Cat. No.: HY-N0309

Soyasaponin Ba

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications.

For research use only. We do not sell to patients.

Purity: 99.47%
CAS No.: 114590-20-4
Formula: C₄₈H₇₈O₁₉
Molecular Weight:959.12

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Soyasaponin Ba Chemical Structure

CAS No.: 114590-20-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Akt Isoforms :

All GSK-3 Isoforms :

In Vitro

Soyasaponin Ba (0.78-25 μM; 0-600 s) directly binds to purified AKT1 protein with a K_d of 4.19 μM^[1].
Soyasaponin Ba (4-32 μM; 24 h) dose-dependently alleviates FFA-induced intracellular ROS accumulation, and improves FFA-induced mitochondrial dysfunction in HepG2 cells^[1].
Soyasaponin Ba (4-32 μM; 24 h) dose-dependently alleviates FFA-induced apoptosis in HepG2 cells^[1].
Soyasaponin Ba (16-32 μM; 24 h) activates the Akt/GSK3β/β-catenin signaling pathway in FFA-induced HepG2 cells^[1].
Soyasaponin Ba (8-32 μM; 24 h) dose-dependently alleviates FFA-induced lipid accumulation in THLE-2 cells^[1].
Soyasaponin Ba (16-32 μM; 24 h) dose-dependently alleviates FFA-induced ROS accumulation, mitochondrial dysfunction, and apoptosis in THLE-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

4; 8; 16; 32 μM
Incubation Time:

24 h
Result:

Reduced FFA-induced apoptosis in a concentration-dependent manner, as shown by decreased green fluorescence intensity (cleaved caspase-3 activity) in single-cell imaging, normalized relative fluorescent units (RFU) in bulk culture, and reduced Annexin V-mCherry staining.
Significantly decreased caspase-3 activity at 16 and 32 μM, with effects comparable to 20 μM atorvastatin.

Western Blot Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

16; 32 μM
Incubation Time:

24 h
Result:

Restored phosphorylated Akt and phosphorylated GSK3β levels reduced by FFA treatment at 32 μM.
Increased intracellular β-catenin and c-Myc levels reduced by FFA treatment in a concentration-dependent manner at 16 and 32 μM.

Immunofluorescence^[1]

Cell Line:

HepG2 cells
Concentration:

4; 8; 16; 32 μM
Incubation Time:

24 h
Result:

Dose-dependently alleviates FFA-induced lipid accumulation in HepG2 cells.
Showed significant effects at all tested concentrations.

In Vivo

Soyasaponin Ba (16-128 μM; incorporated into nematode growth medium; every 48 hours; 3-4 total doses; from L4 stage) dose-dependently alleviates high-glucose induced lipid accumulation and oxidative stress in wild-type N2 C. elegans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

wild-type N2 elegans^[1]
Dosage:

16; 32; 64; 128 μM
Administration:

incorporated into nematode growth medium; every 48 hours; 3-4 total doses; from L4 stage
Result:

Dose-dependently reduced high-glucose induced lipid accumulation.
At 128 μM, reduced Nile Red fluorescence intensity significantly compared to the high-glucose untreated group.
Dose-dependently reduced high-glucose induced ROS accumulation.

Chemical Information

CAS No. 114590-20-4
Appearance Solid
Molecular Weight 959.12
Formula C₄₈H₇₈O₁₉
Color White to off-white
SMILES

O[C@H]([C@H]1O[C@@]2([H])[C@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)[C@H](O)[C@@H](C(O)=O)O[C@@]1([H])O[C@@H]4[C@@](CO)(C)[C@]5([H])CC[C@@]6(C)[C@]7(C)CC[C@@]8(C)[C@H](O)CC(C)(C)C[C@@]8([H])C7=CC[C@]6([H])[C@@]5(C)CC4
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Phytopathology

Untargeted metabolomic analysis reveals a potential role of saponins in the partial resistance of pea (Pisum sativum) against a root rot pathogen, Aphanomyces euteiches. [Abstract]

2024 Dec;114(12):2502-2514. PMID: 39186063

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (260.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0426 mL

5.2131 mL

10.4262 mL

5 mM

0.2085 mL

1.0426 mL

2.0852 mL

10 mM

0.1043 mL

0.5213 mL

1.0426 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Luo J, et al. Soyasaponin Ba Alleviates Lipid Accumulation via Mitochondrial Remodeling: Multiomics Insights. J Agric Food Chem. 2025;73(33):21199-21221. [Content Brief]

[2]. Balestri F, et al. Soyasaponins from Zolfino bean as aldose reductase differential inhibitors. J Enzyme Inhib Med Chem. 2019;34(1):350-360. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0426 mL	5.2131 mL	10.4262 mL	26.0656 mL
	5 mM	0.2085 mL	1.0426 mL	2.0852 mL	5.2131 mL
	10 mM	0.1043 mL	0.5213 mL	1.0426 mL	2.6066 mL
	15 mM	0.0695 mL	0.3475 mL	0.6951 mL	1.7377 mL
	20 mM	0.0521 mL	0.2607 mL	0.5213 mL	1.3033 mL
	25 mM	0.0417 mL	0.2085 mL	0.4170 mL	1.0426 mL
	30 mM	0.0348 mL	0.1738 mL	0.3475 mL	0.8689 mL
	40 mM	0.0261 mL	0.1303 mL	0.2607 mL	0.6516 mL
	50 mM	0.0209 mL	0.1043 mL	0.2085 mL	0.5213 mL
	60 mM	0.0174 mL	0.0869 mL	0.1738 mL	0.4344 mL
	80 mM	0.0130 mL	0.0652 mL	0.1303 mL	0.3258 mL
	100 mM	0.0104 mL	0.0521 mL	0.1043 mL	0.2607 mL

Soyasaponin Ba

1 Cited Publications

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Soyasaponin Ba

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

PI3K/Akt/mTOR Compound Library

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Publications Citing Use of MedChemExpress (MCE) Soyasaponin Ba

All Akt Isoforms

All GSK-3 Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Soyasaponin Ba Related Classifications

HY-N0309 Related Classifications