COX-1/2-IN-4
COX-1/2-IN-4 (compound 2b) is anCOX inhibitorwith IC50 values of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme , respectively. COX-1/2-IN-4showsmoderateanticanceractivity against COLO205 and B16F1 cancer cell lines with IC50 values of 30.79 and 74.15 μM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2967296-91-7
- Formula: C22H24N2O2S
- Molecular Weight:380.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50= 0.239 μM (COX-1 enzyme); IC50= 0.191 μM (COX-2 enzyme)[1]
Chemical Information
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CAS No. 2967296-91-7
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Molecular Weight 380.50
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Formula C22H24N2O2S
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SMILES
CC(C)(C)C(C=C1)=CC=C1NC(C(S2)=C(N=C2C3=CC=CC(OC)=C3)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-1/2-IN-4 Related Classifications
HY-155764 Related Classifications
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