Soyasaponin Ba
Based on 1 publication(s) in Google Scholar
Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.47%
- CAS 番号: 114590-20-4
- 分子式: C48H78O19
- 分子量:959.12
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Soyasaponin Ba
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生物活性
製品説明
体外実験
Soyasaponin Ba (0.78-25 μM; 0-600 s) directly binds to purified AKT1 protein with a Kd of 4.19 μM[1].
Soyasaponin Ba (4-32 μM; 24 h) dose-dependently alleviates FFA-induced intracellular ROS accumulation, and improves FFA-induced mitochondrial dysfunction in HepG2 cells[1].
Soyasaponin Ba (4-32 μM; 24 h) dose-dependently alleviates FFA-induced apoptosis in HepG2 cells[1].
Soyasaponin Ba (16-32 μM; 24 h) activates the Akt/GSK3β/β-catenin signaling pathway in FFA-induced HepG2 cells[1].
Soyasaponin Ba (8-32 μM; 24 h) dose-dependently alleviates FFA-induced lipid accumulation in THLE-2 cells[1].
Soyasaponin Ba (16-32 μM; 24 h) dose-dependently alleviates FFA-induced ROS accumulation, mitochondrial dysfunction, and apoptosis in THLE-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:4; 8; 16; 32 μM
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Incubation Time:24 h
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Result:Reduced FFA-induced apoptosis in a concentration-dependent manner, as shown by decreased green fluorescence intensity (cleaved caspase-3 activity) in single-cell imaging, normalized relative fluorescent units (RFU) in bulk culture, and reduced Annexin V-mCherry staining.
Significantly decreased caspase-3 activity at 16 and 32 μM, with effects comparable to 20 μM atorvastatin.
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Cell Line:HepG2 cells
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Concentration:16; 32 μM
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Incubation Time:24 h
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Result:Restored phosphorylated Akt and phosphorylated GSK3β levels reduced by FFA treatment at 32 μM.
Increased intracellular β-catenin and c-Myc levels reduced by FFA treatment in a concentration-dependent manner at 16 and 32 μM.
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Cell Line:HepG2 cells
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Concentration:4; 8; 16; 32 μM
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Incubation Time:24 h
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Result:Dose-dependently alleviates FFA-induced lipid accumulation in HepG2 cells.
Showed significant effects at all tested concentrations.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type N2 elegans[1]
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Dosage:16; 32; 64; 128 μM
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Administration:incorporated into nematode growth medium; every 48 hours; 3-4 total doses; from L4 stage
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Result:Dose-dependently reduced high-glucose induced lipid accumulation.
At 128 μM, reduced Nile Red fluorescence intensity significantly compared to the high-glucose untreated group.
Dose-dependently reduced high-glucose induced ROS accumulation.
化学情報
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CAS 番号 114590-20-4
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性状 Solid
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分子量 959.12
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分子式 C48H78O19
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Color White to off-white
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SMILES
O[C@H]([C@H]1O[C@@]2([H])[C@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)[C@H](O)[C@@H](C(O)=O)O[C@@]1([H])O[C@@H]4[C@@](CO)(C)[C@]5([H])CC[C@@]6(C)[C@]7(C)CC[C@@]8(C)[C@H](O)CC(C)(C)C[C@@]8([H])C7=CC[C@]6([H])[C@@]5(C)CC4
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別名
大豆サポニンBa
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Phytopathology
Untargeted metabolomic analysis reveals a potential role of saponins in the partial resistance of pea (Pisum sativum) against a root rot pathogen, Aphanomyces euteiches. [Abstract]2024 Dec;114(12):2502-2514. PMID: 39186063
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (260.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Luo J, et al. Soyasaponin Ba Alleviates Lipid Accumulation via Mitochondrial Remodeling: Multiomics Insights. J Agric Food Chem. 2025;73(33):21199-21221. [Content Brief]
[2]. Balestri F, et al. Soyasaponins from Zolfino bean as aldose reductase differential inhibitors. J Enzyme Inhib Med Chem. 2019;34(1):350-360. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0426 mL | 5.2131 mL | 10.4262 mL | 26.0656 mL |
| 5 mM | 0.2085 mL | 1.0426 mL | 2.0852 mL | 5.2131 mL | |
| 10 mM | 0.1043 mL | 0.5213 mL | 1.0426 mL | 2.6066 mL | |
| 15 mM | 0.0695 mL | 0.3475 mL | 0.6951 mL | 1.7377 mL | |
| 20 mM | 0.0521 mL | 0.2607 mL | 0.5213 mL | 1.3033 mL | |
| 25 mM | 0.0417 mL | 0.2085 mL | 0.4170 mL | 1.0426 mL | |
| 30 mM | 0.0348 mL | 0.1738 mL | 0.3475 mL | 0.8689 mL | |
| 40 mM | 0.0261 mL | 0.1303 mL | 0.2607 mL | 0.6516 mL | |
| 50 mM | 0.0209 mL | 0.1043 mL | 0.2085 mL | 0.5213 mL | |
| 60 mM | 0.0174 mL | 0.0869 mL | 0.1738 mL | 0.4344 mL | |
| 80 mM | 0.0130 mL | 0.0652 mL | 0.1303 mL | 0.3258 mL | |
| 100 mM | 0.0104 mL | 0.0521 mL | 0.1043 mL | 0.2607 mL |
Soyasaponin Ba 関連分類
HY-N0309 関連分類
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Keywords
- Soyasaponin Ba
- 114590-20-4
- Aldose Reductase
- Akt
- GSK-3
- β-catenin
- Reactive Oxygen Species (ROS)
- Mitochondrial Metabolism
- Apoptosis
- c-Myc
- Akt/GSK3β/β-catenin signaling pathway
- lipid accumulation
- wild-type N2 C. elegans
- HepG2 cells
- AKT1
- hAKR1B1
- apoptosis
- THLE-2 cells
- mitochondrial function
- reactive oxygen species
- Inhibitor
- inhibitor
- inhibit