Ibuprofen-d3 sodium
Based on 1 publication(s) in Google Scholar
Ibuprofen-d3 ((±)-Ibuprofen-d3) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 1219805-09-0
- Formula: C13H14D3NaO2
- Molecular Weight:231.28
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ibuprofen-d3 sodium
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219805-09-0
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Unlabeled Cas 31121-93-4
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Appearance Solid
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Molecular Weight 231.28
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Formula C13H14D3NaO2
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Color White to off-white
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SMILES
O=C(O[Na])C(C([2H])([2H])[2H])C1=CC=C(CC(C)C)C=C1
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Synonyms
(±)-Ibuprofen-d3 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
Ethanol : ≥ 50 mg/mL (216.19 mM)
DMSO : ≥ 50 mg/mL (216.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMF : ≥ 30 mg/mL (129.71 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. [Content Brief]
[2]. Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36(5):3237-43. [Content Brief]
[3]. Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6(1):98. [Content Brief]
[4]. M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan;141(1):186-92. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / Ethanol / DMSO | 1 mM | 4.3238 mL | 21.6188 mL | 43.2376 mL | 108.0941 mL |
| 5 mM | 0.8648 mL | 4.3238 mL | 8.6475 mL | 21.6188 mL | |
| 10 mM | 0.4324 mL | 2.1619 mL | 4.3238 mL | 10.8094 mL | |
| 15 mM | 0.2883 mL | 1.4413 mL | 2.8825 mL | 7.2063 mL | |
| 20 mM | 0.2162 mL | 1.0809 mL | 2.1619 mL | 5.4047 mL | |
| 25 mM | 0.1730 mL | 0.8648 mL | 1.7295 mL | 4.3238 mL | |
| 30 mM | 0.1441 mL | 0.7206 mL | 1.4413 mL | 3.6031 mL | |
| 40 mM | 0.1081 mL | 0.5405 mL | 1.0809 mL | 2.7024 mL | |
| 50 mM | 0.0865 mL | 0.4324 mL | 0.8648 mL | 2.1619 mL | |
| 60 mM | 0.0721 mL | 0.3603 mL | 0.7206 mL | 1.8016 mL | |
| 80 mM | 0.0540 mL | 0.2702 mL | 0.5405 mL | 1.3512 mL | |
| 100 mM | 0.0432 mL | 0.2162 mL | 0.4324 mL | 1.0809 mL |
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