Aspirin lithium
Based on 35 publication(s) in Google Scholar
Aspirin (Acetylsalicylic Acid) lithium is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin lithium induces apoptosis. Aspirin lithium inhibits the activation of NF-κB. Aspirin lithium also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
For research use only. We do not sell to patients.
- CAS No.: 552-98-7
- Formula: C9H7LiO4
- Molecular Weight:186.09
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Aspirin lithium
More- Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
- Cancer Res. 2018 Oct 1;78(19):5586-5599. [Abstract]
- Nat Commun. 2024 Sep 10;15(1):7914. [Abstract]
- Microsyst Nanoeng. 2026 Jan 1;12(1):7. [Abstract]
- Adv Healthc Mater. 2025 Aug 11:e00602. [Abstract]
- Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]
- J Pharm Anal. 2026 Mar 11.
- Cell Commun Signal. 2025 Jan 15;23(1):29. [Abstract]
- ACS Appl Mater Interfaces. 2025 Apr 2;17(13):19286-19303. [Abstract]
- Food Res Int. 2026 Feb 6.
- NPJ Sci Food. 2022 Dec 5;6(1):55. [Abstract]
- Mol Med. 2024 Aug 16;30(1):126. [Abstract]
- Ecotoxicol Environ Saf. 2025 Jun 3:300:118466. [Abstract]
- Front Immunol. 2021 Dec 1:12:734546. [Abstract]
- Neurosci Bull. 2025 May 6. [Abstract]
- Cell Prolif. 2023 Apr;56(4):e13380. [Abstract]
- Int J Mol Sci. 2022 Aug 14;23(16):9118. [Abstract]
- Front Pharmacol. 2022 Jan 10;12:792263. [Abstract]
- Spectrochim Acta A Mol Biomol Spectrosc. 2026 Jan 15:345:126769. [Abstract]
- Front Cell Dev Biol. 2023 Sep 8:11:1266198. [Abstract]
- ACS Omega. 2020 Aug 4;5(32):19995-20003. [Abstract]
- J Cell Mol Med. 2025 Jul;29(13):e70696. [Abstract]
- Mol Nutr Food Res. 2024 Aug 1:e2400307. [Abstract]
- Neurotoxicology. 2022 Mar:89:20-30. [Abstract]
- Brain Res Bull. 2025 Dec 15:234:111689. [Abstract]
- Food Chem Toxicol. 2023 Aug:178:113919. [Abstract]
- Clin Chim Acta. 2025 Dec 31:120816. [Abstract]
- J Appl Toxicol. 2024 Oct;44(10):1528-1539. [Abstract]
- PLoS One. 2023 May 19;18(5):e0285216. [Abstract]
- Biomed Rep. 2026 Jun 24;25(2):99. [Abstract]
- STAR Protoc. 2021 Aug 27;2(3):100787. [Abstract]
- bioRxiv. 2025 Jul 12:2025.07.08.663754. [Abstract]
- bioRxiv. 2025 January 21.
- Oxid Med Cell Longev. 2022 Feb 9;2022:4295208. [Abstract]
- Eur Rev Med Pharmacol Sci. 2020 Jul;24(13):7381-7390. [Abstract]
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Biological Activity
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COX-1 |
COX-2 |
Aspirin lithium inhibits COX-1 and COX-2 in human articular chondrocytes, with IC50 values of 3.57 μM and 29.3 μM, respectively[2].
Aspirin lithium acetylates serine-530 of COX-1, thereby blocking thromboxane A synthesis in platelets and reducing platelet aggregation[3].
Aspirin lithium inhibits COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer[3].
Aspirin lithium inhibits NF-κB-dependent transcription from the lgκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells[4].
Aspirin lithium induces apoptosis by the activation of caspases, the activation of p38 MAP kinase, release of mitochondrial cytochrome c, and activation of the ceramide pathway[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino Charles River rats (200-250 g, 8 animals/group, fever was induced by 20 mL/kg of a 20% aqueous suspension of brewer’s yeast which was injected SC in the back below the nape of the neck)[7]
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Dosage:5, 25, 50, 100 and 150 mg/kg
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Administration:PO, once
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Result:Produced a statistically significant decrease of 0.23°C at 15 min post-drug at the dose of 150 mg/kg. Antipyretic effect gradually increased in magnitude until a peak effect of 1.96 °C was reached at 120 min post-drug. The ED50 of aspirin was found to be 10.3 mg/kg with confidence limits of 1.8-23.0 mg/kg. The antipyretic response to aspirin is dependent on the dose of the compound administered.
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Animal Model:Albino male mice [8]
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Dosage:500 mg/kg, single dose
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Administration:oral
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Result:Caused erosion of the surface epithelial cells.
Resulted in a decrease in the mucosal thickness.
Induced ulcer without COX-1 reaction.
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Aspirin lithium (5-150 mg/kg, PO, once) shows significant antipyretic activity in adult yeast-fevered male rats[7].
Aspirin can be used to induce gastrointestinal ulcer models[8].
Administration: 500 mg/kg • oral • single dose
Resulted in a decrease in the mucosal thickness.
Induced ulcer without COX-1 reaction.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 552-98-7
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Molecular Weight 186.09
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Formula C9H7LiO4
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SMILES
O=C(O[Li])C1=CC=CC=C1OC(C)=O
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Synonyms
Acetylsalicylic acid lithium; ASA lithium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (35)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage. [Abstract]2024 Feb 14;32(2):191-208.e9. PMID: 38237593
Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
C57BL/6J mice were treated with aspirin [2 mg/mL (11.1 mM) in drinking water] for 2 weeks and feces collected for 16S sequencing (n=6/group). PLS-DA of 16S sequencing (n=6/group) (Asp 0d vs Asp 14d).
Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
C57BL/6J mice were treated with aspirin [2 mg/mL (11.1 mM) in drinking water] for 2 weeks and feces collected for 16S sequencing (n=6/group). The three indexes of α-diversity of mice fecal microbiota (Asp 0d vs Asp 14d).
Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
C57BL/6J mice were subjected to oral aspirin treatment for 2 weeks by adding aspirin into the drinking water at a concentration of 2 mg/mL (11.1mM), with or without antibiotics (neomycin). Representative images of H&E staining of intestine and injury scores for each group are shown. Random 10 positions of distal jejunum were picked and the average scores calculated for all mice (n=10 replicates/group). Scale bar: 200 μm.
Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
C57BL/6J mice were subjected to oral aspirin treatment for 2 weeks by adding aspirin into the drinking water at a concentration of 2 mg/mL (11.1mM), with or without antibiotics (neomycin). Ki67 staining of distal jejunum of mice. The quantitative comparison of Ki67 staining of intestinal crypts (red dotted lines, n = 5/group) were shown.
Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
Transmission Electron Microscopy (TEM) of intestinal tissues from mice subjected to oral aspirin treatment for 2 weeks by adding aspirin into the drinking water at a concentration of 2 mg/mL (11.1mM), with or without antibiotics (neomycin).
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Cancer Res
A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis. [Abstract]2018 Oct 1;78(19):5586-5599. PMID: 30012671 -
Nat Commun
A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner. [Abstract]2024 Sep 10;15(1):7914. PMID: 39256385 -
Microsyst Nanoeng
2026 Jan 1;12(1):7. PMID: 41476049 -
Adv Healthc Mater
Novel Drug-Testing Platform for Vascular Injury-induced Intimal Hyperplasia Using a Microphysiological System. [Abstract]2025 Aug 11:e00602. PMID: 40787716 -
Cell Death Dis
Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy. [Abstract]2018 Aug 28;9(9):847. PMID: 30154452
Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]
HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM Vitamin E, and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.
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Cell Commun Signal
PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer. [Abstract]2025 Jan 15;23(1):29. PMID: 39815258 -
ACS Appl Mater Interfaces
Facile Nanocomposite Hydrogel Scaffold with Sustained Drug Release and Osteo-Immunomodulatory Effects to Enhance Bone Regeneration. [Abstract]2025 Apr 2;17(13):19286-19303. PMID: 40116446 -
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NPJ Sci Food
Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model. [Abstract]2022 Dec 5;6(1):55. PMID: 36470888 -
Mol Med
Aspirin attenuates the detrimental effects of TNF-α on BMMSC stemness by modulating the YAP-SMAD7 axis. [Abstract]2024 Aug 16;30(1):126. PMID: 39152406 -
Ecotoxicol Environ Saf
Polystyrene microplastics induces senescence of osteocytes by activating the cyclooxygenase-2 signaling pathway. [Abstract]2025 Jun 3:300:118466. PMID: 40466333 -
Front Immunol
Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling. [Abstract]2021 Dec 1:12:734546. PMID: 34925318 -
Neurosci Bull
A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response. [Abstract]2025 May 6. PMID: 40329138 -
Cell Prolif
2023 Apr;56(4):e13380. PMID: 36495056 -
Int J Mol Sci
Rescue of Mitochondrial SIRT3 Ameliorates Ischemia-like Injury in Human Endothelial Cells. [Abstract]2022 Aug 14;23(16):9118. PMID: 36012382 -
Front Pharmacol
Hsp47 Inhibitor Col003 Attenuates Collagen-Induced Platelet Activation and Cerebral Ischemic-Reperfusion Injury in Rats. [Abstract]2022 Jan 10;12:792263. PMID: 35082674 -
Spectrochim Acta A Mol Biomol Spectrosc
Harmonizing drug analysis and sustainability: Spectroscopic quantification of antiplatelet-anticoagulant regimens. [Abstract]2026 Jan 15:345:126769. PMID: 40779897 -
Front Cell Dev Biol
Chlorpromazine affects autophagy in association with altered Rag GTPase-mTORC1-TFEB signaling. [Abstract]2023 Sep 8:11:1266198. PMID: 37745295 -
ACS Omega
Purification and Characterization of Novel Collagen Peptides against Platelet Aggregation and Thrombosis from Salmo salar. [Abstract]2020 Aug 4;5(32):19995-20003. PMID: 32832753 -
J Cell Mol Med
2025 Jul;29(13):e70696. PMID: 40611443 -
Mol Nutr Food Res
Aqueous Extract of Wolfberry Alleviates Aging-Related Skeletal Muscle Dysfunction by Modulating PRRs Signaling Pathways and Enhancing DNA Repair. [Abstract]2024 Aug 1:e2400307. PMID: 39091066 -
Neurotoxicology
Aspirin ameliorates the cognition impairment in mice following benzo[a]pyrene treatment via down-regulating BDNF IV methylation. [Abstract]2022 Mar:89:20-30. PMID: 34979192 -
Brain Res Bull
Cycloastragenol protected hippocampal CA1 neurons by regulating redox homeostasis and alleviated cognitive impairment following cerebral ischemia-reperfusion. [Abstract]2025 Dec 15:234:111689. PMID: 41407128 -
Food Chem Toxicol
Aspirin ameliorates the neurotoxicity of benzo[a]pyrene in mice and HT22 cells: Possible role of miRNA-mRNA network. [Abstract]2023 Aug:178:113919. PMID: 37364758 -
Clin Chim Acta
Simultaneous quantification of acetylsalicylic acid, clopidogrel, ticagrelor and their major metabolites in human plasma by liquid chromatography-tandem mass spectrometry. [Abstract]2025 Dec 31:120816. PMID: 41482259 -
J Appl Toxicol
Differential impacts of nonsteroidal anti-inflammatory drugs on lifespan and healthspan in aged Caenorhabditis elegans. [Abstract]2024 Oct;44(10):1528-1539. PMID: 38840409 -
PLoS One
Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles. [Abstract]2023 May 19;18(5):e0285216. PMID: 37205684 -
Biomed Rep
Toxicity evaluation and anti-ischemic stroke activity of selected natural extracts in zebrafish. [Abstract]2026 Jun 24;25(2):99. PMID: 42388451 -
STAR Protoc
Protocol for targeting the magnocellular neuroendocrine cell ensemble via retrograde tracing from the posterior pituitary. [Abstract]2021 Aug 27;2(3):100787. PMID: 34485946 -
bioRxiv
2025 Jul 12:2025.07.08.663754. PMID: 40672312 -
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Oxid Med Cell Longev
Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis. [Abstract]2022 Feb 9;2022:4295208. PMID: 35186185 -
Eur Rev Med Pharmacol Sci
Autophagy assuages myocardial infarction through Nrf2 signaling activation-mediated reactive oxygen species clear. [Abstract]2020 Jul;24(13):7381-7390. PMID: 32706077
Purity & Documentation
References
[1]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [Content Brief]
[2]. Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73. [Content Brief]
[3]. Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12. [Content Brief]
[4]. Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9. [Content Brief]
[5]. Burch JW, et al. Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest. 1978 Feb;61(2):314-9. [Content Brief]
[6]. Elwood PC, et al. Aspirin, salicylates, and cancer. Lancet. 2009 Apr 11;373(9671):1301-9. [Content Brief]
[7]. Loux JJ, DePalma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxicol Appl Pharmacol. 1972 Aug;22(4):672-5. [Content Brief]
[8]. Yomna I Mahmoud, et al. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. Biomed Pharmacother. 2019. [Content Brief]
[9]. Yomna I Mahmoud, et al. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. Biomed Pharmacother. 2019. [Content Brief]
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