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Results for "

Diabetic+complication

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Aldose Reductase (20) Amylases (1) Antibiotic (1) Apoptosis (4) Biochemical Assay Reagents (2) c-Myc (2) Cytochrome P450 (1) Dipeptidyl Peptidase (4) Drug Metabolite (2) Endogenous Metabolite (2) Fatty Acid Synthase (FASN) (1) Glycosidase (1) GSK-3 (2) HIV (2) Keap1-Nrf2 (2) Mitochondrial Metabolism (2) NF-κB (1) p38 MAPK (1) PI3K (1) PKC (1) Reactive Oxygen Species (ROS) (3) Reference Standards (3) SARS-CoV (2) SOD (1) Thrombin (1) Toll-like Receptor (TLR) (1) β-catenin (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (3) Endocrinology (2) Infection (2) Inflammation/Immunology (8) Metabolic Disease (36) Neurological Disease (5)

By Targets:

Akt (3)

Aldose Reductase (20)

Amylases (1)

Antibiotic (1)

Apoptosis (4)

Biochemical Assay Reagents (2)

c-Myc (2)

Cytochrome P450 (1)

Dipeptidyl Peptidase (4)

Drug Metabolite (2)

Endogenous Metabolite (2)

Fatty Acid Synthase (FASN) (1)

Glycosidase (1)

GSK-3 (2)

HIV (2)

Keap1-Nrf2 (2)

Mitochondrial Metabolism (2)

NF-κB (1)

p38 MAPK (1)

PI3K (1)

PKC (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (3)

SARS-CoV (2)

SOD (1)

Thrombin (1)

Toll-like Receptor (TLR) (1)

β-catenin (2)

By Research Areas:

Cancer (7)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (2)

Inflammation/Immunology (8)

Metabolic Disease (36)

Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0680

Thiamine hydrochloride 1 Publications Verification Thiamine chloride hydrochloride; Vitamin B1 hydrochloride	Endogenous Metabolite Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis .

HY-P2813

Hirudin 3 Publications Verification	Thrombin Apoptosis	Cardiovascular Disease Cancer
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

HY-17374

Benfotiamine 1 Publications Verification S-Benzoylthiamine O-monophosphate	SARS-CoV HIV	Infection Metabolic Disease Inflammation/Immunology
Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19 .

HY-14892A

Gemigliptin tartrate LC15-0444 tartrate	Dipeptidyl Peptidase	Metabolic Disease
Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. Gemigliptin tartrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-19687

Zopolrestat 1 Publications Verification CP73850	Aldose Reductase	Metabolic Disease
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC₅₀ of 3.1 nM. Zopolrestat is used for the research of diabetic complications .

HY-B1069

Molsidomine 1 Publications Verification SIN-10; Morsydomine	Drug Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease
Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications .

HY-50289

Sorbinil 2 Publications Verification	Aldose Reductase	Metabolic Disease
Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.

HY-105416

Calphostin C 2 Publications Verification UCN-1028C	Antibiotic PKC Apoptosis	Metabolic Disease Cancer
Calphostin C is a highly selective PKC inhibitor (IC₅₀=0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications .

HY-N0309

Soyasaponin Ba 1 Publications Verification	Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc	Metabolic Disease
Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .

HY-13633

Exisulind 2 Publications Verification	Aldose Reductase	Metabolic Disease Cancer
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac . Exisulind inhibits aldose reductase with an IC₅₀ of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications .

HY-125863C

Glucose-6-phosphate dehydrogenase, Bacillus sp. G6PD, Bacillus sp.	Endogenous Metabolite	Others
Glucose-6-phosphate dehydrogenase, Bacillus sp. catalyzes the conversion of glucose-6-phosphate into 6-phosphogluconolactone, and produces reduced nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate in this process. Glucose-6-phosphate dehydrogenase, Bacillus sp. can be used in research about diabetic complications .

HY-14892

Gemigliptin LC15-0444	Dipeptidyl Peptidase	Metabolic Disease Cancer
Gemigliptin (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin exhibits potent anti-glycation properties. Gemigliptin can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-16433

Risarestat CT 112	Aldose Reductase	Metabolic Disease Inflammation/Immunology
Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications.

HY-E70398

Sorbitol dehydrogenase L-Iditol dehydrogenase; Polyol dehydrogenase; SDH	Biochemical Assay Reagents	Metabolic Disease
Sorbitol dehydrogenase (L-Iditol dehydrogenase) is an oxidoreductasea and catalyses the conversion of sorbitol to fructose with NAD ⁺ as the coenzyme. Sorbitol dehydrogenase catalyses pH-dependent redox reactions between NAD ⁺/NADH and sorbitol/fructose. Sorbitol dehydrogenase is implicated in diabetic complications and is a biomarker of drug-induced liver injury. Sorbitol dehydrogenase can be used for the research of diabetes and liver injury .

HY-W001094

2-Bromo-4-fluoroanisole	Biochemical Assay Reagents	Neurological Disease Metabolic Disease
2-Bromo-4-fluoroanisole is an important intermediate in organic synthesis. 2-Bromo-4-fluoroanisole can be used in the research of diabetic complications (including blindness) .

HY-N8126

Emodin 6-O-β-D-glucoside Glucoemodin	Others	Metabolic Disease Inflammation/Immunology
Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis .

HY-14892C

Gemigliptin hydrochloride LC15-0444 hydrochloride	Dipeptidyl Peptidase	Metabolic Disease Cancer
Gemigliptin hydrochloride is the hydrochloride salt of Gemigliptin (HY-14892). Gemigliptin hydrochloride is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin hydrochloride exhibits potent anti-glycation properties. Gemigliptin hydrochloride can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-178363

α-Amylase-IN-13	Amylases	Metabolic Disease Endocrinology
α-Amylase-IN-13 is an orally active, selective, brain-penetrant α-amylase inhibitor (IC₅₀ = 0.71 μM). α-Amylase-IN-13 inhibits α-amylase through a mixed type of inhibition mechanism. α-Amylase-IN-13 leads to a significant reduction in blood glucose level in diabetic rats. α-Amylase-IN-13 causes significant histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 can be used for the study of diabetic complications .

HY-N12313

Corybulbine	Aldose Reductase	Metabolic Disease
Corybulbine, an alkaloid that can be isolated from the methanolic extract of Corydalis ternata, is an aldose reductase (ALR2) inhibitor. Corybulbine can be used for diabetic complications research .

HY-175331

ALR2-IN-7	Aldose Reductase	Metabolic Disease Cancer
ALR2-IN-7 (Compound 5a) is a highly potent and selective aldose reductase (ALR2/AKR1B1) inhibitor (K_i=8.71 nM). ALR2-IN-7 is promising for research of diabetic complications (e.g., retinopathy, nephropathy) and cancers .

HY-N6883

6-Methoxytricin	Aldose Reductase	Metabolic Disease
6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi. 6-Methoxytricin (Compound 6) is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities with IC₅₀ values of 30.29 μM and 134.88 μM, respectively. 6-Methoxytricin (Compound 6) has potential as an anti-diabetic complications agent .

HY-14892B

Gemigliptin tartrate hydrate LC15-0444 tartrate hydrate	Dipeptidyl Peptidase	Metabolic Disease
Gemigliptin (LC15-0444 ) tartrate hydrate is a selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate hydrate exhibits potent anti-glycation properties. Gemigliptin tartrate hydrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-17374R

Benfotiamine (Standard) S-Benzoylthiamine O-monophosphate (Standard)	Reference Standards HIV SARS-CoV	Infection Metabolic Disease Inflammation/Immunology
Benfotiamine (Standard) is the analytical standard of Benfotiamine. This product is intended for research and analytical applications. Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19 .

HY-175862

ALR2-IN-9	Aldose Reductase Reactive Oxygen Species (ROS) PI3K Akt SOD p38 MAPK Keap1-Nrf2	Metabolic Disease
ALR2-IN-9 is a potent ALR2 inhibitor (IC₅₀ = 21.8 nM) with excellent antioxidant activity (EC₅₀ for DPPH radical scavenging = 2.8 μM). ALR2-IN-9 interacts directly with Reactive Oxygen Species (ROS)/Reactive Nitrogen Species (RNS) and interrupts the free radical chain reactions, and as an endogenous enzymatic antioxidant regulator, which regulates enzyme functions of CAT and SOD. ALR2-IN-9 regulates PI3K/Akt/Nrf2 pathway to attenuate hyperglycemia-mediated mitochondrial superoxide overproduction in vitro, and ameliorates CuSO₄- and H₂O₂-induced oxidative stress in vivo. ALR2-IN-9 prolongs lifespan of C. elegans via the regulation of stress response genes such as PMK-1. ALR2-IN-9 is a promising anti-aging drug candidate. ALR2-IN-9 can be used for diabetic complication research .

HY-115940

Aldose reductase-IN-2	Aldose Reductase	Metabolic Disease
Aldose reductase-IN-2 (Compound 5f) is a potent inhibitor of aldose reductase (AR). Aldose reductase-IN-2 has antioxidation capacity. Aldose reductase-IN-2 is a promising anti-diabetic complications agent .

HY-151947

ALR2-IN-3	Aldose Reductase	Metabolic Disease
ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC₅₀s of 22 nM and 116 nM for rat ALR2 and ALR1, respectively. ALR2-IN-2 can be used for the research of diabetic complications .

HY-151946

ALR2-IN-2	Aldose Reductase	Metabolic Disease
ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC₅₀s of 27 nM and 228 nM for rat ALR2 and ALR1, respectively. ALR2-IN-2 can be used for the research of diabetic complications .

HY-50289R

Sorbinil (Standard)	Aldose Reductase	Metabolic Disease
Sorbinil (Standard) is the analytical standard of Sorbinil. This product is intended for research and analytical applications. Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway .

HY-W715538

Rhetsinine	Aldose Reductase	Metabolic Disease
Rhetsinine is an aldose reductase inhibitor isolated from Evodia rutaecarpa, exhibiting an IC₅₀ value of 24.1 μM. At a concentration of 100 μM, rhetsinine significantly inhibits sorbitol accumulation by 79.3%. This compound shows potential for research in diabetic complications, including diabetic neuropathy and retinopathy .

HY-150630

ALR2-IN-1	Aldose Reductase	Metabolic Disease
ALR2-IN-1 is a potent and selective ALR2 inhibitor (IC₅₀=1.42 μM). ALR2-IN-1 shows antioxidant and antiglycative properties. ALR2-IN-1 can be used in diabetic complication research .

HY-146225

α-Amylase/α-Glucosidase-IN-2	Glycosidase	Metabolic Disease
α-Amylase/α-Glucosidase-IN-2 (compound 5) is a potent α-amylase and α-glucosidase dual inhibitor with IC₅₀ values of 13.02, 13.09 µM for α-amylase and α-glucosidase, respectively. α-Amylase/α-Glucosidase-IN-2 has the potential for the research of diabetic complications .

HY-B1069R

Molsidomine (Standard) SIN-10 (Standard); Morsydomine (Standard)	Reference Standards Drug Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease
Molsidomine (Standard) (SIN-10 (Standard)) is the analytical standard of Molsidomine (HY-B1069). This product is intended for research and analytical applications. Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications.

HY-N0309R

Soyasaponin Ba (Standard)	Reference Standards Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc	Metabolic Disease
Soyasaponin Ba (Standard) is the analytical standard of Soyasaponin Ba (HY-N0309). Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .

HY-183923

SX 3202	Aldose Reductase	Metabolic Disease Inflammation/Immunology
SX 3202 is an aldose reductase inhibitor. SX 3202 can be used for the research of diabetic complications .

HY-W283860

ALR2-IN-10	Aldose Reductase	Metabolic Disease
ALR2-IN-10 (Compound 23) is a weak Aldose Reductase 2 inhibitor with inhibition rate of 6% at 27 μM. ALR2-IN-10 can be used for the research of diabetic complication .

HY-W151897

Cemtirestat CMTI	Aldose Reductase	Metabolic Disease
Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase (ALR2). Cemtirestat potently inhibits rat ocular lens ALR2 with an IC₅₀ of 0.116 μM, and exhibits a 302-fold selectivity for rat kidney ALR1. Cemtirestat is applicable to the research of advanced diabetic complications .

HY-183855

WF-2421	Aldose Reductase	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
WF-2421 is an aldose reductase inhibitor with an IC₅₀ of 0.03 μM against rabbit-derived aldose reductase. WF-2421 acts as a non-competitive inhibitor of aldose reductase using dl-glyceraldehyde as the substrate. WF-2421 can be used in the research of diabetic complications (cataract, neuropathy, retinopathy, nephropathy) .

HY-N17737

Floramanoside F	Fatty Acid Synthase (FASN) Cytochrome P450	Metabolic Disease Inflammation/Immunology
Floramanoside F is a type of flavonol glycoside compound. Floramanoside F has a moderate free radical scavenging effect, with a SC₅₀ value of 25.1 μM. Floramanoside F has a relatively weak inhibitory activity on aldose reductase, with a IC₅₀ value greater than 100 μM. Floramanoside F has strong binding affinity with key target enzymes of type 1 diabetic nephropathy (T1DN) (Fasn, Cyp2e1, Cyp4a32), and can inhibit lipid accumulation and oxidative stress, thereby alleviating renal inflammation and fibrosis. Floramanoside F can be used to study type 1 diabetic nephropathy and diabetic complications .

2-Bromo-4-fluoroanisole	Biochemical Assay Reagents
2-Bromo-4-fluoroanisole is an important intermediate in organic synthesis. 2-Bromo-4-fluoroanisole can be used in the research of diabetic complications (including blindness) .

Cat. No.	Product Name	Target	Research Area

HY-P2813

Hirudin 3 Publications Verification	Thrombin Apoptosis	Cardiovascular Disease Cancer
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

Thiamine hydrochloride 1 Publications Verification Thiamine chloride hydrochloride; Vitamin B1 hydrochloride	Structural Classification Natural Products Human Gut Microbiota Metabolites Endogenous metabolite	Endogenous Metabolite Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB
Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis .

Hirudin 3 Publications Verification	Cardiovascular Disease Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification Cancer	Thrombin Apoptosis
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

Soyasaponin Ba 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc
Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .

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