Aspirin calcium
Based on 39 publication(s) in Google Scholar
Aspirin calcium is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin calcium induces apoptosis. Aspirin calcium inhibits the activation of NF-κB. Aspirin calcium also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
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- CAS. Nr.: 69-46-5
- Formel: C9H7O4.1/2Ca
- Molecular Weight:200.20
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Publications Citing Use of MedChemExpress (MCE) Aspirin calcium
More- Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
- Cancer Res. 2018 Oct 1;78(19):5586-5599. [Abstract]
- Nat Commun. 2024 Sep 10;15(1):7914. [Abstract]
- Genes Dis. 2026 Jun 15.
- Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]
- Cell Commun Signal. 2025 Jan 15;23(1):29. [Abstract]
- J Pharm Anal. 2026 Mar 11.
- Microsyst Nanoeng. 2026 Jan 1;12(1):7. [Abstract]
- Adv Healthc Mater. 2025 Aug 11:e00602. [Abstract]
- NPJ Sci Food. 2022 Dec 5;6(1):55. [Abstract]
- Food Res Int. 2026 Feb 6.
- Mol Med. 2024 Aug 16;30(1):126. [Abstract]
- ACS Appl Mater Interfaces. 2025 Apr 2;17(13):19286-19303. [Abstract]
- Cell Prolif. 2023 Apr;56(4):e13380. [Abstract]
- Front Immunol. 2021 Dec 1:12:734546. [Abstract]
- Neurosci Bull. 2025 May 6. [Abstract]
- Ecotoxicol Environ Saf. 2025 Jul 15:300:118466. [Abstract]
- Pharmaceuticals (Basel). 2025 Nov 1;18(11):1657. [Abstract]
- Int Immunopharmacol. 2026 Aug 15:183:116873. [Abstract]
- Int J Mol Sci. 2022 Aug 14;23(16):9118. [Abstract]
- Front Pharmacol. 2022 Jan 10;12:792263. [Abstract]
- Front Cell Dev Biol. 2023 Sep 8:11:1266198. [Abstract]
- ACS Omega. 2020 Aug 4;5(32):19995-20003. [Abstract]
- Spectrochim Acta A Mol Biomol Spectrosc. 2026 Jan 15:345:126769. [Abstract]
- J Cell Mol Med. 2025 Jul;29(13):e70696. [Abstract]
- Brain Res Bull. 2026 Jan:234:111689. [Abstract]
- Mol Nutr Food Res. 2024 Sep;68(17):e2400307. [Abstract]
- Clin Chim Acta. 2025 Dec 31:120816. [Abstract]
- Funct Integr Genomics. 2026 Jun 23;26(1):155. [Abstract]
- Neurotoxicology. 2022 Mar:89:20-30. [Abstract]
- Food Chem Toxicol. 2023 Aug:178:113919. [Abstract]
- J Appl Toxicol. 2024 Oct;44(10):1528-1539. [Abstract]
- PLoS One. 2023 May 19;18(5):e0285216. [Abstract]
- Biomed Rep. 2026 Jun 24;25(2):99. [Abstract]
- STAR Protoc. 2021 Aug 27;2(3):100787. [Abstract]
- bioRxiv. 2025 Jul 12:2025.07.08.663754. [Abstract]
- bioRxiv. 2025 January 21.
- Oxid Med Cell Longev. 2022 Feb 9;2022:4295208. [Abstract]
- Eur Rev Med Pharmacol Sci. 2020 Jul;24(13):7381-7390. [Abstract]
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Beschreibung
In Vitro
Aspirin calcium inhibits COX-1 and COX-2 in human articular chondrocytes, with IC50 values of 3.57 μM and 29.3 μM, respectively[2].
Aspirin calcium acetylates serine-530 of COX-1, thereby blocking thromboxane A synthesis in platelets and reducing platelet aggregation[3].
Aspirin calcium inhibits COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer[3].
Aspirin calcium inhibits NF-κB-dependent transcription from the lgκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells[4].
Aspirin calcium induces apoptosis by the activation of caspases, the activation of p38 MAP kinase, release of mitochondrial cytochrome c, and activation of the ceramide pathway[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Aspirin (5-150 mg/kg, PO, once) calcium shows significant antipyretic activity in adult yeast-fevered male rats[7].
Aspirin calcium can be used to induce gastrointestinal ulcer models[8].
Administration: 500 mg/kg • oral • single dose
Resulted in a decrease in the mucosal thickness.
Induced ulcer without COX-1 reaction.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino Charles River rats (200-250 g, 8 animals/group, fever was induced by 20 mL/kg of a 20% aqueous suspension of brewer’s yeast which was injected SC in the back below the nape of the neck)[7]
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Dosage:5, 25, 50, 100 and 150 mg/kg
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Administration:PO, once
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Result:Produced a statistically significant decrease of 0.23°C at 15 min post-drug at the dose of 150 mg/kg. Antipyretic effect gradually increased in magnitude until a peak effect of 1.96 °C was reached at 120 min post-drug. The ED50 of aspirin was found to be 10.3 mg/kg with confidence limits of 1.8-23.0 mg/kg. The antipyretic response to aspirin is dependent on the dose of the compound administered.
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Animal Model:Albino male mice [8]
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Dosage:500 mg/kg, single dose
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Administration:oral
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Result:Caused erosion of the surface epithelial cells.
Resulted in a decrease in the mucosal thickness.
Induced ulcer without COX-1 reaction.
Chemical Information
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CAS. Nr. 69-46-5
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Molecular Weight 200.20
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Formel C9H7O4.1/2Ca
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SMILES
O=C(C1=C(OC(C)=O)C=CC=C1)[O-].[0.5].[Ca+2]
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Synonyms
Acetylsalicylic acid calcium; ASA calcium
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (39)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage. [Abstract]2024 Feb 14;32(2):191-208.e9. PMID: 38237593
Aspirin calcium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
C57BL/6J mice were treated with aspirin [2 mg/mL (11.1 mM) in drinking water] for 2 weeks and feces collected for 16S sequencing (n=6/group). PLS-DA of 16S sequencing (n=6/group) (Asp 0d vs Asp 14d).
Aspirin calcium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
C57BL/6J mice were treated with aspirin [2 mg/mL (11.1 mM) in drinking water] for 2 weeks and feces collected for 16S sequencing (n=6/group). The three indexes of α-diversity of mice fecal microbiota (Asp 0d vs Asp 14d).
Aspirin calcium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
C57BL/6J mice were subjected to oral aspirin treatment for 2 weeks by adding aspirin into the drinking water at a concentration of 2 mg/mL (11.1mM), with or without antibiotics (neomycin). Representative images of H&E staining of intestine and injury scores for each group are shown. Random 10 positions of distal jejunum were picked and the average scores calculated for all mice (n=10 replicates/group). Scale bar: 200 μm.
Aspirin calcium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
C57BL/6J mice were subjected to oral aspirin treatment for 2 weeks by adding aspirin into the drinking water at a concentration of 2 mg/mL (11.1mM), with or without antibiotics (neomycin). Ki67 staining of distal jejunum of mice. The quantitative comparison of Ki67 staining of intestinal crypts (red dotted lines, n = 5/group) were shown.
Aspirin calcium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
Transmission Electron Microscopy (TEM) of intestinal tissues from mice subjected to oral aspirin treatment for 2 weeks by adding aspirin into the drinking water at a concentration of 2 mg/mL (11.1mM), with or without antibiotics (neomycin).
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Cancer Res
A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis. [Abstract]2018 Oct 1;78(19):5586-5599. PMID: 30012671 -
Nat Commun
A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner. [Abstract]2024 Sep 10;15(1):7914. PMID: 39256385 -
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Cell Death Dis
Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy. [Abstract]2018 Aug 28;9(9):847. PMID: 30154452
Aspirin calcium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]
HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM Vitamin E, and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.
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Cell Commun Signal
PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer. [Abstract]2025 Jan 15;23(1):29. PMID: 39815258 -
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Microsyst Nanoeng
2026 Jan 1;12(1):7. PMID: 41476049 -
Adv Healthc Mater
Novel Drug-Testing Platform for Vascular Injury-induced Intimal Hyperplasia Using a Microphysiological System. [Abstract]2025 Aug 11:e00602. PMID: 40787716 -
NPJ Sci Food
Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model. [Abstract]2022 Dec 5;6(1):55. PMID: 36470888 -
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Mol Med
Aspirin attenuates the detrimental effects of TNF-α on BMMSC stemness by modulating the YAP-SMAD7 axis. [Abstract]2024 Aug 16;30(1):126. PMID: 39152406 -
ACS Appl Mater Interfaces
Facile Nanocomposite Hydrogel Scaffold with Sustained Drug Release and Osteo-Immunomodulatory Effects to Enhance Bone Regeneration. [Abstract]2025 Apr 2;17(13):19286-19303. PMID: 40116446 -
Cell Prolif
2023 Apr;56(4):e13380. PMID: 36495056 -
Front Immunol
Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling. [Abstract]2021 Dec 1:12:734546. PMID: 34925318 -
Neurosci Bull
A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response. [Abstract]2025 May 6. PMID: 40329138 -
Ecotoxicol Environ Saf
Polystyrene microplastics induces senescence of osteocytes by activating the cyclooxygenase-2 signaling pathway. [Abstract]2025 Jul 15:300:118466. PMID: 40466333 -
Pharmaceuticals (Basel)
Photothermal Therapy Combined with Chemotherapy and Anti-Inflammation Therapy Weakens the Immunosuppression of Cervical Cancer. [Abstract]2025 Nov 1;18(11):1657. PMID: 41304902 -
Int Immunopharmacol
Oxyphenbutazone suppresses non-canonical inflammasome activation and protects against LPS-induced sepsis. [Abstract]2026 Aug 15:183:116873. PMID: 42150290 -
Int J Mol Sci
Rescue of Mitochondrial SIRT3 Ameliorates Ischemia-like Injury in Human Endothelial Cells. [Abstract]2022 Aug 14;23(16):9118. PMID: 36012382 -
Front Pharmacol
Hsp47 Inhibitor Col003 Attenuates Collagen-Induced Platelet Activation and Cerebral Ischemic-Reperfusion Injury in Rats. [Abstract]2022 Jan 10;12:792263. PMID: 35082674 -
Front Cell Dev Biol
Chlorpromazine affects autophagy in association with altered Rag GTPase-mTORC1-TFEB signaling. [Abstract]2023 Sep 8:11:1266198. PMID: 37745295 -
ACS Omega
Purification and Characterization of Novel Collagen Peptides against Platelet Aggregation and Thrombosis from Salmo salar. [Abstract]2020 Aug 4;5(32):19995-20003. PMID: 32832753 -
Spectrochim Acta A Mol Biomol Spectrosc
Harmonizing drug analysis and sustainability: Spectroscopic quantification of antiplatelet-anticoagulant regimens. [Abstract]2026 Jan 15:345:126769. PMID: 40779897 -
J Cell Mol Med
2025 Jul;29(13):e70696. PMID: 40611443 -
Brain Res Bull
Cycloastragenol protected hippocampal CA1 neurons by regulating redox homeostasis and alleviated cognitive impairment following cerebral ischemia-reperfusion. [Abstract]2026 Jan:234:111689. PMID: 41407128 -
Mol Nutr Food Res
Aqueous Extract of Wolfberry Alleviates Aging-Related Skeletal Muscle Dysfunction by Modulating PRRs Signaling Pathways and Enhancing DNA Repair. [Abstract]2024 Sep;68(17):e2400307. PMID: 39091066 -
Clin Chim Acta
Simultaneous quantification of acetylsalicylic acid, clopidogrel, ticagrelor and their major metabolites in human plasma by liquid chromatography-tandem mass spectrometry. [Abstract]2025 Dec 31:120816. PMID: 41482259 -
Funct Integr Genomics
Integration of transcriptome and mendelian randomization elucidates the protective role of aspirin in pulmonary tuberculosis development. [Abstract]2026 Jun 23;26(1):155. PMID: 42332333 -
Neurotoxicology
Aspirin ameliorates the cognition impairment in mice following benzo[a]pyrene treatment via down-regulating BDNF IV methylation. [Abstract]2022 Mar:89:20-30. PMID: 34979192 -
Food Chem Toxicol
Aspirin ameliorates the neurotoxicity of benzo[a]pyrene in mice and HT22 cells: Possible role of miRNA-mRNA network. [Abstract]2023 Aug:178:113919. PMID: 37364758 -
J Appl Toxicol
Differential impacts of nonsteroidal anti-inflammatory drugs on lifespan and healthspan in aged Caenorhabditis elegans. [Abstract]2024 Oct;44(10):1528-1539. PMID: 38840409 -
PLoS One
Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles. [Abstract]2023 May 19;18(5):e0285216. PMID: 37205684 -
Biomed Rep
Toxicity evaluation and anti-ischemic stroke activity of selected natural extracts in zebrafish. [Abstract]2026 Jun 24;25(2):99. PMID: 42388451 -
STAR Protoc
Protocol for targeting the magnocellular neuroendocrine cell ensemble via retrograde tracing from the posterior pituitary. [Abstract]2021 Aug 27;2(3):100787. PMID: 34485946 -
bioRxiv
2025 Jul 12:2025.07.08.663754. PMID: 40672312 -
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Oxid Med Cell Longev
Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis. [Abstract]2022 Feb 9;2022:4295208. PMID: 35186185 -
Eur Rev Med Pharmacol Sci
Autophagy assuages myocardial infarction through Nrf2 signaling activation-mediated reactive oxygen species clear. [Abstract]2020 Jul;24(13):7381-7390. PMID: 32706077
Protokoll
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Apoptosis
Apoptosis, also called programmed cell death, is generally characterized by distinct morphological characteristics.
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TUNEL staining for apoptotic DNA fragmentation
TUNEL staining detects DNA strand breaks by using terminal deoxynucleotidyl transferase to add labeled nucleotides to exposed 3′-OH DNA termini, generating either microscopic staining in fixed cells or tissue sections, or fluorescence/cytometric signal in cell suspensions. TUNEL positivity reflects DNA fragmentation but should not be interpreted alone as definitive apoptosis, because TUNEL can also label necrotic, autolytic, mechanically damaged, or DNA-repair-associated DNA breaks.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Annexin V plus membrane-impermeant dye apoptosis staining
Annexin V-based apoptosis assays rely on the detection of phosphatidylserine (PS) externalization from the inner leaflet of the plasma membrane to the outer leaflet, an early biochemical hallmark of apoptosis. Fluorescently labeled Annexin V binds PS in a calcium-dependent manner, enabling identification of early apoptotic cells by flow cytometry or fluorescence microscopy. When combined with a membrane-impermeant DNA-binding dye (e. g. , propidium iodide), this approach allows discrimination between viable (Annexin V−/dye−), early apoptotic (Annexin V+/dye−), and late apoptotic or necrotic (Annexin V+/dye+) cell populations by assessing membrane integrity and PS exposure.
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Apoptosis Solutions
Apoptosis is a regulated, generally non-lytic cell-death pathway that removes unwanted, damaged, infected, or abnormal cells through coordinated morphological changes, caspase activation, DNA fragmentation, and membrane remodeling. The intrinsic apoptosis pathway is controlled mainly by mitochondrial outer membrane permeabilization, BCL-2 family proteins, cytochrome c release, apoptosome formation, caspase-9 activation, and downstream executioner caspase-3/7 activation. The extrinsic apoptosis pathway is initiated by death receptors such as Fas, TNFR, and TRAIL receptors, which recruit adaptor proteins and activate caspase-8 before engaging executioner caspases or mitochondrial amplification through BID cleavage. Apoptosis is linked to many phenotypes, including cancer cell killing, tissue homeostasis, immune regulation, neurodegeneration, infection response, and treatment-induced cytotoxicity; unresolved questions include how apoptosis interacts with necroptosis, pyroptosis, ferroptos
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Reinheit & Dokumentation
Verweise
[1]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [Content Brief]
[2]. Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73. [Content Brief]
[3]. Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12. [Content Brief]
[4]. Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9. [Content Brief]
[5]. Burch JW, et al. Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest. 1978 Feb;61(2):314-9. [Content Brief]
[6]. Elwood PC, et al. Aspirin, salicylates, and cancer. Lancet. 2009 Apr 11;373(9671):1301-9. [Content Brief]
[7]. Loux JJ, DePalma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxicol Appl Pharmacol. 1972 Aug;22(4):672-5. [Content Brief]
[8]. Yomna I Mahmoud, et al. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. Biomed Pharmacother. 2019. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Aspirin calcium Related Classifications
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