg) significantly ameliorates the cognitive performances of scopolamine-treated ICR mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

318.37

Formula

C20H18N2O2

CAS No.
SMILES

C1(C2=CC=C(OCO3)C3=C2)=NC4=CC=CC=C4C(N5CCCC5)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Product Name:
AChE/BuChE-IN-2
Cat. No.:
HY-146142
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