1. Immunology/Inflammation
    Apoptosis
  2. COX
    Apoptosis
  3. Nitroaspirin

Nitroaspirin (Synonyms: NCX 4016)

Cat. No.: HY-123823
Handling Instructions

Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins.

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Nitroaspirin Chemical Structure

Nitroaspirin Chemical Structure

CAS No. : 175033-36-0

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Description

Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4].

IC50 & Target[3]

COX-1

 

Molecular Weight

331.28

Formula

C₁₆H₁₃NO₇

CAS No.

175033-36-0

SMILES

O=C(OC1=CC=CC(CO[N+]([O-])=O)=C1)C2=CC=CC=C2OC(C)=O

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Keywords:

NitroaspirinNCX 4016NCX4016NCX-4016COXApoptosisCyclooxygenaseInhibitorinhibitorinhibit

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Nitroaspirin
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