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Results for "

COX-1/2-IN-4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (46) Akt (1) Amyloid-β (1) Apoptosis (22) Autophagy (8) Bacterial (3) Bcl-2 Family (1) Beta-lactamase (1) Carbonic Anhydrase (1) Caspase (12) CFTR (4) Cytochrome P450 (1) Dengue Virus (1) Drug Metabolite (2) Endogenous Metabolite (2) Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (4) Environmental Pollutants (1) ERK (2) FAAH (1) Heme Oxygenase (HO) (1) Interleukin Related (4) Isotope-Labeled Compounds (9) JNK (2) Keap1-Nrf2 (2) Lactate Dehydrogenase (1) LOX-1 (1) Mitophagy (7) NF-κB (12) NO Synthase (5) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (9) Parasite (6) PGE synthase (3) Phosphodiesterase (PDE) (1) PPAR (2) Prostaglandin Receptor (2) RANKL/RANK (1) Reactive Oxygen Species (ROS) (2) Reference Standards (9) SOD (4) STAT (1) TNF Receptor (3) TRP Channel (1) VEGFR (1) Virus Protease (7)
By Research Areas:	Cancer (30) Cardiovascular Disease (13) Infection (17) Inflammation/Immunology (39) Metabolic Disease (15) Neurological Disease (13)

By Targets:

COX (46)

Akt (1)

Amyloid-β (1)

Apoptosis (22)

Autophagy (8)

Bacterial (3)

Bcl-2 Family (1)

Beta-lactamase (1)

Carbonic Anhydrase (1)

Caspase (12)

CFTR (4)

Cytochrome P450 (1)

Dengue Virus (1)

Drug Metabolite (2)

Endogenous Metabolite (2)

Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (4)

Environmental Pollutants (1)

ERK (2)

FAAH (1)

Heme Oxygenase (HO) (1)

Interleukin Related (4)

Isotope-Labeled Compounds (9)

JNK (2)

Keap1-Nrf2 (2)

Lactate Dehydrogenase (1)

LOX-1 (1)

Mitophagy (7)

NF-κB (12)

NO Synthase (5)

Nuclear Factor of activated T Cells (NFAT) (1)

p38 MAPK (9)

Parasite (6)

PGE synthase (3)

Phosphodiesterase (PDE) (1)

PPAR (2)

Prostaglandin Receptor (2)

RANKL/RANK (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (9)

SOD (4)

STAT (1)

TNF Receptor (3)

TRP Channel (1)

VEGFR (1)

Virus Protease (7)

By Research Areas:

Cancer (30)

Cardiovascular Disease (13)

Infection (17)

Inflammation/Immunology (39)

Metabolic Disease (15)

Neurological Disease (13)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: COX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14654

Aspirin 30+ Cited Publications Acetylsalicylic acid; ASA	Environmental Pollutants Autophagy NF-κB Apoptosis COX Mitophagy Virus Protease Caspase p38 MAPK	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase *COX-1* and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-B0578

Loxoprofen 1 Publications Verification	COX	Cardiovascular Disease Inflammation/Immunology Cancer
Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity ^[2] .

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor	Inflammation/Immunology Cancer
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both *COX-1* and COX-2 (COX-1: IC₅₀=0.005 μM; COX-2:IC₅₀=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer ^[2] .

HY-14654R

Aspirin (Standard) 30+ Cited Publications Acetylsalicylic acid(Standard); ASA (Standard)	Reference Standards COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Aspirin (Standard) is the analytical standard of Aspirin. This product is intended for research and analytical applications. Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase *COX-1* and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-N0481

Roburic acid 1 Publications Verification	COX TNF Receptor NO Synthase Interleukin Related NF-κB Apoptosis p38 MAPK JNK ERK Keap1-Nrf2 RANKL/RANK	Neurological Disease Inflammation/Immunology Cancer
Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a K_i of 7.066 μM against human TNF, an IC₅₀ of 9 μM against human COX-2, and an IC₅₀ of 5 μM against ovine *COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6* in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the TNF-TNF-R1 interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases ^[2] .

HY-B1153

Glafenine 4 Publications Verification GlafenIN	COX CFTR Apoptosis Endoplasmic Reticulum Oxidoreductase 1 (ERO1)	Metabolic Disease Inflammation/Immunology
Glafenine (Glafenin) is a non-selective, non-steroidal anti-inflammatory drug-based *COX-1/COX-2* inhibitor. Glafenine exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF) ^[2] .

HY-15321

Etoricoxib MK-0663; L-791456	COX	Inflammation/Immunology Cancer
Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor. Etoricoxib can cross the blood-brain barrier, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and *COX-1* in human whole blood ^[2] .

HY-B1138

Fenbufen 1 Publications Verification CL-82204	COX Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against *COX-1* and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor ^[2] .

HY-N2736

3′,4′,7-Trihydroxyflavone 1 Publications Verification	Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family	Infection Neurological Disease Inflammation/Immunology
3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC₅₀ = 1.89 μM) and *COX-1* (IC₅₀ = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H₂O₂-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice ^[2] .

HY-B0531

Triflusal	COX Phosphodiesterase (PDE) NF-κB NO Synthase Prostaglandin Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Triflusal is an orally bioavailable, blood-brain barrier-permeable dual Cyclooxygenase-1 (COX-1)/cAMP phosphodiesterase inhibitor. Triflusal inhibits platelet aggregation, NF-κB activation, iNOS activity, and prostaglandin synthesis in ischaemic tissue. Triflusal stimulates neutrophil nitric oxide production, eNOS protein expression, and cNOS activity. Triflusal alleviates cerebral ischemic injury in rats and ameliorates pathological lesions and related gene expression in transgenic Alzheimer’s disease models. Triflusal can be used for the research of thromboembolic/ischemic cardiovascular and cerebrovascular diseases, and Alzheimer’s disease ^[2] .

HY-B0578A

Loxoprofen sodium 1 Publications Verification	COX	Cardiovascular Disease Inflammation/Immunology Cancer
Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium can reduce atherosclerosis and shows antitumor activity ^[2] .

HY-N0920

Dihydrokavain 7,8-DihydrokawaIN; 7,8-DihydrokavaIN; MarINdININ	COX Cytochrome P450	Neurological Disease Inflammation/Immunology
Dihydrokavain (7,8-Dihydrokawain) is a natural kavalactone compound. Dihydrokavain inhibits *COX-1, COX-2, CYP2C9* (IC₅₀ = 130.95 μM), CYP2C19 (IC₅₀ = 10.05 μM) and CYP3A4 (IC₅₀ = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects ^[2] .

HY-N6962

α-Spinasterol	TRP Channel COX Bacterial	Infection Neurological Disease Metabolic Disease
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( TRPV1), and it's also an inhibitor of *COX-1* and COX-2, with IC₅₀ values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice ^[2] .

HY-B0641

Felbinac 4-Biphenylacetic acid	COX	Inflammation/Immunology
Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC₅₀ of 865.68 nM for *COX1* and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity ^[2] .

HY-124481

Oleocanthal	COX Reactive Oxygen Species (ROS) NO Synthase Keap1-Nrf2 Heme Oxygenase (HO) Amyloid-β Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Oleocanthal is an orally active phenolic seciridoid compound. Oleocanthal can be extracted from olive oil. Oleocanthal inhibits *COX-1* and COX-2, reduces ROS and NO, and upregulates Nrf-2 and HO-1. Oleocanthal reduces Aβ deposition. Oleocanthal exhibits anti-Leishmania activity against promastigotes and amastigotes of L. major, with IC₅₀ values of 18.7 and 87 μg/mL, respectively. Oleocanthal exhibits anticancer activity against colon, breast, liver, and melanoma cancers. Oleocanthal also exhibits anti-inflammatory and neuroprotective properties. Oleocanthal can be used in Alzheimer's disease research ^[2] .

HY-14654S1

Aspirin-d4 Acetylsalicylic acid-d₄; ASA-d₄	Isotope-Labeled Compounds COX Autophagy Mitophagy Virus Protease NF-κB Apoptosis Caspase p38 MAPK	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Aspirin-d₄ is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase *COX-1* and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-14654S

Aspirin-d3 Acetylsalicylic acid-d₃; ASA-d₃	Isotope-Labeled Compounds COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Aspirin-d₃ is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase *COX-1* and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-B1153A

Glafenine hydrochloride 4 Publications Verification GlafenIN hydrochloride	COX CFTR Apoptosis Endoplasmic Reticulum Oxidoreductase 1 (ERO1)	Metabolic Disease Inflammation/Immunology
Glafenine (Glafenin) hydrochloride is a non-selective, non-steroidal anti-inflammatory drug-based *COX-1/COX-2* inhibitor. Glafenine hydrochloride exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine hydrochloride can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine hydrochloride can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF) ^[2] .

HY-B1153R

Glafenine (Standard) GlafenIN (Standard)	COX CFTR Apoptosis Endoplasmic Reticulum Oxidoreductase 1 (ERO1) Reference Standards	Metabolic Disease Inflammation/Immunology
Glafenine (Standard) is the analytical standard of Glafenine. This product is intended for research and analytical applications. Glafenine (Glafenin) is a non-selective, non-steroidal anti-inflammatory drug-based COX-1/COX-2 inhibitor. Glafenine exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF) ^[2] .

HY-B0578B

Loxoprofen sodium dihydrate	COX	Cardiovascular Disease Inflammation/Immunology Cancer
Loxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium dihydrate can reduce atherosclerosis and shows antitumor activity ^[2] .

HY-100586

Ibuprofen L-lysine 20+ Cited Publications (±)-Ibuprofen L-lysINe	COX Apoptosis Parasite	Infection Inflammation/Immunology Cancer
Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective *COX-1* inhibitor with an IC₅₀ value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[2] .

HY-78131CS

Ibuprofen-d3 sodium 1 Publications Verification (±)-Ibuprofen-d3 sodium	Apoptosis COX Isotope-Labeled Compounds Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Ibuprofen-d₃ ((±)-Ibuprofen-d₃) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective *COX-1* inhibitor with an IC₅₀ value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[2] .

HY-78131S3

Ibuprofen-13C6 (±)-Ibuprofen-¹³C₆	Isotope-Labeled Compounds Apoptosis Parasite COX	Cancer
Ibuprofen- ¹³C₆ ((±)-Ibuprofen- ¹³C₆) is a ¹³C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective *COX-1* inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[2] .

HY-149269

COX-2-IN-30	COX Carbonic Anhydrase LOX-1	Inflammation/Immunology
COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC₅₀=49 nM for COX-2, 10.4 μM for COX-1) and 5-LOX (IC₅₀=2.4 μM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss K_i values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect .

HY-17509

Deracoxib 1 Publications Verification SC 046; SC 46; SC 59046	COX Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Deracoxib (SC 046; SC 59046), an orally active COX-2 inhibitor, is a veterinary nonsteroidal anti-inflammatory agent used exclusively in dogs. Deracoxib inhibits the COX-2 enzyme to reduce the production of prostaglandins, effectively controlling pain and inflammation after canine soft tissue surgery. Deracoxib reduces the inhibition of COX-1 and lowers the risk of gastrointestinal side effects. Deracoxib induces tumor cell cycle arrest and apoptosis, and shows anti-tumor activity in canine osteosarcoma, breast tumors and bladder transitional cell carcinomas ^[2] .

HY-123823

Nitroaspirin NCX 4016	COX Apoptosis	Cancer
Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of *COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis* in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins ^[2] .

HY-160431

8(9)-EET	PPAR NF-κB COX Drug Metabolite	Metabolic Disease
8(9)-EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. 8(9)-EET is an effective substrate for *COX-1* and COX-2. 8(9)-EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of 8(9)-EET ([(8S,9R)-EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate ^[2] .

HY-N0346

4-Methoxycinnamic acid ethyl ester Ethyl p-methoxycINnamate	COX NF-κB TNF Receptor Interleukin Related Apoptosis VEGFR Bacterial Dengue Virus Caspase	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found. 4-Methoxycinnamic acid ethyl ester exerts anti-inflammatory effects by inhibiting cyclooxygenase (COX-1 (IC₅₀ = 1.12 μM) and COX-2 (IC₅₀ = 0.83 μM)), NF-κB (IC₅₀ = 88.7 μM) and cytokine production (TNF-α (IC₅₀ = 96.84 μg/mL) and IL-1β (IC₅₀ = 166.4 μg/mL)). 4-Methoxycinnamic acid ethyl ester inhibits tumor cell proliferation, migration and cancer metabolism and induces apoptosis.4-Methoxycinnamic acid ethyl ester inhibits VEGF expression, thereby inhibiting angiogenesis. 4-Methoxycinnamic acid ethyl ester has a significant inhibitory effect on dengue virus and Mycobacterium tuberculosis. 4-Methoxycinnamic acid ethyl ester has analgesic effects in rats ^[2] .

HY-155764

*COX-1/2-IN-4*	COX	Cancer
COX-1/2-IN-4 (compound 2b) is anCOX inhibitorwith IC₅₀ values of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme , respectively. COX-1/2-IN-4showsmoderateanticanceractivity against COLO205 and B16F1 cancer cell lines with IC₅₀ values of 30.79 and 74.15 μM, respectively .

HY-15321S2

Etoricoxib-d3 MK-0663-d₃; L-791456-d₃	COX	Inflammation/Immunology
Etoricoxib-d₃ is the deuterium labeled Etoricoxib . Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood ^[2] .

HY-14654C

Aspirin calcium Acetylsalicylic acid calcium; ASA calcium	COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
Aspirin calcium is an orally active, potent and irreversible inhibitor of cyclooxygenase *COX-1* and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin calcium induces apoptosis. Aspirin calcium inhibits the activation of NF-κB. Aspirin calcium also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-14654A

Aspirin lithium Acetylsalicylic acid lithium; ASA lithium	COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
Aspirin (Acetylsalicylic Acid) lithium is an orally active, potent and irreversible inhibitor of cyclooxygenase *COX-1* and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin lithium induces apoptosis. Aspirin lithium inhibits the activation of NF-κB. Aspirin lithium also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-78131S2

Ibuprofen-d4	Isotope-Labeled Compounds COX Apoptosis Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Ibuprofen-d₄ is a deuterium labeled Ibuprofen (HY-78131). Ibuprofen is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[2] .

HY-W268542

4-Acetylaminoantipyrine	COX SOD PGE synthase	Inflammation/Immunology Cancer
4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX) . 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD ^[2]. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation .

HY-B1227S1

Carprofen-13C,d3	FAAH COX Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen- ¹³C,d₃ is the deuterium and ¹³C labeled Carprofen . Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively ^[2] .

HY-W654009

Loxoprofen-d3	Isotope-Labeled Compounds COX	Inflammation/Immunology
Loxoprofen-d₃ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity ^[2] .

HY-B0578AR

Loxoprofen sodium (Standard)	Reference Standards COX	Cardiovascular Disease Inflammation/Immunology Cancer
Loxoprofen (sodium) (Standard) is the analytical standard of Loxoprofen (sodium). This product is intended for research and analytical applications. Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium can reduce atherosclerosis and shows antitumor activity ^[2] .

HY-B0578R

Loxoprofen (Standard)	Reference Standards COX	Cardiovascular Disease Inflammation/Immunology Cancer
Loxoprofen (Standard) is the analytical standard of Loxoprofen. This product is intended for research and analytical applications. Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity ^[2] .

HY-119413R

9-Ethyladenine (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease
Loxoprofen (sodium) (Standard) is the analytical standard of Loxoprofen (sodium). This product is intended for research and analytical applications. Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium can reduce atherosclerosis and shows antitumor activity ^[2] .

HY-W707656

Aspirin-d7	Isotope-Labeled Compounds p38 MAPK Apoptosis Caspase COX Autophagy NF-κB Mitophagy Virus Protease	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Aspirin-d₇ is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-100586R

Ibuprofen L-lysine (Standard) (±)-Ibuprofen L-lysINe (Standard)	Reference Standards COX Apoptosis Parasite	Infection Inflammation/Immunology Cancer
Ibuprofen (L-lysine) (Standard) is the analytical standard of Ibuprofen (L-lysine). This product is intended for research and analytical applications. Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[2] .

HY-B1138R

Fenbufen (Standard) CL-82204 (Standard)	Reference Standards COX Caspase	Inflammation/Immunology
Fenbufen (Standard) is the analytical standard of Fenbufen. This product is intended for research and analytical applications. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against *COX-1* and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor ^[2] .

HY-B1138S

Fenbufen-d9	Isotope-Labeled Compounds COX Caspase	Inflammation/Immunology
Fenbufen-d₉ (CL-82204-d₉) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor ^[2] .

HY-B1153AR

Glafenine hydrochloride (Standard) GlafenIN hydrochloride (Standard)	COX CFTR Apoptosis Endoplasmic Reticulum Oxidoreductase 1 (ERO1) Reference Standards	Metabolic Disease Inflammation/Immunology
Glafenine (hydrochloride) (Standard) is the analytical standard of Glafenine (hydrochloride). This product is intended for research and analytical applications. Glafenine (Glafenin) hydrochloride is a non-selective, non-steroidal anti-inflammatory drug-based COX-1/COX-2 inhibitor. Glafenine hydrochloride exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine hydrochloride can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine hydrochloride can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF) ^[2] .

HY-W268542S1

4-Acetylaminoantipyrine-d3	Isotope-Labeled Compounds COX PGE synthase SOD	Cancer
4-Acetylaminoantipyrine-d₃ is the deuterium labeled 4-Acetylaminoantipyrine (HY-W268542). 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX) . 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD ^[2]. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation .

HY-W268542R

4-Acetylaminoantipyrine (Standard)	Reference Standards COX SOD PGE synthase	Inflammation/Immunology Cancer
4-Acetylaminoantipyrine (Standard) is the analytical standard of 4-Acetylaminoantipyrine. This product is intended for research and analytical applications. 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX) . 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD ^[2]. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation .

HY-179488

(±)8(9)-EET	PPAR NF-κB COX Drug Metabolite	Metabolic Disease
(±)8(9)-EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. (±)8(9)-EET is an effective substrate for *COX-1* and COX-2. (±)8(9)-EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of (±)8(9)-EET ([(8S,9R)-EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate ^[2] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both *COX-1* and COX-2 (COX-1: IC₅₀=0.005 μM; COX-2:IC₅₀=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer ^[2] .

HY-N0481

Roburic acid 1 Publications Verification	Triterpenes Structural Classification Gentiana macrophylla Pall. Classification of Application Fields Terpenoids Gentianaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	COX TNF Receptor NO Synthase Interleukin Related NF-κB Apoptosis p38 MAPK JNK ERK Keap1-Nrf2 RANKL/RANK
Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a K_i of 7.066 μM against human TNF, an IC₅₀ of 9 μM against human COX-2, and an IC₅₀ of 5 μM against ovine *COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6* in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the TNF-TNF-R1 interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases ^[2] .

HY-N2736

3′,4′,7-Trihydroxyflavone 1 Publications Verification	Flavonoids Classification of Application Fields Flavones Leguminosae Other Diseases Phenols Polyphenols Plants Vicia faba L. Disease Research Fields Source Classification	Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family
3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC₅₀ = 1.89 μM) and *COX-1* (IC₅₀ = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H₂O₂-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice ^[2] .

HY-N0920

Dihydrokavain 7,8-DihydrokawaIN; 7,8-DihydrokavaIN; MarINdININ	Structural Classification Natural Products other families Plants Source Classification	COX Cytochrome P450
Dihydrokavain (7,8-Dihydrokawain) is a natural kavalactone compound. Dihydrokavain inhibits *COX-1, COX-2, CYP2C9* (IC₅₀ = 130.95 μM), CYP2C19 (IC₅₀ = 10.05 μM) and CYP3A4 (IC₅₀ = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects ^[2] .

HY-N6962

α-Spinasterol	Structural Classification Plants Caryophyllaceae Melandrium firmum (S. et Z . ) Rohrb. Steroids	TRP Channel COX Bacterial
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( TRPV1), and it's also an inhibitor of *COX-1* and COX-2, with IC₅₀ values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice ^[2] .

HY-124481

Oleocanthal	Monophenols Canarium album (Lour.) Rauesch. Phenols Plants Burseraceae Source Classification	COX Reactive Oxygen Species (ROS) NO Synthase Keap1-Nrf2 Heme Oxygenase (HO) Amyloid-β Parasite
Oleocanthal is an orally active phenolic seciridoid compound. Oleocanthal can be extracted from olive oil. Oleocanthal inhibits *COX-1* and COX-2, reduces ROS and NO, and upregulates Nrf-2 and HO-1. Oleocanthal reduces Aβ deposition. Oleocanthal exhibits anti-Leishmania activity against promastigotes and amastigotes of L. major, with IC₅₀ values of 18.7 and 87 μg/mL, respectively. Oleocanthal exhibits anticancer activity against colon, breast, liver, and melanoma cancers. Oleocanthal also exhibits anti-inflammatory and neuroprotective properties. Oleocanthal can be used in Alzheimer's disease research ^[2] .

HY-N0346

4-Methoxycinnamic acid ethyl ester Ethyl p-methoxycINnamate	Structural Classification Kaempferia galanga L. Iridoids Terpenoids Plants Source Classification Zingiberaceae	COX NF-κB TNF Receptor Interleukin Related Apoptosis VEGFR Bacterial Dengue Virus Caspase
4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found. 4-Methoxycinnamic acid ethyl ester exerts anti-inflammatory effects by inhibiting cyclooxygenase (COX-1 (IC₅₀ = 1.12 μM) and COX-2 (IC₅₀ = 0.83 μM)), NF-κB (IC₅₀ = 88.7 μM) and cytokine production (TNF-α (IC₅₀ = 96.84 μg/mL) and IL-1β (IC₅₀ = 166.4 μg/mL)). 4-Methoxycinnamic acid ethyl ester inhibits tumor cell proliferation, migration and cancer metabolism and induces apoptosis.4-Methoxycinnamic acid ethyl ester inhibits VEGF expression, thereby inhibiting angiogenesis. 4-Methoxycinnamic acid ethyl ester has a significant inhibitory effect on dengue virus and Mycobacterium tuberculosis. 4-Methoxycinnamic acid ethyl ester has analgesic effects in rats ^[2] .

HY-119413R

9-Ethyladenine (Standard)	Natural Products Microorganisms Source Classification	Reference Standards Endogenous Metabolite
Loxoprofen (sodium) (Standard) is the analytical standard of Loxoprofen (sodium). This product is intended for research and analytical applications. Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium can reduce atherosclerosis and shows antitumor activity ^[2] .

Cat. No.	Product Name	Chemical Structure

HY-14654S1

Aspirin-d4

Aspirin-d₄ is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-14654S

Aspirin-d3

Aspirin-d₃ is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-78131CS

Ibuprofen-d3 sodium

1 Publications Verification

Ibuprofen-d₃ ((±)-Ibuprofen-d₃) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[2] .

HY-78131S3

Ibuprofen-13C6

Ibuprofen- ¹³C₆ ((±)-Ibuprofen- ¹³C₆) is a ¹³C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[2] .

HY-15321S2

Etoricoxib-d3
Etoricoxib-d₃ is the deuterium labeled Etoricoxib . Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood ^[2] .

HY-78131S2

Ibuprofen-d4

Ibuprofen-d₄ is a deuterium labeled Ibuprofen (HY-78131). Ibuprofen is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[2] .

HY-B1227S1

Carprofen-13C,d3
Carprofen- ¹³C,d₃ is the deuterium and ¹³C labeled Carprofen . Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively ^[2] .

HY-W654009

Loxoprofen-d3
Loxoprofen-d₃ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity ^[2] .

HY-W707656

Aspirin-d7

Aspirin-d₇ is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[2] .

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d₉) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor ^[2] .

HY-W268542S1

4-Acetylaminoantipyrine-d3

4-Acetylaminoantipyrine-d₃ is the deuterium labeled 4-Acetylaminoantipyrine (HY-W268542). 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX) . 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD ^[2]. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation .

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